Cloning and Analysis of the Planosporicin Lantibiotic Biosynthetic Gene Cluster of Planomonospora alba

The increasing prevalence of antibiotic resistance in bacterial pathogens has renewed focus on natural products with antimicrobial properties. Lantibiotics are ribosomally synthesized peptide antibiotics that are posttranslationally modified to introduce (methyl)lanthionine bridges. Actinomycetes ar...

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Veröffentlicht in:	Journal of Bacteriology 2013-05, Vol.195 (10), p.2309-2321
Hauptverfasser:	Sherwood, Emma J, Hesketh, Andrew R, Bibb, Mervyn J
Format:	Artikel
Sprache:	eng
Schlagworte:	ABC transporters Actinomycetales - metabolism anti-infective properties antibiotic resistance Antibiotics Bacterial Proteins - genetics Bacterial Proteins - metabolism bacteriocins Bacteriocins - biosynthesis Bacteriocins - metabolism Bacteriology bioinformatics Biosynthesis cell walls Cloning Drug resistance Enzymes gene deletion Genes genome mining Gram-positive bacteria innate immunity Molecular Structure Multigene Family - genetics Multigene Family - physiology Nonomuraea operon pathogens peptide antibiotics Planomonospora alba Reverse Transcriptase Polymerase Chain Reaction Streptomyces coelicolor transcription (genetics)
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