Biochemical and hematologic effects of polyvinylpyrrolidone-wrapped fullerene C60 after oral administration
The fullerene C60 is used in consumer products such as cosmetics owing to its antioxidative effects and is being developed for nanomedical applications. However, knowledge regarding the safety of fullerene C60, especially after oral administration, is sparse. Here, we examined the safety of fulleren...
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| Veröffentlicht in: | Pharmazie 2013-01, Vol.68 (1), p.54-57 |
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| creator | Yamashita Yoshioka Pan Taira Ogura Nagano Aoyama Nagano Abe Kamada Tsunoda, S.-I. Aoshima Nabeshi Yoshikawa Tsutsumi |
| description | The fullerene C60 is used in consumer products such as cosmetics owing to its antioxidative effects and is being developed for nanomedical applications. However, knowledge regarding the safety of fullerene C60, especially after oral administration, is sparse. Here,
we examined the safety of fullerene C60 in mice after 7 d of exposure to orally administered polyvinylpyrrolidone (PVP)-wrapped fullerene C60 (PVP-fullerene C60). Mice treated with PVP-fullerene C60 showed few changes in the plasma levels of various
markers of kidney and liver injury and experienced no significant hematologic effects. Furthermore, the histology of the colon of PVP-fullerene C60 -treated mice was indistinguishable from that of control mice. These results suggest that PVP-fullerene C60 lacks toxicity
after high-dose oral administration and indicate that PVP-fullerene C60 can be considered safe for oral medication. These data provide basic information that likely will facilitate the production of safe and effective forms of fullerene C60. |
| doi_str_mv | 10.1691/ph.2013.2708 |
| format | Article |
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we examined the safety of fullerene C60 in mice after 7 d of exposure to orally administered polyvinylpyrrolidone (PVP)-wrapped fullerene C60 (PVP-fullerene C60). Mice treated with PVP-fullerene C60 showed few changes in the plasma levels of various
markers of kidney and liver injury and experienced no significant hematologic effects. Furthermore, the histology of the colon of PVP-fullerene C60 -treated mice was indistinguishable from that of control mice. These results suggest that PVP-fullerene C60 lacks toxicity
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we examined the safety of fullerene C60 in mice after 7 d of exposure to orally administered polyvinylpyrrolidone (PVP)-wrapped fullerene C60 (PVP-fullerene C60). Mice treated with PVP-fullerene C60 showed few changes in the plasma levels of various
markers of kidney and liver injury and experienced no significant hematologic effects. Furthermore, the histology of the colon of PVP-fullerene C60 -treated mice was indistinguishable from that of control mice. These results suggest that PVP-fullerene C60 lacks toxicity
after high-dose oral administration and indicate that PVP-fullerene C60 can be considered safe for oral medication. These data provide basic information that likely will facilitate the production of safe and effective forms of fullerene C60.</description><subject>Acute Kidney Injury - chemically induced</subject><subject>Acute Kidney Injury - pathology</subject><subject>Administration, Oral</subject><subject>Animals</subject><subject>Blood Cell Count</subject><subject>Chemical and Drug Induced Liver Injury - pathology</subject><subject>Colitis - chemically induced</subject><subject>Colitis - pathology</subject><subject>Female</subject><subject>Fullerenes - administration & dosage</subject><subject>Fullerenes - pharmacology</subject><subject>Light</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Povidone</subject><subject>Scattering, Radiation</subject><subject>Tissue Fixation</subject><issn>0031-7144</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kb1z1DAQxVXAJCGho2ZU0vjQ18lyCUf4mMmQBmrN2pLuFGTJSPIxl78-NjlKttlXvP3Nm7cIvaFkQ2VH30-HDSOUb1hL1At0RQinTUuFuESvSnkghEkm1QW6ZFwI0Sp6hX599Gk42NEPEDBEgxcNNYW09wO2ztmhFpwcnlI4HX08hemUcwrepGibPxmmyRrs5hBsttHinSQYXLUZp7wCzeijLzVD9SneoJcOQrGvz_sa_fx8-2P3tbm7__Jt9-Gu8Vzw2hjTDopDawDsthuUpb2DJbdkrGW0dVtgXcekEYwC8L43SnY9o1siCHGdEPwavXvmTjn9nm2pevRlsCFAtGkumnIqOKetkIv17dk696M1esp-hHzS_wpaDN-fDT7ubaygH9Kc45Je-0Hv09HrteS1Y32UKlLNCKNkOdSUbJU21sEcqq6Q9f5Rl24BfvoP8C9tOkAe4VGvb1zQ60h1FoRqyHUVHX8CmW2XEA</recordid><startdate>20130101</startdate><enddate>20130101</enddate><creator>Yamashita</creator><creator>Yoshioka</creator><creator>Pan</creator><creator>Taira</creator><creator>Ogura</creator><creator>Nagano</creator><creator>Aoyama</creator><creator>Nagano</creator><creator>Abe</creator><creator>Kamada</creator><creator>Tsunoda, S.-I.</creator><creator>Aoshima</creator><creator>Nabeshi</creator><creator>Yoshikawa</creator><creator>Tsutsumi</creator><general>Govi-Verlag</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>20130101</creationdate><title>Biochemical and hematologic effects of polyvinylpyrrolidone-wrapped fullerene C60 after oral administration</title><author>Yamashita ; 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However, knowledge regarding the safety of fullerene C60, especially after oral administration, is sparse. Here,
we examined the safety of fullerene C60 in mice after 7 d of exposure to orally administered polyvinylpyrrolidone (PVP)-wrapped fullerene C60 (PVP-fullerene C60). Mice treated with PVP-fullerene C60 showed few changes in the plasma levels of various
markers of kidney and liver injury and experienced no significant hematologic effects. Furthermore, the histology of the colon of PVP-fullerene C60 -treated mice was indistinguishable from that of control mice. These results suggest that PVP-fullerene C60 lacks toxicity
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| subjects | Acute Kidney Injury - chemically induced Acute Kidney Injury - pathology Administration, Oral Animals Blood Cell Count Chemical and Drug Induced Liver Injury - pathology Colitis - chemically induced Colitis - pathology Female Fullerenes - administration & dosage Fullerenes - pharmacology Light Mice Mice, Inbred C57BL Povidone Scattering, Radiation Tissue Fixation |
| title | Biochemical and hematologic effects of polyvinylpyrrolidone-wrapped fullerene C60 after oral administration |
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