Essential requirement for IRF8 and SLC15A4 implicates plasmacytoid dendritic cells in the pathogenesis of lupus

In vitro evidence suggests that plasmacytoid dendritic cells (pDCs) are intimately involved in the pathogenesis of lupus. However, it remains to be determined whether these cells are required in vivo for disease development, and whether their contribution is restricted to hyperproduction of type I I...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-02, Vol.110 (8), p.2940-2945
Hauptverfasser:	Baccala, Roberto, Gonzalez-Quintial, Rosana, Blasius, Amanda L., Rimann, Ivo, Ozato, Keiko, Kono, Dwight H., Beutler, Bruce, Theofilopoulos, Argyrios N.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autoantibodies Autoimmune diseases Autoimmunity B lymphocytes Biological Sciences Cells Chromatin Dendritic cells Dendritic Cells - immunology Interferon Regulatory Factors - genetics Interferon Regulatory Factors - physiology Ligands Lupus Lupus Erythematosus, Systemic - immunology Membrane Transport Proteins - physiology Mice Mice, Inbred C57BL Mice, Knockout Mutation Pathogenesis Peptides Rodents Spleen Systemic lupus erythematosus T lymphocytes
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