Interaction of dependent and non-dependent regions of the acutely injured lung during a stepwise recruitment manoeuvre
The benefit of treating acute lung injury with recruitment manoeuvres is controversial. An impediment to settling this debate is the difficulty in visualizing how distinct lung regions respond to the manoeuvre. Here, regional lung mechanics were studied by electrical impedance tomography (EIT) durin...
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| Veröffentlicht in: | Physiological measurement 2013-02, Vol.34 (2), p.163-177 |
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| creator | Gómez-Laberge, Camille Rettig, Jordan S Smallwood, Craig D Boyd, Theonia K Arnold, John H Wolf, Gerhard K |
| description | The benefit of treating acute lung injury with recruitment manoeuvres is controversial. An impediment to settling this debate is the difficulty in visualizing how distinct lung regions respond to the manoeuvre. Here, regional lung mechanics were studied by electrical impedance tomography (EIT) during a stepwise recruitment manoeuvre in a porcine model with acute lung injury. The following interaction between dependent and non-dependent regions consistently occurred: atelectasis in the most dependent region was reversed only after the non-dependent region became overdistended. EIT estimates of overdistension and atelectasis were validated by histological examination of lung tissue, confirming that the dependent region was primarily atelectatic and the non-dependent region was primarily overdistended. The pulmonary pressure-volume equation, originally designed for modelling measurements at the airway opening, was adapted for EIT-based regional estimates of overdistension and atelectasis. The adaptation accurately modelled the regional EIT data from dependent and non-dependent regions (R2 > 0.93, P < 0.0001) and predicted their interaction during recruitment. In conclusion, EIT imaging of regional lung mechanics reveals that overdistension in the non-dependent region precedes atelectasis reversal in the dependent region during a stepwise recruitment manoeuvre. |
| doi_str_mv | 10.1088/0967-3334/34/2/163 |
| format | Article |
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An impediment to settling this debate is the difficulty in visualizing how distinct lung regions respond to the manoeuvre. Here, regional lung mechanics were studied by electrical impedance tomography (EIT) during a stepwise recruitment manoeuvre in a porcine model with acute lung injury. The following interaction between dependent and non-dependent regions consistently occurred: atelectasis in the most dependent region was reversed only after the non-dependent region became overdistended. EIT estimates of overdistension and atelectasis were validated by histological examination of lung tissue, confirming that the dependent region was primarily atelectatic and the non-dependent region was primarily overdistended. The pulmonary pressure-volume equation, originally designed for modelling measurements at the airway opening, was adapted for EIT-based regional estimates of overdistension and atelectasis. The adaptation accurately modelled the regional EIT data from dependent and non-dependent regions (R2 > 0.93, P < 0.0001) and predicted their interaction during recruitment. In conclusion, EIT imaging of regional lung mechanics reveals that overdistension in the non-dependent region precedes atelectasis reversal in the dependent region during a stepwise recruitment manoeuvre.</description><identifier>ISSN: 0967-3334</identifier><identifier>EISSN: 1361-6579</identifier><identifier>DOI: 10.1088/0967-3334/34/2/163</identifier><identifier>PMID: 23348518</identifier><identifier>CODEN: PMEAE3</identifier><language>eng</language><publisher>England: IOP Publishing</publisher><subject>acute lung injury ; Acute Lung Injury - diagnosis ; Acute Lung Injury - physiopathology ; Acute Lung Injury - rehabilitation ; acute respiratory distress syndrome ; Algorithms ; Animals ; Cardiography, Impedance - methods ; electrical impedance tomography ; Lung - physiopathology ; lung recruitment ; mechanical ventilation ; Positive-Pressure Respiration - adverse effects ; Positive-Pressure Respiration - methods ; Pulmonary Atelectasis - diagnosis ; Pulmonary Atelectasis - etiology ; Pulmonary Atelectasis - physiopathology ; Swine ; Treatment Outcome</subject><ispartof>Physiological measurement, 2013-02, Vol.34 (2), p.163-177</ispartof><rights>2013 Institute of Physics and Engineering in Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c342t-1edc6cc09eb5ae55e8c5d4cf86c6a074c74fa5f929187997e176ae1676da2a933</citedby><cites>FETCH-LOGICAL-c342t-1edc6cc09eb5ae55e8c5d4cf86c6a074c74fa5f929187997e176ae1676da2a933</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://iopscience.iop.org/article/10.1088/0967-3334/34/2/163/pdf$$EPDF$$P50$$Giop$$H</linktopdf><link.rule.ids>314,777,781,27905,27906,53827,53874</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23348518$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gómez-Laberge, Camille</creatorcontrib><creatorcontrib>Rettig, Jordan S</creatorcontrib><creatorcontrib>Smallwood, Craig D</creatorcontrib><creatorcontrib>Boyd, Theonia K</creatorcontrib><creatorcontrib>Arnold, John H</creatorcontrib><creatorcontrib>Wolf, Gerhard K</creatorcontrib><title>Interaction of dependent and non-dependent regions of the acutely injured lung during a stepwise recruitment manoeuvre</title><title>Physiological measurement</title><addtitle>PM</addtitle><addtitle>Physiol. Meas</addtitle><description>The benefit of treating acute lung injury with recruitment manoeuvres is controversial. An impediment to settling this debate is the difficulty in visualizing how distinct lung regions respond to the manoeuvre. Here, regional lung mechanics were studied by electrical impedance tomography (EIT) during a stepwise recruitment manoeuvre in a porcine model with acute lung injury. The following interaction between dependent and non-dependent regions consistently occurred: atelectasis in the most dependent region was reversed only after the non-dependent region became overdistended. EIT estimates of overdistension and atelectasis were validated by histological examination of lung tissue, confirming that the dependent region was primarily atelectatic and the non-dependent region was primarily overdistended. The pulmonary pressure-volume equation, originally designed for modelling measurements at the airway opening, was adapted for EIT-based regional estimates of overdistension and atelectasis. The adaptation accurately modelled the regional EIT data from dependent and non-dependent regions (R2 > 0.93, P < 0.0001) and predicted their interaction during recruitment. In conclusion, EIT imaging of regional lung mechanics reveals that overdistension in the non-dependent region precedes atelectasis reversal in the dependent region during a stepwise recruitment manoeuvre.</description><subject>acute lung injury</subject><subject>Acute Lung Injury - diagnosis</subject><subject>Acute Lung Injury - physiopathology</subject><subject>Acute Lung Injury - rehabilitation</subject><subject>acute respiratory distress syndrome</subject><subject>Algorithms</subject><subject>Animals</subject><subject>Cardiography, Impedance - methods</subject><subject>electrical impedance tomography</subject><subject>Lung - physiopathology</subject><subject>lung recruitment</subject><subject>mechanical ventilation</subject><subject>Positive-Pressure Respiration - adverse effects</subject><subject>Positive-Pressure Respiration - methods</subject><subject>Pulmonary Atelectasis - diagnosis</subject><subject>Pulmonary Atelectasis - etiology</subject><subject>Pulmonary Atelectasis - physiopathology</subject><subject>Swine</subject><subject>Treatment Outcome</subject><issn>0967-3334</issn><issn>1361-6579</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kE1LHTEUhkOp1Fv1D3RRsuxmvJNk8rUsUltBcFPXISZn7Fxmkmk-LP77ZrjW7oQDBw7P-8J5EPpE-kvSK7XvtZAdY2zYt6F7Itg7tCNMkE5wqd-j3Stwij7mfOh7QhTlH9ApbTfFidqhp5tQIFlXphhwHLGHFYKHULANHocYuv-XBI-NyhtWfgG2rhaYn_EUDjWBx3MNj9jXNLVlcS6w_pkytJRLdSrL1rDYEKE-JThHJ6OdM1y87DN0f_3t59WP7vbu-83V19vOsYGWjoB3wrlewwO3wDkox_3gRiWcsL0cnBxGy0dNNVFSawlECgtESOEttZqxM_Tl2Lum-LtCLmaZsoN5tgFizYZQxSTVmpOG0iPqUsw5wWjWNC02PRvSm8232XSaTadpQ03z3UKfX_rrwwL-NfJPcAMuj8AUV3OINYX27luNfwH2L4uw</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>Gómez-Laberge, Camille</creator><creator>Rettig, Jordan S</creator><creator>Smallwood, Craig D</creator><creator>Boyd, Theonia K</creator><creator>Arnold, John H</creator><creator>Wolf, Gerhard K</creator><general>IOP Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130201</creationdate><title>Interaction of dependent and non-dependent regions of the acutely injured lung during a stepwise recruitment manoeuvre</title><author>Gómez-Laberge, Camille ; Rettig, Jordan S ; Smallwood, Craig D ; Boyd, Theonia K ; Arnold, John H ; Wolf, Gerhard K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c342t-1edc6cc09eb5ae55e8c5d4cf86c6a074c74fa5f929187997e176ae1676da2a933</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>acute lung injury</topic><topic>Acute Lung Injury - diagnosis</topic><topic>Acute Lung Injury - physiopathology</topic><topic>Acute Lung Injury - rehabilitation</topic><topic>acute respiratory distress syndrome</topic><topic>Algorithms</topic><topic>Animals</topic><topic>Cardiography, Impedance - methods</topic><topic>electrical impedance tomography</topic><topic>Lung - physiopathology</topic><topic>lung recruitment</topic><topic>mechanical ventilation</topic><topic>Positive-Pressure Respiration - adverse effects</topic><topic>Positive-Pressure Respiration - methods</topic><topic>Pulmonary Atelectasis - diagnosis</topic><topic>Pulmonary Atelectasis - etiology</topic><topic>Pulmonary Atelectasis - physiopathology</topic><topic>Swine</topic><topic>Treatment Outcome</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gómez-Laberge, Camille</creatorcontrib><creatorcontrib>Rettig, Jordan S</creatorcontrib><creatorcontrib>Smallwood, Craig D</creatorcontrib><creatorcontrib>Boyd, Theonia K</creatorcontrib><creatorcontrib>Arnold, John H</creatorcontrib><creatorcontrib>Wolf, Gerhard K</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Physiological measurement</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gómez-Laberge, Camille</au><au>Rettig, Jordan S</au><au>Smallwood, Craig D</au><au>Boyd, Theonia K</au><au>Arnold, John H</au><au>Wolf, Gerhard K</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Interaction of dependent and non-dependent regions of the acutely injured lung during a stepwise recruitment manoeuvre</atitle><jtitle>Physiological measurement</jtitle><stitle>PM</stitle><addtitle>Physiol. Meas</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>34</volume><issue>2</issue><spage>163</spage><epage>177</epage><pages>163-177</pages><issn>0967-3334</issn><eissn>1361-6579</eissn><coden>PMEAE3</coden><abstract>The benefit of treating acute lung injury with recruitment manoeuvres is controversial. An impediment to settling this debate is the difficulty in visualizing how distinct lung regions respond to the manoeuvre. Here, regional lung mechanics were studied by electrical impedance tomography (EIT) during a stepwise recruitment manoeuvre in a porcine model with acute lung injury. The following interaction between dependent and non-dependent regions consistently occurred: atelectasis in the most dependent region was reversed only after the non-dependent region became overdistended. EIT estimates of overdistension and atelectasis were validated by histological examination of lung tissue, confirming that the dependent region was primarily atelectatic and the non-dependent region was primarily overdistended. The pulmonary pressure-volume equation, originally designed for modelling measurements at the airway opening, was adapted for EIT-based regional estimates of overdistension and atelectasis. The adaptation accurately modelled the regional EIT data from dependent and non-dependent regions (R2 > 0.93, P < 0.0001) and predicted their interaction during recruitment. In conclusion, EIT imaging of regional lung mechanics reveals that overdistension in the non-dependent region precedes atelectasis reversal in the dependent region during a stepwise recruitment manoeuvre.</abstract><cop>England</cop><pub>IOP Publishing</pub><pmid>23348518</pmid><doi>10.1088/0967-3334/34/2/163</doi><tpages>15</tpages></addata></record> |
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| source | MEDLINE; IOP Publishing Journals; Institute of Physics (IOP) Journals - HEAL-Link |
| subjects | acute lung injury Acute Lung Injury - diagnosis Acute Lung Injury - physiopathology Acute Lung Injury - rehabilitation acute respiratory distress syndrome Algorithms Animals Cardiography, Impedance - methods electrical impedance tomography Lung - physiopathology lung recruitment mechanical ventilation Positive-Pressure Respiration - adverse effects Positive-Pressure Respiration - methods Pulmonary Atelectasis - diagnosis Pulmonary Atelectasis - etiology Pulmonary Atelectasis - physiopathology Swine Treatment Outcome |
| title | Interaction of dependent and non-dependent regions of the acutely injured lung during a stepwise recruitment manoeuvre |
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