Antimony-resistant but not antimony-sensitive Leishmania donovani up-regulates host IL-10 to overexpress multidrug-resistant protein 1

The molecular mechanism of antimony-resistant Leishmania donovani (Sb ᴿLD)–driven up-regulation of IL-10 and multidrug-resistant protein 1 (MDR1) in infected macrophages (Mϕs) has been investigated. This study showed that both promastigote and amastigote forms of Sb ᴿLD, but not the antimony-sensiti...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-02, Vol.110 (7), p.E575-E582
Hauptverfasser:	Mukherjee, Budhaditya, Mukhopadhyay, Rupkatha, Bannerjee, Bijoylaxmi, Chowdhury, Sayan, Mukherjee, Sandip, Naskar, Kshudiram, Allam, Uday Sankar, Chakravortty, Dipshikha, Sundar, Shyam, Dujardin, Jean-Claude, Roy, Syamal
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimony ATP-Binding Cassette, Sub-Family B, Member 1 - immunology ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Bacterial proteins Biological Sciences Blotting, Western Chromatin Immunoprecipitation Cricetinae Cytokines DNA Primers - genetics Drug resistance Drug Resistance - immunology Electrophoretic Mobility Shift Assay Flow Cytometry Gene Expression Regulation - immunology Immunoprecipitation Interleukin-10 - genetics Interleukin-10 - immunology Interleukin-10 - metabolism Leishmania donovani - immunology Macrophages Mesocricetus Mice Mice, Inbred BALB C Mice, Knockout Parasitic protozoa Phosphorylation PNAS Plus Proto-Oncogene Proteins c-fos - immunology Reverse Transcriptase Polymerase Chain Reaction Signal Transduction - immunology T cell receptors Toll-Like Receptor 2 - immunology Toll-Like Receptor 6 - immunology
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