Microwave-assisted synthesis of new benzimidazole derivatives with lipase inhibition activity

Abstract A practical protocol has been used for the synthesis of benzimidazoles. The reaction of iminoester hydrochlorides of phenylacetic with 4,5-dichloro-1,2-phenylenediamine under microwave irradiation leads to the benzimidazole derivatives with good yields and in short reaction times. After the...

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Veröffentlicht in:	Journal of enzyme inhibition and medicinal chemistry 2014-02, Vol.29 (1), p.64-68
Hauptverfasser:	Mente e, Emre, Bekta, Hakan, Ülker, Serdar, Bekircan, Olcay, Kahveci, Bahittin
Format:	Artikel
Sprache:	eng
Schlagworte:	Benzimidazole Benzimidazoles - chemical synthesis Benzimidazoles - pharmacology Enzyme Inhibitors - pharmacology iminoester hydrochloride Lipase - antagonists & inhibitors lipase inhibition Magnetic Resonance Spectroscopy Mass Spectrometry microwave Microwaves Spectrophotometry, Infrared
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