Structure and inhibition of the drug-resistant S31N mutant of the M2 ion channel of influenza A virus

The influenza A virus M2 proton channel (A/M2) is the target of the antiviral drugs amantadine and rimantadine, whose use has been discontinued due to widespread drug resistance. Among the handful of drug-resistant mutants, S31N is found in more than 95% of the currently circulating viruses and show...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-01, Vol.110 (4), p.1315-1320
Hauptverfasser:	Wang, Jun, Wu, Yibing, Ma, Chunlong, Fiorin, Giacomo, Wang, Jizhou, Pinto, Lawrence H., Lamb, Robert A., Klein, Michael L., DeGrado, William F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amantadine - analogs & derivatives Amantadine - chemical synthesis Amantadine - chemistry Amantadine - pharmacology Amines antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - chemistry Antiviral Agents - pharmacology Antiviral drugs Antivirals Binding Sites Biological Sciences Drug Design Drug interactions Drug resistance Drug Resistance, Viral - genetics drugs Genes, Fungal Humans Influenza Influenza A virus Influenza A virus - chemistry Influenza A virus - drug effects Influenza A virus - genetics Inhibitor drugs Ion channels Models, Molecular molecular dynamics Molecular structure Molecules mutants Mutation nuclear magnetic resonance spectroscopy Nuclear Magnetic Resonance, Biomolecular Physical Sciences Protons Quaternary ammonium compounds Recombinant Proteins - antagonists & inhibitors Recombinant Proteins - chemistry Recombinant Proteins - genetics Structure-Activity Relationship Viral Matrix Proteins - antagonists & inhibitors Viral Matrix Proteins - chemistry Viral Matrix Proteins - genetics Viruses
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