Annual cost of hospitalization, inpatient rehabilitation and sick leave of anal cancer in Germany
Abstract Objective: Literature on the economic burden of anal cancer in Germany is scarce. About 84% of these cancers are associated with human papillomavirus infection. This study, therefore, aimed to assess the annual costs of human papillomavirus-related anal cancer incurred by hospitalization, i...
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| Veröffentlicht in: | Journal of medical economics 2013-03, Vol.16 (3), p.364-371 |
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| container_title | Journal of medical economics |
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| creator | Heitland, Wolf Schädlich, Peter K. Chen, Xiaoyu Rémy, Vanessa Moro, Lionel |
| description | Abstract
Objective:
Literature on the economic burden of anal cancer in Germany is scarce. About 84% of these cancers are associated with human papillomavirus infection. This study, therefore, aimed to assess the annual costs of human papillomavirus-related anal cancer incurred by hospitalization, inpatient rehabilitation, and sick leave in 2008 in Germany.
Methods:
A cross-sectional retrospective analysis of five German databases covering hospital treatment, inpatient rehabilitation, and sick leave in 2008 was performed. All hospital, inpatient rehabilitation, and sick leave cases due to anal cancer in 2008 were analyzed. Associated numbers of anal cancer hospitalizations, healthcare resource use, and costs were identified and extracted using the ICD-10 code C21 as the main diagnosis. The annual cost of human papillomavirus-related anal cancer was estimated based on the percentage of anal cancer likely to be attributable to human papillomavirus.
Results:
In 2008, there were 5774 hospitalizations (39% males, 61% females), 517 inpatient rehabilitations, and 897 sick leaves due to anal cancer representing costs of €34.11 million. The estimated annual costs associated with human papillomavirus-related anal cancer were €28.72 million, mainly attributed to females (62%). Direct costs accounted for 90% (86% for hospital treatment, 4% for inpatient rehabilitation) and indirect costs due to sick leave accounted for 10% of human papillomavirus-related costs.
Conclusions:
The economic burden of human papillomavirus-related anal cancer in 2008 in Germany is under-estimated, since costs incurred by outpatient management, outpatient chemotherapy, long-term care, premature retirement, and premature death were not included. However, this study is the first analysis to investigate the economic burden of anal cancer in Germany. The estimated annual costs of human papillomavirus-related anal cancer contribute to a significant economic burden in Germany and should be considered when assessing health and economic benefits of human papillomavirus vaccination in both genders. |
| doi_str_mv | 10.3111/13696998.2012.759582 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_23253056</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1287886163</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3792-ac36181d6a2fd90dd0f21401409767b079463217e5cb14cfb67835e7912bb8053</originalsourceid><addsrcrecordid>eNp9kFFrFTEQhYNYbGn7D0Ty6IN7zSS7yeZFKaVWoeCLgm9hNpvlpuYm12RXuf31Zrmt4EtDIANzzpnJR8hrYBsBAO9BSC217jecAd-oTnc9f0HOQLfQ9EL9eFnrKmlWzSm5LOWe1SMEMAWvyCkXvBOsk2cEr2JcMFCbykzTRLep7P2MwT_g7FN8R33c18rFmWa3xcGH2l07FONIi7c_aXD4261ejGsQRutytdFbl3cYDxfkZMJQ3OXje06-f7r5dv25uft6--X66q6xQmneoBUSehgl8mnUbBzZxKFl9Wol1cCUbqXgoFxnB2jtNEjVi84pDXwYetaJc_L2mLvP6dfiymx2vlgXAkaXlmKA96rvJUhRpe1RanMqJbvJ7LPfYT4YYGbla574mpWvOfKttjePE5Zh58Z_pieaVfDxKPBxSvXzf1IOo5nxEFKecgXjS41_fsSH_xK2DsO8tZiduU9LroDL8zv-BfgEnGY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1287886163</pqid></control><display><type>article</type><title>Annual cost of hospitalization, inpatient rehabilitation and sick leave of anal cancer in Germany</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><creator>Heitland, Wolf ; Schädlich, Peter K. ; Chen, Xiaoyu ; Rémy, Vanessa ; Moro, Lionel</creator><creatorcontrib>Heitland, Wolf ; Schädlich, Peter K. ; Chen, Xiaoyu ; Rémy, Vanessa ; Moro, Lionel</creatorcontrib><description>Abstract
Objective:
Literature on the economic burden of anal cancer in Germany is scarce. About 84% of these cancers are associated with human papillomavirus infection. This study, therefore, aimed to assess the annual costs of human papillomavirus-related anal cancer incurred by hospitalization, inpatient rehabilitation, and sick leave in 2008 in Germany.
Methods:
A cross-sectional retrospective analysis of five German databases covering hospital treatment, inpatient rehabilitation, and sick leave in 2008 was performed. All hospital, inpatient rehabilitation, and sick leave cases due to anal cancer in 2008 were analyzed. Associated numbers of anal cancer hospitalizations, healthcare resource use, and costs were identified and extracted using the ICD-10 code C21 as the main diagnosis. The annual cost of human papillomavirus-related anal cancer was estimated based on the percentage of anal cancer likely to be attributable to human papillomavirus.
Results:
In 2008, there were 5774 hospitalizations (39% males, 61% females), 517 inpatient rehabilitations, and 897 sick leaves due to anal cancer representing costs of €34.11 million. The estimated annual costs associated with human papillomavirus-related anal cancer were €28.72 million, mainly attributed to females (62%). Direct costs accounted for 90% (86% for hospital treatment, 4% for inpatient rehabilitation) and indirect costs due to sick leave accounted for 10% of human papillomavirus-related costs.
Conclusions:
The economic burden of human papillomavirus-related anal cancer in 2008 in Germany is under-estimated, since costs incurred by outpatient management, outpatient chemotherapy, long-term care, premature retirement, and premature death were not included. However, this study is the first analysis to investigate the economic burden of anal cancer in Germany. The estimated annual costs of human papillomavirus-related anal cancer contribute to a significant economic burden in Germany and should be considered when assessing health and economic benefits of human papillomavirus vaccination in both genders.</description><identifier>ISSN: 1369-6998</identifier><identifier>EISSN: 1941-837X</identifier><identifier>DOI: 10.3111/13696998.2012.759582</identifier><identifier>PMID: 23253056</identifier><language>eng</language><publisher>England: Informa UK, Ltd</publisher><subject>Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anal cancer ; Anus Neoplasms - economics ; Anus Neoplasms - rehabilitation ; Anus Neoplasms - virology ; Cost of illness ; Costs and Cost Analysis ; Cross-Sectional Studies ; Databases, Factual ; Female ; Germany ; Hospitalization - economics ; Human papillomavirus ; Humans ; Male ; Middle Aged ; Papillomavirus Infections - complications ; Papillomavirus Infections - economics ; Retrospective Studies ; Sex Distribution ; Sick Leave - economics ; Young Adult</subject><ispartof>Journal of medical economics, 2013-03, Vol.16 (3), p.364-371</ispartof><rights>2013 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3792-ac36181d6a2fd90dd0f21401409767b079463217e5cb14cfb67835e7912bb8053</citedby><cites>FETCH-LOGICAL-c3792-ac36181d6a2fd90dd0f21401409767b079463217e5cb14cfb67835e7912bb8053</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23253056$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Heitland, Wolf</creatorcontrib><creatorcontrib>Schädlich, Peter K.</creatorcontrib><creatorcontrib>Chen, Xiaoyu</creatorcontrib><creatorcontrib>Rémy, Vanessa</creatorcontrib><creatorcontrib>Moro, Lionel</creatorcontrib><title>Annual cost of hospitalization, inpatient rehabilitation and sick leave of anal cancer in Germany</title><title>Journal of medical economics</title><addtitle>J Med Econ</addtitle><description>Abstract
Objective:
Literature on the economic burden of anal cancer in Germany is scarce. About 84% of these cancers are associated with human papillomavirus infection. This study, therefore, aimed to assess the annual costs of human papillomavirus-related anal cancer incurred by hospitalization, inpatient rehabilitation, and sick leave in 2008 in Germany.
Methods:
A cross-sectional retrospective analysis of five German databases covering hospital treatment, inpatient rehabilitation, and sick leave in 2008 was performed. All hospital, inpatient rehabilitation, and sick leave cases due to anal cancer in 2008 were analyzed. Associated numbers of anal cancer hospitalizations, healthcare resource use, and costs were identified and extracted using the ICD-10 code C21 as the main diagnosis. The annual cost of human papillomavirus-related anal cancer was estimated based on the percentage of anal cancer likely to be attributable to human papillomavirus.
Results:
In 2008, there were 5774 hospitalizations (39% males, 61% females), 517 inpatient rehabilitations, and 897 sick leaves due to anal cancer representing costs of €34.11 million. The estimated annual costs associated with human papillomavirus-related anal cancer were €28.72 million, mainly attributed to females (62%). Direct costs accounted for 90% (86% for hospital treatment, 4% for inpatient rehabilitation) and indirect costs due to sick leave accounted for 10% of human papillomavirus-related costs.
Conclusions:
The economic burden of human papillomavirus-related anal cancer in 2008 in Germany is under-estimated, since costs incurred by outpatient management, outpatient chemotherapy, long-term care, premature retirement, and premature death were not included. However, this study is the first analysis to investigate the economic burden of anal cancer in Germany. The estimated annual costs of human papillomavirus-related anal cancer contribute to a significant economic burden in Germany and should be considered when assessing health and economic benefits of human papillomavirus vaccination in both genders.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anal cancer</subject><subject>Anus Neoplasms - economics</subject><subject>Anus Neoplasms - rehabilitation</subject><subject>Anus Neoplasms - virology</subject><subject>Cost of illness</subject><subject>Costs and Cost Analysis</subject><subject>Cross-Sectional Studies</subject><subject>Databases, Factual</subject><subject>Female</subject><subject>Germany</subject><subject>Hospitalization - economics</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Papillomavirus Infections - complications</subject><subject>Papillomavirus Infections - economics</subject><subject>Retrospective Studies</subject><subject>Sex Distribution</subject><subject>Sick Leave - economics</subject><subject>Young Adult</subject><issn>1369-6998</issn><issn>1941-837X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kFFrFTEQhYNYbGn7D0Ty6IN7zSS7yeZFKaVWoeCLgm9hNpvlpuYm12RXuf31Zrmt4EtDIANzzpnJR8hrYBsBAO9BSC217jecAd-oTnc9f0HOQLfQ9EL9eFnrKmlWzSm5LOWe1SMEMAWvyCkXvBOsk2cEr2JcMFCbykzTRLep7P2MwT_g7FN8R33c18rFmWa3xcGH2l07FONIi7c_aXD4261ejGsQRutytdFbl3cYDxfkZMJQ3OXje06-f7r5dv25uft6--X66q6xQmneoBUSehgl8mnUbBzZxKFl9Wol1cCUbqXgoFxnB2jtNEjVi84pDXwYetaJc_L2mLvP6dfiymx2vlgXAkaXlmKA96rvJUhRpe1RanMqJbvJ7LPfYT4YYGbla574mpWvOfKttjePE5Zh58Z_pieaVfDxKPBxSvXzf1IOo5nxEFKecgXjS41_fsSH_xK2DsO8tZiduU9LroDL8zv-BfgEnGY</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Heitland, Wolf</creator><creator>Schädlich, Peter K.</creator><creator>Chen, Xiaoyu</creator><creator>Rémy, Vanessa</creator><creator>Moro, Lionel</creator><general>Informa UK, Ltd</general><general>Taylor & Francis</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20130301</creationdate><title>Annual cost of hospitalization, inpatient rehabilitation and sick leave of anal cancer in Germany</title><author>Heitland, Wolf ; Schädlich, Peter K. ; Chen, Xiaoyu ; Rémy, Vanessa ; Moro, Lionel</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3792-ac36181d6a2fd90dd0f21401409767b079463217e5cb14cfb67835e7912bb8053</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anal cancer</topic><topic>Anus Neoplasms - economics</topic><topic>Anus Neoplasms - rehabilitation</topic><topic>Anus Neoplasms - virology</topic><topic>Cost of illness</topic><topic>Costs and Cost Analysis</topic><topic>Cross-Sectional Studies</topic><topic>Databases, Factual</topic><topic>Female</topic><topic>Germany</topic><topic>Hospitalization - economics</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Papillomavirus Infections - complications</topic><topic>Papillomavirus Infections - economics</topic><topic>Retrospective Studies</topic><topic>Sex Distribution</topic><topic>Sick Leave - economics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Heitland, Wolf</creatorcontrib><creatorcontrib>Schädlich, Peter K.</creatorcontrib><creatorcontrib>Chen, Xiaoyu</creatorcontrib><creatorcontrib>Rémy, Vanessa</creatorcontrib><creatorcontrib>Moro, Lionel</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of medical economics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Heitland, Wolf</au><au>Schädlich, Peter K.</au><au>Chen, Xiaoyu</au><au>Rémy, Vanessa</au><au>Moro, Lionel</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Annual cost of hospitalization, inpatient rehabilitation and sick leave of anal cancer in Germany</atitle><jtitle>Journal of medical economics</jtitle><addtitle>J Med Econ</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>16</volume><issue>3</issue><spage>364</spage><epage>371</epage><pages>364-371</pages><issn>1369-6998</issn><eissn>1941-837X</eissn><abstract>Abstract
Objective:
Literature on the economic burden of anal cancer in Germany is scarce. About 84% of these cancers are associated with human papillomavirus infection. This study, therefore, aimed to assess the annual costs of human papillomavirus-related anal cancer incurred by hospitalization, inpatient rehabilitation, and sick leave in 2008 in Germany.
Methods:
A cross-sectional retrospective analysis of five German databases covering hospital treatment, inpatient rehabilitation, and sick leave in 2008 was performed. All hospital, inpatient rehabilitation, and sick leave cases due to anal cancer in 2008 were analyzed. Associated numbers of anal cancer hospitalizations, healthcare resource use, and costs were identified and extracted using the ICD-10 code C21 as the main diagnosis. The annual cost of human papillomavirus-related anal cancer was estimated based on the percentage of anal cancer likely to be attributable to human papillomavirus.
Results:
In 2008, there were 5774 hospitalizations (39% males, 61% females), 517 inpatient rehabilitations, and 897 sick leaves due to anal cancer representing costs of €34.11 million. The estimated annual costs associated with human papillomavirus-related anal cancer were €28.72 million, mainly attributed to females (62%). Direct costs accounted for 90% (86% for hospital treatment, 4% for inpatient rehabilitation) and indirect costs due to sick leave accounted for 10% of human papillomavirus-related costs.
Conclusions:
The economic burden of human papillomavirus-related anal cancer in 2008 in Germany is under-estimated, since costs incurred by outpatient management, outpatient chemotherapy, long-term care, premature retirement, and premature death were not included. However, this study is the first analysis to investigate the economic burden of anal cancer in Germany. The estimated annual costs of human papillomavirus-related anal cancer contribute to a significant economic burden in Germany and should be considered when assessing health and economic benefits of human papillomavirus vaccination in both genders.</abstract><cop>England</cop><pub>Informa UK, Ltd</pub><pmid>23253056</pmid><doi>10.3111/13696998.2012.759582</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Adult Aged Aged, 80 and over Anal cancer Anus Neoplasms - economics Anus Neoplasms - rehabilitation Anus Neoplasms - virology Cost of illness Costs and Cost Analysis Cross-Sectional Studies Databases, Factual Female Germany Hospitalization - economics Human papillomavirus Humans Male Middle Aged Papillomavirus Infections - complications Papillomavirus Infections - economics Retrospective Studies Sex Distribution Sick Leave - economics Young Adult |
| title | Annual cost of hospitalization, inpatient rehabilitation and sick leave of anal cancer in Germany |
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