Activation of 5-HT2A receptors upregulates the function of the neuronal K-Cl cotransporter KCC2

In healthy adults, activation of γ-aminobutyric acid (GABA) A and glycine receptors inhibits neurons as a result of low intracellular chloride concentration ([Cl –] ᵢ), which is maintained by the potassium-chloride cotransporter KCC2. A reduction of KCC2 expression or function is implicated in the p...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2013-01, Vol.110 (1), p.348-353
Hauptverfasser:	Bos, Rémi, Sadlaoud, Karina, Boulenguez, Pascale, Buttigieg, Dorothée, Liabeuf, Sylvie, Brocard, Cécile, Haase, Georg, Bras, Hélène, Vinay, Laurent
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Behavioral neuroscience Biological Sciences Blotting, Western Bridged Bicyclo Compounds - pharmacology Cell membranes Chlorides Chlorides - metabolism Gene expression Gene Expression Regulation - drug effects H-Reflex Homeostasis Immunohistochemistry Inhibitory Postsynaptic Potentials - physiology K Cl- Cotransporters Life Sciences Methylamines - pharmacology Motor Neurons - metabolism Muscle Spasticity - drug therapy Muscle Spasticity - etiology Neurobiology Neurochemistry Neurological disorders Neurons Neurons and Cognition Pain Pathology Proteins Rats Receptor, Serotonin, 5-HT2A - metabolism Receptors Serotonin Serotonin - metabolism Serotonin - pharmacology Serotonin 5-HT2 Receptor Agonists - pharmacology Serotonin receptors Spinal cord Spinal Cord Injuries - complications Spinal Nerve roots Symporters - metabolism
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!