Peroxiredoxin 1 knockdown potentiates β-lapachone cytotoxicity through modulation of reactive oxygen species and mitogen-activated protein kinase signals

Peroxiredoxin (Prx) 1 is a member of the thiol-specific peroxidases family and plays diverse roles such as H2O2 scavenger, redox signal transducer and molecular chaperone. Prx1 has been reported to be involved in protecting cancer cells against various therapeutic challenges. We investigated how mod...

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Veröffentlicht in:	Carcinogenesis (New York) 2013-04, Vol.34 (4), p.760
Hauptverfasser:	He, Tiantian, Banach-Latapy, Agata, Vernis, Laurence, Dardalhon, Michèle, Chanet, Roland, Huang, Meng-Er
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - physiology Cell Line, Tumor Extracellular Signal-Regulated MAP Kinases - metabolism HeLa Cells Humans Hydrogen Peroxide - metabolism JNK Mitogen-Activated Protein Kinases - metabolism MAP Kinase Signaling System NAD(P)H Dehydrogenase (Quinone) - metabolism Naphthoquinones - pharmacology Neoplasms - drug therapy Neoplasms - metabolism p38 Mitogen-Activated Protein Kinases - metabolism Peroxiredoxins - genetics Peroxiredoxins - metabolism Phosphorylation Poly (ADP-Ribose) Polymerase-1 Poly(ADP-ribose) Polymerases - biosynthesis Poly(ADP-ribose) Polymerases - metabolism Reactive Oxygen Species - metabolism Reverse Transcriptase Inhibitors - pharmacology RNA Interference RNA, Small Interfering Thioredoxins - metabolism
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