Recombinant Tumor Necrosis Factor-α Chronically Administered in Rats: Lack of Cachectic Effect
Abstract Recombinant human tumor necrosis factor-α (rHuTNF) was injected into rats to test its reported cachectic effects. Rats were subcutaneously injected daily at 1730 hr with either saline or rHuTNF (0.25 mg/kg body wt) for either 5 or 14 days. Daily food intakes were significantly depressed onl...
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| Veröffentlicht in: | Proceedings of the Society for Experimental Biology and Medicine 1990-04, Vol.193 (4), p.318-325 |
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| container_title | Proceedings of the Society for Experimental Biology and Medicine |
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| creator | Mullen, Barbara J. Harris, Ruth B. S. Patton, John S. Martin, Roy J. |
| description | Abstract
Recombinant human tumor necrosis factor-α (rHuTNF) was injected into rats to test its reported cachectic effects. Rats were subcutaneously injected daily at 1730 hr with either saline or rHuTNF (0.25 mg/kg body wt) for either 5 or 14 days. Daily food intakes were significantly depressed only for the first day and first two days of rHuTNF injection in animals treated for 5 days and 14 days, respectively. There were no significant differences in daily body weights among the groups. Analysis of carcass composition revealed no significant differences in percentage of lipid or protein. Liver and inguinal pad weights were not significantly different. In vitro determination of lipogenesis showed it was enhanced in the inguinal pad and depressed in the liver only after 14 days of treatment. These results demonstrate that although in vivo rHuTNF may specifically alter tissue metabolism, it does not, by itself, result in a sustained cachectic effect. |
| doi_str_mv | 10.3181/00379727-193-43042 |
| format | Article |
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Recombinant human tumor necrosis factor-α (rHuTNF) was injected into rats to test its reported cachectic effects. Rats were subcutaneously injected daily at 1730 hr with either saline or rHuTNF (0.25 mg/kg body wt) for either 5 or 14 days. Daily food intakes were significantly depressed only for the first day and first two days of rHuTNF injection in animals treated for 5 days and 14 days, respectively. There were no significant differences in daily body weights among the groups. Analysis of carcass composition revealed no significant differences in percentage of lipid or protein. Liver and inguinal pad weights were not significantly different. In vitro determination of lipogenesis showed it was enhanced in the inguinal pad and depressed in the liver only after 14 days of treatment. These results demonstrate that although in vivo rHuTNF may specifically alter tissue metabolism, it does not, by itself, result in a sustained cachectic effect.</description><identifier>ISSN: 0037-9727</identifier><identifier>EISSN: 1535-3699</identifier><identifier>EISSN: 1525-1373</identifier><identifier>DOI: 10.3181/00379727-193-43042</identifier><identifier>PMID: 2320602</identifier><identifier>CODEN: PSEBAA</identifier><language>eng</language><publisher>London, England: SAGE Publications</publisher><subject>Adipose Tissue - metabolism ; Animals ; Biological and medical sciences ; Body Composition - drug effects ; Body Weight - drug effects ; Cachexia - chemically induced ; Eating - drug effects ; Female ; Fundamental and applied biological sciences. Psychology ; Lipids - biosynthesis ; Liver - metabolism ; Organ Size - drug effects ; Rats ; Rats, Inbred Strains ; Recombinant Proteins - toxicity ; Triglycerides - biosynthesis ; Tumor Necrosis Factor-alpha - toxicity ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Proceedings of the Society for Experimental Biology and Medicine, 1990-04, Vol.193 (4), p.318-325</ispartof><rights>1993 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=4619659$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2320602$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Mullen, Barbara J.</creatorcontrib><creatorcontrib>Harris, Ruth B. S.</creatorcontrib><creatorcontrib>Patton, John S.</creatorcontrib><creatorcontrib>Martin, Roy J.</creatorcontrib><title>Recombinant Tumor Necrosis Factor-α Chronically Administered in Rats: Lack of Cachectic Effect</title><title>Proceedings of the Society for Experimental Biology and Medicine</title><addtitle>Proc Soc Exp Biol Med</addtitle><description>Abstract
Recombinant human tumor necrosis factor-α (rHuTNF) was injected into rats to test its reported cachectic effects. Rats were subcutaneously injected daily at 1730 hr with either saline or rHuTNF (0.25 mg/kg body wt) for either 5 or 14 days. Daily food intakes were significantly depressed only for the first day and first two days of rHuTNF injection in animals treated for 5 days and 14 days, respectively. There were no significant differences in daily body weights among the groups. Analysis of carcass composition revealed no significant differences in percentage of lipid or protein. Liver and inguinal pad weights were not significantly different. In vitro determination of lipogenesis showed it was enhanced in the inguinal pad and depressed in the liver only after 14 days of treatment. These results demonstrate that although in vivo rHuTNF may specifically alter tissue metabolism, it does not, by itself, result in a sustained cachectic effect.</description><subject>Adipose Tissue - metabolism</subject><subject>Animals</subject><subject>Biological and medical sciences</subject><subject>Body Composition - drug effects</subject><subject>Body Weight - drug effects</subject><subject>Cachexia - chemically induced</subject><subject>Eating - drug effects</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Lipids - biosynthesis</subject><subject>Liver - metabolism</subject><subject>Organ Size - drug effects</subject><subject>Rats</subject><subject>Rats, Inbred Strains</subject><subject>Recombinant Proteins - toxicity</subject><subject>Triglycerides - biosynthesis</subject><subject>Tumor Necrosis Factor-alpha - toxicity</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0037-9727</issn><issn>1535-3699</issn><issn>1525-1373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kM1KAzEURoMotVZfQBCycBub_0zcldKqUBRKXYc0k9jUzkxJpos-li_iMzm11dW98B0u9zsA3BL8wEhBhhgzpRVViGiGOMOcnoE-EUwgJrU-B_0DgA7EJbjKeY0xEYrKHuhRRrHEtA_M3LumWsba1i1c7KomwVfvUpNjhlPr2iah7y84XqWmjs5uNns4KqtYx9z65EsYazi3bX6EM-s-YRPg2LqVd210cBJCt1yDi2A32d-c5gC8TyeL8TOavT29jEcztKVKtMizIDBXillhaemVLgtGVMEKWRZcBKEVLhj1bikDl4FJJwkvZWmJo9ZxLtkA3B3vbnfLypdmm2Jl096cinb5_Sm3uesRkq1dzP8Yl0RLoTtseMSy_fBm3exS3X1tCDYH4eZPuOmEm1_h7AcK82_6</recordid><startdate>19900401</startdate><enddate>19900401</enddate><creator>Mullen, Barbara J.</creator><creator>Harris, Ruth B. S.</creator><creator>Patton, John S.</creator><creator>Martin, Roy J.</creator><general>SAGE Publications</general><general>Blackwell Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope></search><sort><creationdate>19900401</creationdate><title>Recombinant Tumor Necrosis Factor-α Chronically Administered in Rats: Lack of Cachectic Effect</title><author>Mullen, Barbara J. ; Harris, Ruth B. S. ; Patton, John S. ; Martin, Roy J.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p275t-e3f504773a5a2de79d83178386d845f5970832ecb6f46f36c614d6da1c2ac4463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adipose Tissue - metabolism</topic><topic>Animals</topic><topic>Biological and medical sciences</topic><topic>Body Composition - drug effects</topic><topic>Body Weight - drug effects</topic><topic>Cachexia - chemically induced</topic><topic>Eating - drug effects</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Lipids - biosynthesis</topic><topic>Liver - metabolism</topic><topic>Organ Size - drug effects</topic><topic>Rats</topic><topic>Rats, Inbred Strains</topic><topic>Recombinant Proteins - toxicity</topic><topic>Triglycerides - biosynthesis</topic><topic>Tumor Necrosis Factor-alpha - toxicity</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Mullen, Barbara J.</creatorcontrib><creatorcontrib>Harris, Ruth B. S.</creatorcontrib><creatorcontrib>Patton, John S.</creatorcontrib><creatorcontrib>Martin, Roy J.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><jtitle>Proceedings of the Society for Experimental Biology and Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Mullen, Barbara J.</au><au>Harris, Ruth B. S.</au><au>Patton, John S.</au><au>Martin, Roy J.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Recombinant Tumor Necrosis Factor-α Chronically Administered in Rats: Lack of Cachectic Effect</atitle><jtitle>Proceedings of the Society for Experimental Biology and Medicine</jtitle><addtitle>Proc Soc Exp Biol Med</addtitle><date>1990-04-01</date><risdate>1990</risdate><volume>193</volume><issue>4</issue><spage>318</spage><epage>325</epage><pages>318-325</pages><issn>0037-9727</issn><eissn>1535-3699</eissn><eissn>1525-1373</eissn><coden>PSEBAA</coden><abstract>Abstract
Recombinant human tumor necrosis factor-α (rHuTNF) was injected into rats to test its reported cachectic effects. Rats were subcutaneously injected daily at 1730 hr with either saline or rHuTNF (0.25 mg/kg body wt) for either 5 or 14 days. Daily food intakes were significantly depressed only for the first day and first two days of rHuTNF injection in animals treated for 5 days and 14 days, respectively. There were no significant differences in daily body weights among the groups. Analysis of carcass composition revealed no significant differences in percentage of lipid or protein. Liver and inguinal pad weights were not significantly different. In vitro determination of lipogenesis showed it was enhanced in the inguinal pad and depressed in the liver only after 14 days of treatment. These results demonstrate that although in vivo rHuTNF may specifically alter tissue metabolism, it does not, by itself, result in a sustained cachectic effect.</abstract><cop>London, England</cop><pub>SAGE Publications</pub><pmid>2320602</pmid><doi>10.3181/00379727-193-43042</doi><tpages>8</tpages></addata></record> |
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| ispartof | Proceedings of the Society for Experimental Biology and Medicine, 1990-04, Vol.193 (4), p.318-325 |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Adipose Tissue - metabolism Animals Biological and medical sciences Body Composition - drug effects Body Weight - drug effects Cachexia - chemically induced Eating - drug effects Female Fundamental and applied biological sciences. Psychology Lipids - biosynthesis Liver - metabolism Organ Size - drug effects Rats Rats, Inbred Strains Recombinant Proteins - toxicity Triglycerides - biosynthesis Tumor Necrosis Factor-alpha - toxicity Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Recombinant Tumor Necrosis Factor-α Chronically Administered in Rats: Lack of Cachectic Effect |
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