IL-17A/IL-17RA interaction promoted metastasis of osteosarcoma cells

Osteosarcoma (OS) is the most common human primary malignant bone tumor in children and young adults with poor prognosis because of their high metastatic potential. Identification of key factors that could regulate the aggressive biologic behavior of OS, particularly with respect to metastasis, woul...

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Veröffentlicht in:	Cancer biology & therapy 2013-02, Vol.14 (2), p.155-163
Hauptverfasser:	Wang, Mingmin, Wang, Luanqiu, Ren, Tao, Xu, Lin, Wen, Zhenke
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Animals Bone Neoplasms - genetics Bone Neoplasms - metabolism Bone Neoplasms - pathology Cell Line, Tumor Child Disease Models, Animal Female Gene Expression Regulation, Neoplastic Humans IL-17A IL-17RA Interleukin-17 - blood Interleukin-17 - metabolism Male Matrix Metalloproteinase 9 - genetics Matrix Metalloproteinase 9 - metabolism metastasis Mice Neoplasm Metastasis osteosarcoma Osteosarcoma - genetics Osteosarcoma - metabolism Osteosarcoma - pathology Protein Binding Receptors, CXCR4 - genetics Receptors, CXCR4 - metabolism Receptors, Interleukin-17 - metabolism Research Paper STAT3 Transcription Factor - metabolism Vascular Endothelial Growth Factors - genetics Vascular Endothelial Growth Factors - metabolism Young Adult
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