Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody

Affinity maturation refines a naive B-cell response by selecting mutations in antibody variable domains that enhance antigen binding. We describe a B-cell lineage expressing broadly neutralizing influenza virus antibodies derived from a subject immunized with the 2007 trivalent vaccine. The lineage...

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Veröffentlicht in:	Proc. Natl. Acad. Sci. USA 2013-01, Vol.110 (1), p.264-269
Hauptverfasser:	Schmidt, Aaron G., Xu, Huafeng, Khan, Amir R., O'Donnell, Timothy, Khurana, Surender, King, Lisa R., Manischewitz, Jody, Golding, Hana, Suphaphiphat, Pirada, Carfi, Andrea, Settembre, Ethan C., Dormitzer, Philip R., Kepler, Thomas B., Zhang, Ruijun, Moody, M. Anthony, Haynes, Barton F., Liao, Hua-Xin, Shaw, David E., Harrison, Stephen C.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Antibodies Antibodies, Neutralizing - chemistry Antibodies, Neutralizing - genetics Antibodies, Viral - genetics Antigens B lymphocytes B-Lymphocytes - immunology Binding Sites, Antibody - genetics Biological Sciences Cells Crystal structure Crystallography, X-Ray evolution Evolution, Molecular Force field Immunoglobulin Fab Fragments - chemistry Immunoglobulin Variable Region - genetics Influenza Influenza Vaccines - immunology Kinetics Modeling Models, Molecular molecular dynamics Molecular Dynamics Simulation Molecular Sequence Data Mutation neutralization Orthomyxoviridae Orthomyxoviridae - immunology Vaccination Vaccines
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