Rage mediated DAMP signaling in intestinal tumorigenesis
In the intestine, a large variety of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) can instigate innate immune responses, which have been shown to promote colorectal carcinogenesis. We have recently demonstrated an important role for the receptor for...
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| Veröffentlicht in: | Oncoimmunology 2012-10, Vol.1 (7), p.1165-1166 |
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| container_end_page | 1166 |
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| container_issue | 7 |
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| container_title | Oncoimmunology |
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| creator | Heijmans, Jarom Büller, Nikè V. J. A. Muncan, Vanesa van den Brink, Gijs R. |
| description | In the intestine, a large variety of pathogen-associated molecular patterns (PAMPs) and damage-associated molecular patterns (DAMPs) can instigate innate immune responses, which have been shown to promote colorectal carcinogenesis. We have recently demonstrated an important role for the receptor for advanced glycation end products (Rage) in intestinal adenoma formation. Rage is a receptor for DAMPs that are present in several proteins produced in intestinal adenomas. We found that Rage signaling upholds a pro-inflammatory milieu through a feed-forward loop that stimulates the production of its own ligands. |
| doi_str_mv | 10.4161/onci.20929 |
| format | Article |
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| subjects | ApcMin Author's View Binding Biology Bioscience Calcium Cancer Cell colon cancer Cycle innate immune system intestinal polyp Landes MyD88 Organogenesis Proteins Rage |
| title | Rage mediated DAMP signaling in intestinal tumorigenesis |
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