Lipid peroxidation and antioxidant supplementation in old age
An age-related rise in blood lipid peroxides measured by the thiobarbituric acid (TBA) method has been reported in several studies. Our study was designed to investigate whether this could be attributed to antioxidant deficiencies in aged individuals. We therefore measured the TB A-value of young an...
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| Veröffentlicht in: | Scandinavian journal of clinical and laboratory investigation 1990-02, Vol.50 (1), p.69-75 |
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| container_title | Scandinavian journal of clinical and laboratory investigation |
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| creator | Schafer, L. Thorling, E. B. |
| description | An age-related rise in blood lipid peroxides measured by the thiobarbituric acid (TBA) method has been reported in several studies. Our study was designed to investigate whether this could be attributed to antioxidant deficiencies in aged individuals. We therefore measured the TB A-value of young and old women and related this to vitamin E and selenium status and the fatty acid composition, triglyceride and cholesterol content of platelet-poor plasma. A significant difference (p |
| doi_str_mv | 10.1080/00365519009091567 |
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B.</creator><creatorcontrib>Schafer, L. ; Thorling, E. B.</creatorcontrib><description>An age-related rise in blood lipid peroxides measured by the thiobarbituric acid (TBA) method has been reported in several studies. Our study was designed to investigate whether this could be attributed to antioxidant deficiencies in aged individuals. We therefore measured the TB A-value of young and old women and related this to vitamin E and selenium status and the fatty acid composition, triglyceride and cholesterol content of platelet-poor plasma. A significant difference (p<0.001) between young and old women in the plasma TB A-value and the plasma lipid parameters was found. Old women had a lower selenium status than the young women (p<0.01), but their vitamin E status was fully adequate. Only the lipid parameters correlated significantly (p<0.001) with the TBA-value. In a 3-month placebo-controlled supplementation trial with vitamin E and selenium, the plasma TBA-value of the old women did not change. This study shows that the TBA-value of plasma is primarily determined by the fatty acid content and is not influenced by antioxidant supplementation in healthy individuals. The question of the sensitivity of the TB A-test is discussed.</description><identifier>ISSN: 0036-5513</identifier><identifier>EISSN: 1502-7686</identifier><identifier>DOI: 10.1080/00365519009091567</identifier><identifier>PMID: 2315645</identifier><identifier>CODEN: SJCLAY</identifier><language>eng</language><publisher>Oslo: Informa Healthcare</publisher><subject>Adult ; Aged ; Aging - blood ; Biological and medical sciences ; Cholesterol - blood ; fatty acid composition ; Fatty Acids - blood ; Fatty Acids, Unsaturated - blood ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Lipid Peroxides - blood ; Lipids. Glycolipids ; Metabolisms and neurohumoral controls ; selenium ; Selenium - administration & dosage ; Selenium - blood ; TBA-test ; Thiobarbiturates ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; vitamin E ; Vitamin E - administration & dosage ; Vitamin E - blood ; women</subject><ispartof>Scandinavian journal of clinical and laboratory investigation, 1990-02, Vol.50 (1), p.69-75</ispartof><rights>1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted 1990</rights><rights>1990 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c345t-d0da150b71ff892f332347b395a5200e6dbd71067b366ff7eb8d486c9efbe48d3</citedby><cites>FETCH-LOGICAL-c345t-d0da150b71ff892f332347b395a5200e6dbd71067b366ff7eb8d486c9efbe48d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.tandfonline.com/doi/pdf/10.1080/00365519009091567$$EPDF$$P50$$Ginformahealthcare$$H</linktopdf><linktohtml>$$Uhttps://www.tandfonline.com/doi/full/10.1080/00365519009091567$$EHTML$$P50$$Ginformahealthcare$$H</linktohtml><link.rule.ids>314,776,780,27903,27904,59623,59729,60412,60518,61197,61232,61378,61413</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=6805601$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/2315645$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Schafer, L.</creatorcontrib><creatorcontrib>Thorling, E. B.</creatorcontrib><title>Lipid peroxidation and antioxidant supplementation in old age</title><title>Scandinavian journal of clinical and laboratory investigation</title><addtitle>Scand J Clin Lab Invest</addtitle><description>An age-related rise in blood lipid peroxides measured by the thiobarbituric acid (TBA) method has been reported in several studies. Our study was designed to investigate whether this could be attributed to antioxidant deficiencies in aged individuals. We therefore measured the TB A-value of young and old women and related this to vitamin E and selenium status and the fatty acid composition, triglyceride and cholesterol content of platelet-poor plasma. A significant difference (p<0.001) between young and old women in the plasma TB A-value and the plasma lipid parameters was found. Old women had a lower selenium status than the young women (p<0.01), but their vitamin E status was fully adequate. Only the lipid parameters correlated significantly (p<0.001) with the TBA-value. In a 3-month placebo-controlled supplementation trial with vitamin E and selenium, the plasma TBA-value of the old women did not change. This study shows that the TBA-value of plasma is primarily determined by the fatty acid content and is not influenced by antioxidant supplementation in healthy individuals. The question of the sensitivity of the TB A-test is discussed.</description><subject>Adult</subject><subject>Aged</subject><subject>Aging - blood</subject><subject>Biological and medical sciences</subject><subject>Cholesterol - blood</subject><subject>fatty acid composition</subject><subject>Fatty Acids - blood</subject><subject>Fatty Acids, Unsaturated - blood</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Humans</subject><subject>Lipid Peroxides - blood</subject><subject>Lipids. Glycolipids</subject><subject>Metabolisms and neurohumoral controls</subject><subject>selenium</subject><subject>Selenium - administration & dosage</subject><subject>Selenium - blood</subject><subject>TBA-test</subject><subject>Thiobarbiturates</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>vitamin E</subject><subject>Vitamin E - administration & dosage</subject><subject>Vitamin E - blood</subject><subject>women</subject><issn>0036-5513</issn><issn>1502-7686</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1990</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kF9LwzAUxYMoc04_gA_CHsS36k3TpC3qgwz_wcAXfS5pk7iMNKlJi-7bm7E5EMGHkNx7fudycxA6xXCJoYArAMIoxSVACSWmLN9DY0whTXJWsH00XutJBMghOgphCbEmRTZCo5REOqNjdDvXnRbTTnr3pQXvtbNTbkU88bnu2H4ahq4zspW23-jaTp2JyLs8RgeKmyBPtvcEvT3cv86ekvnL4_Psbp40JKN9IkDwuFadY6WKMlWEpCTLa1JSTlMAyUQtcgwsthhTKpd1IbKCNaVUtcwKQSboYjO38-5jkKGvWh0aaQy30g2hykuWlxmkEcQbsPEuBC9V1Xndcr-qMFTryKo_kUXP2Xb4ULdS7BzbjKJ-vtV5aLhRnttGhx3GCqAMcMRuNpi2yvmWfzpvRNXzlXH-x0P-2-L6l30huekXDfeyWrrB2xjvP3_4BqComBg</recordid><startdate>199002</startdate><enddate>199002</enddate><creator>Schafer, L.</creator><creator>Thorling, E. B.</creator><general>Informa Healthcare</general><general>Taylor & Francis</general><general>Scandinavian University Press</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>199002</creationdate><title>Lipid peroxidation and antioxidant supplementation in old age</title><author>Schafer, L. ; Thorling, E. B.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c345t-d0da150b71ff892f332347b395a5200e6dbd71067b366ff7eb8d486c9efbe48d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1990</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aging - blood</topic><topic>Biological and medical sciences</topic><topic>Cholesterol - blood</topic><topic>fatty acid composition</topic><topic>Fatty Acids - blood</topic><topic>Fatty Acids, Unsaturated - blood</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Humans</topic><topic>Lipid Peroxides - blood</topic><topic>Lipids. Glycolipids</topic><topic>Metabolisms and neurohumoral controls</topic><topic>selenium</topic><topic>Selenium - administration & dosage</topic><topic>Selenium - blood</topic><topic>TBA-test</topic><topic>Thiobarbiturates</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>vitamin E</topic><topic>Vitamin E - administration & dosage</topic><topic>Vitamin E - blood</topic><topic>women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Schafer, L.</creatorcontrib><creatorcontrib>Thorling, E. B.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of clinical and laboratory investigation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Schafer, L.</au><au>Thorling, E. B.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Lipid peroxidation and antioxidant supplementation in old age</atitle><jtitle>Scandinavian journal of clinical and laboratory investigation</jtitle><addtitle>Scand J Clin Lab Invest</addtitle><date>1990-02</date><risdate>1990</risdate><volume>50</volume><issue>1</issue><spage>69</spage><epage>75</epage><pages>69-75</pages><issn>0036-5513</issn><eissn>1502-7686</eissn><coden>SJCLAY</coden><abstract>An age-related rise in blood lipid peroxides measured by the thiobarbituric acid (TBA) method has been reported in several studies. Our study was designed to investigate whether this could be attributed to antioxidant deficiencies in aged individuals. We therefore measured the TB A-value of young and old women and related this to vitamin E and selenium status and the fatty acid composition, triglyceride and cholesterol content of platelet-poor plasma. A significant difference (p<0.001) between young and old women in the plasma TB A-value and the plasma lipid parameters was found. Old women had a lower selenium status than the young women (p<0.01), but their vitamin E status was fully adequate. Only the lipid parameters correlated significantly (p<0.001) with the TBA-value. In a 3-month placebo-controlled supplementation trial with vitamin E and selenium, the plasma TBA-value of the old women did not change. This study shows that the TBA-value of plasma is primarily determined by the fatty acid content and is not influenced by antioxidant supplementation in healthy individuals. The question of the sensitivity of the TB A-test is discussed.</abstract><cop>Oslo</cop><pub>Informa Healthcare</pub><pmid>2315645</pmid><doi>10.1080/00365519009091567</doi><tpages>7</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-5513 |
| ispartof | Scandinavian journal of clinical and laboratory investigation, 1990-02, Vol.50 (1), p.69-75 |
| issn | 0036-5513 1502-7686 |
| language | eng |
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| source | MEDLINE; Taylor & Francis Medical Library - CRKN; Taylor & Francis Journals Complete |
| subjects | Adult Aged Aging - blood Biological and medical sciences Cholesterol - blood fatty acid composition Fatty Acids - blood Fatty Acids, Unsaturated - blood Female Fundamental and applied biological sciences. Psychology Humans Lipid Peroxides - blood Lipids. Glycolipids Metabolisms and neurohumoral controls selenium Selenium - administration & dosage Selenium - blood TBA-test Thiobarbiturates Vertebrates: anatomy and physiology, studies on body, several organs or systems vitamin E Vitamin E - administration & dosage Vitamin E - blood women |
| title | Lipid peroxidation and antioxidant supplementation in old age |
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