Kras(G12D) and Nkx2-1 haploinsufficiency induce mucinous adenocarcinoma of the lung

Mucinous adenocarcinoma of the lung is a subtype of highly invasive pulmonary tumors and is associated with decreased or absent expression of the transcription factor NK2 homeobox 1 (NKX2-1; also known as TTF-1). Here, we show that haploinsufficiency of Nkx2-1 in combination with oncogenic Kras(G12D...

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Veröffentlicht in:	The Journal of clinical investigation 2012-12, Vol.122 (12), p.4388
Hauptverfasser:	Maeda, Yutaka, Tsuchiya, Tomoshi, Hao, Haiping, Tompkins, David H, Xu, Yan, Mucenski, Michael L, Du, Lingling, Keiser, Angela R, Fukazawa, Takuya, Naomoto, Yoshio, Nagayasu, Takeshi, Whitsett, Jeffrey A
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma, Mucinous - genetics Amino Acid Substitution Animals Base Sequence Binding Sites Cell Line, Tumor Cell Transformation, Neoplastic - genetics Consensus Sequence Gene Expression Regulation, Neoplastic Goblet Cells - metabolism Goblet Cells - pathology Haploinsufficiency Hepatocyte Nuclear Factor 3-gamma - metabolism Humans Lung Neoplasms - chemically induced Lung Neoplasms - genetics Lung Neoplasms - pathology Mice Mice, Transgenic Neoplasms, Experimental - chemically induced Neoplasms, Experimental - genetics Neoplasms, Experimental - pathology Nuclear Proteins - deficiency Nuclear Proteins - genetics Oligonucleotide Array Sequence Analysis Promoter Regions, Genetic Proto-Oncogene Proteins c-ets - metabolism Proto-Oncogene Proteins p21(ras) - genetics Pulmonary Surfactant-Associated Protein A - genetics Receptor, Epidermal Growth Factor - genetics Thyroid Nuclear Factor 1 Transcription Factor AP-1 - metabolism Transcription Factors - deficiency Transcription Factors - genetics Transcriptome Tumor Burden Urethane
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