Dosimetric investigation of accelerated partial breast irradiation (APBI) using CyberKnife
Purpose: To investigate the dosimetric feasibility of accelerated partial breast irradiation (APBI) using CyberKnife. Methods: Fourteen previously treated patients with early-stage breast cancer were selected for a retrospective study. Six of these patients had been treated to 38.5 Gy in 10 fraction...
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| creator | Xu, Qianyi Chen, Yan Grimm, Jimm Fan, Jiajin An, Lili Xue, Jinyu Pahlajani, Niraj LaCouture, Tamara |
| description | Purpose:
To investigate the dosimetric feasibility of accelerated partial breast irradiation (APBI) using CyberKnife.
Methods:
Fourteen previously treated patients with early-stage breast cancer were selected for a retrospective study. Six of these patients had been treated to 38.5 Gy in 10 fractions in a phase III accelerated partial breast trial and the rest of the patients were treated to 50.4 Gy in 28 fractions. In this planning study, the guidelines in the protocol for the phase III partial breast trial were followed for organ delineation and CyberKnife planning. The achievable dosimetric parameters from all CyberKnife plans were compared to Intensity-modulated radiation therapy (IMRT) and 3D-CRT methods. The reproducibility of the dose delivery with and without respiratory motion was assessed through delivering a patient plan to a breast phantom. Different dose calculation algorithms were also compared between ray tracing and Monte Carlo.
Results:
For all the patients in the study, the dosimetric parameters met the guidelines from the NSABP B39/RTOG 0413 protocol strictly. The mean PTV volume covered by 100% of the prescription dose was 95.7 ± 0.7% (94.7%–97.1%). The mean maximal dose was 104 ± 2% of the prescription dose. The mean V50% and mean V100% to the ipsilateral normal breast were 23.1 ± 11.6% and 9.0 ± 5.8%, respectively. The conformity index of all plans was 1.14 ± 0.04. The maximum dose to the contralateral breast varied from 1.3 cGy to 111 cGy. The mean V5% and mean V30% to the contralateral and ipsilateral lungs were 1.0 ± 1.6% and 1.3 ± 1.2%, respectively. In our study, the mean V5% to the heart was 0.2 ± 0.5% for right-sided tumors and 9.4 ± 10.1% for left-sided tumors. Compared with IMRT and 3D-CRT planning, the PTV coverage from CyberKnife planning was the highest, and the ratio of V20% to V100% of the breast from CyberKnife planning was the smallest. The heart and lung doses were similar in all the techniques except that the V5% for the lung and heart in CyberKnife planning was slightly higher.
Conclusions:
The dosimetric feasibility of APBI using CyberKnife was investigated in this retrospective study. All the dosimetric parameters strictly met the guidelines from the NSABP B39/RTOG 0413 protocol. With advanced real-time tracking capability, CyberKnife should provide better target coverage and spare nearby critical organs for APBI treatment. |
| doi_str_mv | 10.1118/1.4757616 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_23127056</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1141540124</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4596-8a9a360718ffc3dfcaec4673ed9273b324bb8d78d476a71ad96eb4ec83f9ecbb3</originalsourceid><addsrcrecordid>eNp90MtOwzAQBVALgaAUFvwAyhKQUuzYsZMllKcA0QVs2ER-jJFRXtgpqH9PIKVCQrCazZmrmYvQHsETQkh2TCZMpIITvoZGCRM0ZgnO19EI45zFCcPpFtoO4QVjzGmKN9FWQkkicMpH6OmsCa6CzjsdufoNQueeZeeaOmpsJLWGErzswESt9J2TZaQ8yNBFzntp3CAPTman14fRPLj6OZouFPib2lnYQRtWlgF2l3OMHi_OH6ZX8e395fX05DbWLM15nMlcUo4FyazV1FgtQTMuKJg8EVTRhCmVGZEZJrgURJqcg2KgM2pz0ErRMToYclvfvM77D4rKhf7wUtbQzENBCCMpwyRhPT0cqPZNCB5s0XpXSb8oCC4-qyxIsayyt_vL2LmqwKzkd3c9iAfw7kpY_J1U3M2WgUeDD9p1X82tdt4a_8O3xv6Hf5_6AWkEmJg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1141540124</pqid></control><display><type>article</type><title>Dosimetric investigation of accelerated partial breast irradiation (APBI) using CyberKnife</title><source>Wiley Online Library - AutoHoldings Journals</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Xu, Qianyi ; Chen, Yan ; Grimm, Jimm ; Fan, Jiajin ; An, Lili ; Xue, Jinyu ; Pahlajani, Niraj ; LaCouture, Tamara</creator><creatorcontrib>Xu, Qianyi ; Chen, Yan ; Grimm, Jimm ; Fan, Jiajin ; An, Lili ; Xue, Jinyu ; Pahlajani, Niraj ; LaCouture, Tamara</creatorcontrib><description>Purpose:
To investigate the dosimetric feasibility of accelerated partial breast irradiation (APBI) using CyberKnife.
Methods:
Fourteen previously treated patients with early-stage breast cancer were selected for a retrospective study. Six of these patients had been treated to 38.5 Gy in 10 fractions in a phase III accelerated partial breast trial and the rest of the patients were treated to 50.4 Gy in 28 fractions. In this planning study, the guidelines in the protocol for the phase III partial breast trial were followed for organ delineation and CyberKnife planning. The achievable dosimetric parameters from all CyberKnife plans were compared to Intensity-modulated radiation therapy (IMRT) and 3D-CRT methods. The reproducibility of the dose delivery with and without respiratory motion was assessed through delivering a patient plan to a breast phantom. Different dose calculation algorithms were also compared between ray tracing and Monte Carlo.
Results:
For all the patients in the study, the dosimetric parameters met the guidelines from the NSABP B39/RTOG 0413 protocol strictly. The mean PTV volume covered by 100% of the prescription dose was 95.7 ± 0.7% (94.7%–97.1%). The mean maximal dose was 104 ± 2% of the prescription dose. The mean V50% and mean V100% to the ipsilateral normal breast were 23.1 ± 11.6% and 9.0 ± 5.8%, respectively. The conformity index of all plans was 1.14 ± 0.04. The maximum dose to the contralateral breast varied from 1.3 cGy to 111 cGy. The mean V5% and mean V30% to the contralateral and ipsilateral lungs were 1.0 ± 1.6% and 1.3 ± 1.2%, respectively. In our study, the mean V5% to the heart was 0.2 ± 0.5% for right-sided tumors and 9.4 ± 10.1% for left-sided tumors. Compared with IMRT and 3D-CRT planning, the PTV coverage from CyberKnife planning was the highest, and the ratio of V20% to V100% of the breast from CyberKnife planning was the smallest. The heart and lung doses were similar in all the techniques except that the V5% for the lung and heart in CyberKnife planning was slightly higher.
Conclusions:
The dosimetric feasibility of APBI using CyberKnife was investigated in this retrospective study. All the dosimetric parameters strictly met the guidelines from the NSABP B39/RTOG 0413 protocol. With advanced real-time tracking capability, CyberKnife should provide better target coverage and spare nearby critical organs for APBI treatment.</description><identifier>ISSN: 0094-2405</identifier><identifier>EISSN: 2473-4209</identifier><identifier>DOI: 10.1118/1.4757616</identifier><identifier>PMID: 23127056</identifier><identifier>CODEN: MPHYA6</identifier><language>eng</language><publisher>United States: American Association of Physicists in Medicine</publisher><subject>APBI ; Applications ; Breast - surgery ; Breast Neoplasms - surgery ; Cancer ; Cardiac dynamics ; cardiology ; CyberKnife ; Dose‐volume analysis ; dosimetry ; Female ; Heart ; Humans ; Intensity modulated radiation therapy ; lung ; Lungs ; Mastectomy, Segmental - methods ; Monte Carlo Method ; Monte Carlo methods ; Monte Carlo simulations ; phantoms ; Phantoms, Imaging ; planning ; radiation therapy ; Radiation treatment ; Radiometry ; Radiosurgery - methods ; Real time information delivery ; Retrospective Studies ; Therapeutics ; tumours</subject><ispartof>Medical physics (Lancaster), 2012-11, Vol.39 (11), p.6621-6628</ispartof><rights>American Association of Physicists in Medicine</rights><rights>2012 American Association of Physicists in Medicine</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4596-8a9a360718ffc3dfcaec4673ed9273b324bb8d78d476a71ad96eb4ec83f9ecbb3</citedby><cites>FETCH-LOGICAL-c4596-8a9a360718ffc3dfcaec4673ed9273b324bb8d78d476a71ad96eb4ec83f9ecbb3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1118%2F1.4757616$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1118%2F1.4757616$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23127056$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Qianyi</creatorcontrib><creatorcontrib>Chen, Yan</creatorcontrib><creatorcontrib>Grimm, Jimm</creatorcontrib><creatorcontrib>Fan, Jiajin</creatorcontrib><creatorcontrib>An, Lili</creatorcontrib><creatorcontrib>Xue, Jinyu</creatorcontrib><creatorcontrib>Pahlajani, Niraj</creatorcontrib><creatorcontrib>LaCouture, Tamara</creatorcontrib><title>Dosimetric investigation of accelerated partial breast irradiation (APBI) using CyberKnife</title><title>Medical physics (Lancaster)</title><addtitle>Med Phys</addtitle><description>Purpose:
To investigate the dosimetric feasibility of accelerated partial breast irradiation (APBI) using CyberKnife.
Methods:
Fourteen previously treated patients with early-stage breast cancer were selected for a retrospective study. Six of these patients had been treated to 38.5 Gy in 10 fractions in a phase III accelerated partial breast trial and the rest of the patients were treated to 50.4 Gy in 28 fractions. In this planning study, the guidelines in the protocol for the phase III partial breast trial were followed for organ delineation and CyberKnife planning. The achievable dosimetric parameters from all CyberKnife plans were compared to Intensity-modulated radiation therapy (IMRT) and 3D-CRT methods. The reproducibility of the dose delivery with and without respiratory motion was assessed through delivering a patient plan to a breast phantom. Different dose calculation algorithms were also compared between ray tracing and Monte Carlo.
Results:
For all the patients in the study, the dosimetric parameters met the guidelines from the NSABP B39/RTOG 0413 protocol strictly. The mean PTV volume covered by 100% of the prescription dose was 95.7 ± 0.7% (94.7%–97.1%). The mean maximal dose was 104 ± 2% of the prescription dose. The mean V50% and mean V100% to the ipsilateral normal breast were 23.1 ± 11.6% and 9.0 ± 5.8%, respectively. The conformity index of all plans was 1.14 ± 0.04. The maximum dose to the contralateral breast varied from 1.3 cGy to 111 cGy. The mean V5% and mean V30% to the contralateral and ipsilateral lungs were 1.0 ± 1.6% and 1.3 ± 1.2%, respectively. In our study, the mean V5% to the heart was 0.2 ± 0.5% for right-sided tumors and 9.4 ± 10.1% for left-sided tumors. Compared with IMRT and 3D-CRT planning, the PTV coverage from CyberKnife planning was the highest, and the ratio of V20% to V100% of the breast from CyberKnife planning was the smallest. The heart and lung doses were similar in all the techniques except that the V5% for the lung and heart in CyberKnife planning was slightly higher.
Conclusions:
The dosimetric feasibility of APBI using CyberKnife was investigated in this retrospective study. All the dosimetric parameters strictly met the guidelines from the NSABP B39/RTOG 0413 protocol. With advanced real-time tracking capability, CyberKnife should provide better target coverage and spare nearby critical organs for APBI treatment.</description><subject>APBI</subject><subject>Applications</subject><subject>Breast - surgery</subject><subject>Breast Neoplasms - surgery</subject><subject>Cancer</subject><subject>Cardiac dynamics</subject><subject>cardiology</subject><subject>CyberKnife</subject><subject>Dose‐volume analysis</subject><subject>dosimetry</subject><subject>Female</subject><subject>Heart</subject><subject>Humans</subject><subject>Intensity modulated radiation therapy</subject><subject>lung</subject><subject>Lungs</subject><subject>Mastectomy, Segmental - methods</subject><subject>Monte Carlo Method</subject><subject>Monte Carlo methods</subject><subject>Monte Carlo simulations</subject><subject>phantoms</subject><subject>Phantoms, Imaging</subject><subject>planning</subject><subject>radiation therapy</subject><subject>Radiation treatment</subject><subject>Radiometry</subject><subject>Radiosurgery - methods</subject><subject>Real time information delivery</subject><subject>Retrospective Studies</subject><subject>Therapeutics</subject><subject>tumours</subject><issn>0094-2405</issn><issn>2473-4209</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp90MtOwzAQBVALgaAUFvwAyhKQUuzYsZMllKcA0QVs2ER-jJFRXtgpqH9PIKVCQrCazZmrmYvQHsETQkh2TCZMpIITvoZGCRM0ZgnO19EI45zFCcPpFtoO4QVjzGmKN9FWQkkicMpH6OmsCa6CzjsdufoNQueeZeeaOmpsJLWGErzswESt9J2TZaQ8yNBFzntp3CAPTman14fRPLj6OZouFPib2lnYQRtWlgF2l3OMHi_OH6ZX8e395fX05DbWLM15nMlcUo4FyazV1FgtQTMuKJg8EVTRhCmVGZEZJrgURJqcg2KgM2pz0ErRMToYclvfvM77D4rKhf7wUtbQzENBCCMpwyRhPT0cqPZNCB5s0XpXSb8oCC4-qyxIsayyt_vL2LmqwKzkd3c9iAfw7kpY_J1U3M2WgUeDD9p1X82tdt4a_8O3xv6Hf5_6AWkEmJg</recordid><startdate>201211</startdate><enddate>201211</enddate><creator>Xu, Qianyi</creator><creator>Chen, Yan</creator><creator>Grimm, Jimm</creator><creator>Fan, Jiajin</creator><creator>An, Lili</creator><creator>Xue, Jinyu</creator><creator>Pahlajani, Niraj</creator><creator>LaCouture, Tamara</creator><general>American Association of Physicists in Medicine</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201211</creationdate><title>Dosimetric investigation of accelerated partial breast irradiation (APBI) using CyberKnife</title><author>Xu, Qianyi ; Chen, Yan ; Grimm, Jimm ; Fan, Jiajin ; An, Lili ; Xue, Jinyu ; Pahlajani, Niraj ; LaCouture, Tamara</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4596-8a9a360718ffc3dfcaec4673ed9273b324bb8d78d476a71ad96eb4ec83f9ecbb3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>APBI</topic><topic>Applications</topic><topic>Breast - surgery</topic><topic>Breast Neoplasms - surgery</topic><topic>Cancer</topic><topic>Cardiac dynamics</topic><topic>cardiology</topic><topic>CyberKnife</topic><topic>Dose‐volume analysis</topic><topic>dosimetry</topic><topic>Female</topic><topic>Heart</topic><topic>Humans</topic><topic>Intensity modulated radiation therapy</topic><topic>lung</topic><topic>Lungs</topic><topic>Mastectomy, Segmental - methods</topic><topic>Monte Carlo Method</topic><topic>Monte Carlo methods</topic><topic>Monte Carlo simulations</topic><topic>phantoms</topic><topic>Phantoms, Imaging</topic><topic>planning</topic><topic>radiation therapy</topic><topic>Radiation treatment</topic><topic>Radiometry</topic><topic>Radiosurgery - methods</topic><topic>Real time information delivery</topic><topic>Retrospective Studies</topic><topic>Therapeutics</topic><topic>tumours</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Qianyi</creatorcontrib><creatorcontrib>Chen, Yan</creatorcontrib><creatorcontrib>Grimm, Jimm</creatorcontrib><creatorcontrib>Fan, Jiajin</creatorcontrib><creatorcontrib>An, Lili</creatorcontrib><creatorcontrib>Xue, Jinyu</creatorcontrib><creatorcontrib>Pahlajani, Niraj</creatorcontrib><creatorcontrib>LaCouture, Tamara</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Medical physics (Lancaster)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Qianyi</au><au>Chen, Yan</au><au>Grimm, Jimm</au><au>Fan, Jiajin</au><au>An, Lili</au><au>Xue, Jinyu</au><au>Pahlajani, Niraj</au><au>LaCouture, Tamara</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dosimetric investigation of accelerated partial breast irradiation (APBI) using CyberKnife</atitle><jtitle>Medical physics (Lancaster)</jtitle><addtitle>Med Phys</addtitle><date>2012-11</date><risdate>2012</risdate><volume>39</volume><issue>11</issue><spage>6621</spage><epage>6628</epage><pages>6621-6628</pages><issn>0094-2405</issn><eissn>2473-4209</eissn><coden>MPHYA6</coden><abstract>Purpose:
To investigate the dosimetric feasibility of accelerated partial breast irradiation (APBI) using CyberKnife.
Methods:
Fourteen previously treated patients with early-stage breast cancer were selected for a retrospective study. Six of these patients had been treated to 38.5 Gy in 10 fractions in a phase III accelerated partial breast trial and the rest of the patients were treated to 50.4 Gy in 28 fractions. In this planning study, the guidelines in the protocol for the phase III partial breast trial were followed for organ delineation and CyberKnife planning. The achievable dosimetric parameters from all CyberKnife plans were compared to Intensity-modulated radiation therapy (IMRT) and 3D-CRT methods. The reproducibility of the dose delivery with and without respiratory motion was assessed through delivering a patient plan to a breast phantom. Different dose calculation algorithms were also compared between ray tracing and Monte Carlo.
Results:
For all the patients in the study, the dosimetric parameters met the guidelines from the NSABP B39/RTOG 0413 protocol strictly. The mean PTV volume covered by 100% of the prescription dose was 95.7 ± 0.7% (94.7%–97.1%). The mean maximal dose was 104 ± 2% of the prescription dose. The mean V50% and mean V100% to the ipsilateral normal breast were 23.1 ± 11.6% and 9.0 ± 5.8%, respectively. The conformity index of all plans was 1.14 ± 0.04. The maximum dose to the contralateral breast varied from 1.3 cGy to 111 cGy. The mean V5% and mean V30% to the contralateral and ipsilateral lungs were 1.0 ± 1.6% and 1.3 ± 1.2%, respectively. In our study, the mean V5% to the heart was 0.2 ± 0.5% for right-sided tumors and 9.4 ± 10.1% for left-sided tumors. Compared with IMRT and 3D-CRT planning, the PTV coverage from CyberKnife planning was the highest, and the ratio of V20% to V100% of the breast from CyberKnife planning was the smallest. The heart and lung doses were similar in all the techniques except that the V5% for the lung and heart in CyberKnife planning was slightly higher.
Conclusions:
The dosimetric feasibility of APBI using CyberKnife was investigated in this retrospective study. All the dosimetric parameters strictly met the guidelines from the NSABP B39/RTOG 0413 protocol. With advanced real-time tracking capability, CyberKnife should provide better target coverage and spare nearby critical organs for APBI treatment.</abstract><cop>United States</cop><pub>American Association of Physicists in Medicine</pub><pmid>23127056</pmid><doi>10.1118/1.4757616</doi><tpages>8</tpages></addata></record> |
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| source | Wiley Online Library - AutoHoldings Journals; MEDLINE; Alma/SFX Local Collection |
| subjects | APBI Applications Breast - surgery Breast Neoplasms - surgery Cancer Cardiac dynamics cardiology CyberKnife Dose‐volume analysis dosimetry Female Heart Humans Intensity modulated radiation therapy lung Lungs Mastectomy, Segmental - methods Monte Carlo Method Monte Carlo methods Monte Carlo simulations phantoms Phantoms, Imaging planning radiation therapy Radiation treatment Radiometry Radiosurgery - methods Real time information delivery Retrospective Studies Therapeutics tumours |
| title | Dosimetric investigation of accelerated partial breast irradiation (APBI) using CyberKnife |
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