Novel Apidaecin 1b Analogs with Superior Serum Stabilities for Treatment of Infections by Gram-Negative Pathogens

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Veröffentlicht in:	Antimicrobial Agents and Chemotherapy 2013-01, Vol.57 (1), p.402-409
Hauptverfasser:	BERTHOLD, Nicole, CZIHAL, Patricia, FRITSCHE, Stefanie, SAUER, Ute, SCHIFFER, Guido, KNAPPE, Daniel, ALBER, Gottfried, HOFFMANN, Ralf
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Sequence Amino Acid Substitution Animals Anti-Bacterial Agents - blood Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antimicrobial Cationic Peptides Antimicrobial Cationic Peptides - blood Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - pharmacology Arginine - chemistry Arginine - metabolism Biological and medical sciences Biosynthesis Cell Line, Tumor Cell Survival - drug effects Chemistry Chemistry Biosynthesis Dendritic Cells - drug effects Erythrocytes - drug effects Escherichia coli Escherichia coli - drug effects Escherichia coli - growth & development Escherichia coli Proteins Escherichia coli Proteins - antagonists & inhibitors Escherichia coli Proteins - metabolism Half-Life Homoarginine - chemistry Homoarginine - metabolism HSP70 Heat-Shock Proteins HSP70 Heat-Shock Proteins - antagonists & inhibitors HSP70 Heat-Shock Proteins - metabolism Humans Medical sciences Mice Microbial Sensitivity Tests Molecular Sequence Data Ornithine - chemistry Ornithine - metabolism Pharmacology. Drug treatments Protein Stability Structure-Activity Relationship
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