The toxin-antitoxin system tisB-istR1: Expression, regulation, and biological role in persister phenotypes
Chromosomally encoded toxin-antitoxin (TA) systems are abundantly present in bacteria and archaea. They have become a hot topic in recent years, because-after many frustrating years of searching for biological functions-some are now known to play roles in persister formation. Persister cells represe...
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| Veröffentlicht in: | RNA biology 2012-12, Vol.9 (12), p.1513-1519 |
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| creator | Wagner, E. Gerhart H. Unoson, Cecilia |
| description | Chromosomally encoded toxin-antitoxin (TA) systems are abundantly present in bacteria and archaea. They have become a hot topic in recent years, because-after many frustrating years of searching for biological functions-some are now known to play roles in persister formation. Persister cells represent a subset of a bacterial population that enters a dormant state and thus becomes refractory to the action of antibiotics. TA modules come in several different flavors, regarding the nature of their gene products, their molecular mechanisms of regulation, their cellular targets, and probably their role in physiology. This review will primarily focus on the SOS-associated tisB/istR1 system in Escherichia coli and discuss its nuts and bolts as well as its effect in promoting a subpopulation phenotype that likely benefits long-term survival of a stressed population. |
| doi_str_mv | 10.4161/rna.22578 |
| format | Article |
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Gerhart H.</creatorcontrib><creatorcontrib>Unoson, Cecilia</creatorcontrib><title>The toxin-antitoxin system tisB-istR1: Expression, regulation, and biological role in persister phenotypes</title><title>RNA biology</title><addtitle>RNA Biol</addtitle><description>Chromosomally encoded toxin-antitoxin (TA) systems are abundantly present in bacteria and archaea. They have become a hot topic in recent years, because-after many frustrating years of searching for biological functions-some are now known to play roles in persister formation. Persister cells represent a subset of a bacterial population that enters a dormant state and thus becomes refractory to the action of antibiotics. TA modules come in several different flavors, regarding the nature of their gene products, their molecular mechanisms of regulation, their cellular targets, and probably their role in physiology. 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Gerhart H. ; Unoson, Cecilia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c327t-172ab0b90d98497f876ea2860a28eef696aceda363a5df1d4e90dcf15b5b38133</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>antisense RNA</topic><topic>Antitoxins - chemistry</topic><topic>Antitoxins - genetics</topic><topic>Bacterial Toxins - chemistry</topic><topic>Bacterial Toxins - genetics</topic><topic>Cell Membrane - chemistry</topic><topic>Cell Membrane - genetics</topic><topic>Chromosomes, Bacterial - chemistry</topic><topic>Chromosomes, Bacterial - genetics</topic><topic>Escherichia coli - chemistry</topic><topic>Escherichia coli - genetics</topic><topic>Escherichia coli Proteins - chemistry</topic><topic>Escherichia coli Proteins - genetics</topic><topic>Gene Expression Regulation, Bacterial</topic><topic>Hydrophobic and Hydrophilic Interactions</topic><topic>persisters</topic><topic>Phenotype</topic><topic>Ribosomes - chemistry</topic><topic>Ribosomes - genetics</topic><topic>RNA Stability</topic><topic>RNA, Antisense - chemistry</topic><topic>RNA, Antisense - genetics</topic><topic>RNA, Bacterial - chemistry</topic><topic>RNA, Bacterial - genetics</topic><topic>RNA, Messenger - chemistry</topic><topic>RNA, Messenger - genetics</topic><topic>SOS Response (Genetics)</topic><topic>sRNA</topic><topic>Toxin-antitoxin system</topic><topic>translational control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wagner, E. 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Gerhart H.</au><au>Unoson, Cecilia</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The toxin-antitoxin system tisB-istR1: Expression, regulation, and biological role in persister phenotypes</atitle><jtitle>RNA biology</jtitle><addtitle>RNA Biol</addtitle><date>2012-12-01</date><risdate>2012</risdate><volume>9</volume><issue>12</issue><spage>1513</spage><epage>1519</epage><pages>1513-1519</pages><issn>1547-6286</issn><issn>1555-8584</issn><eissn>1555-8584</eissn><abstract>Chromosomally encoded toxin-antitoxin (TA) systems are abundantly present in bacteria and archaea. They have become a hot topic in recent years, because-after many frustrating years of searching for biological functions-some are now known to play roles in persister formation. Persister cells represent a subset of a bacterial population that enters a dormant state and thus becomes refractory to the action of antibiotics. TA modules come in several different flavors, regarding the nature of their gene products, their molecular mechanisms of regulation, their cellular targets, and probably their role in physiology. This review will primarily focus on the SOS-associated tisB/istR1 system in Escherichia coli and discuss its nuts and bolts as well as its effect in promoting a subpopulation phenotype that likely benefits long-term survival of a stressed population.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>23093802</pmid><doi>10.4161/rna.22578</doi><tpages>7</tpages></addata></record> |
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| ispartof | RNA biology, 2012-12, Vol.9 (12), p.1513-1519 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; PubMed Central |
| subjects | antisense RNA Antitoxins - chemistry Antitoxins - genetics Bacterial Toxins - chemistry Bacterial Toxins - genetics Cell Membrane - chemistry Cell Membrane - genetics Chromosomes, Bacterial - chemistry Chromosomes, Bacterial - genetics Escherichia coli - chemistry Escherichia coli - genetics Escherichia coli Proteins - chemistry Escherichia coli Proteins - genetics Gene Expression Regulation, Bacterial Hydrophobic and Hydrophilic Interactions persisters Phenotype Ribosomes - chemistry Ribosomes - genetics RNA Stability RNA, Antisense - chemistry RNA, Antisense - genetics RNA, Bacterial - chemistry RNA, Bacterial - genetics RNA, Messenger - chemistry RNA, Messenger - genetics SOS Response (Genetics) sRNA Toxin-antitoxin system translational control |
| title | The toxin-antitoxin system tisB-istR1: Expression, regulation, and biological role in persister phenotypes |
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