The impact of total antioxidant capacity on pulmonary function in asthma patients
BACKGROUND: Oxidative stress, mediated by an imbalance between oxidants and antioxidants, contributes significantly to the pathogenesis of asthma.OBJECTIVE: To evaluate the impact of serum total antioxidant capacity (TAC) on the pulmonary function of Korean asthma patients.METHOD: A total of 104 adu...
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| Veröffentlicht in: | The international journal of tuberculosis and lung disease 2012-11, Vol.16 (11), p.1544-1550 |
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| container_title | The international journal of tuberculosis and lung disease |
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| creator | Yoon, S. Y. Kim, T-B. Baek, S. Kim, S. Kwon, H-S. Lee, Y. S. Lee, T. Jang, A-S. Chang, Y-S. Cho, S-H. Choi, B. W. Park, J. W. Nham, D-H. Yoon, H-J. Cho, Y-J. Park, C-S. Moon, H-B. Cho, Y. S. COREA Study Group |
| description | BACKGROUND: Oxidative stress, mediated by an imbalance between oxidants and antioxidants, contributes significantly to the pathogenesis of asthma.OBJECTIVE: To evaluate the impact of serum total antioxidant capacity (TAC) on the pulmonary function of Korean asthma patients.METHOD:
A total of 104 adult asthma patients enrolled from the COREA (Cohort for Reality and Evolution of Adult Asthma in Korea) programme participated in the study. Baseline clinical parameters at enrolment, and the results of pulmonary function tests at baseline and 1 and 2 years after enrolment
were collected. TAC at baseline was measured using a Trolox-equivalent antioxidant capacity assay. Patients were divided into two groups based on TAC levels, and various clinical parameters were compared.RESULT: Serum TAC levels correlated with forced expiratory volume in 1 second (FEV1)
at baseline (r = 0.22, P = 0.03). The group with higher baseline TAC levels maintained greater mean FEV1 both 1 and 2 years after enrolment, even after adjusting for sex, age, height, weight, body mass index and smoking status.CONCLUSION: These results suggest
an important link between serum TAC levels and pulmonary function, indicating that higher TAC levels may be a biomarker for favourable prognosis in asthma patients. |
| doi_str_mv | 10.5588/ijtld.12.0842 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_23044449</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><ingid>iuatld/ijtld/2012/00000016/00000011/art00022</ingid><sourcerecordid>1095631879</sourcerecordid><originalsourceid>FETCH-LOGICAL-c459t-c3ce882769e5fbe287c55347c73e7a33d628137b5f374d19f58b13b135d8191a3</originalsourceid><addsrcrecordid>eNp1kU1v1DAQhiMEoqVw5Ip8QeKSxWPHsX1E5VOqVLUqZ2vWsVuvEifETkX59TjdXTh1ZGlG8uN3xu9U1VugGyGU-hh2ue82wDZUNexZdQoKRC01o89LTZmsuQR9Ur1KaUcpAwD5sjphnDYl9Gl1dXPnSBgmtJmMnuQxY08w5jD-Dl3JxGK5C_mBjJFMSz-MEecH4pdoCxNJiARTvhuQTJiDizm9rl547JN7c8hn1c-vX27Ov9cXl99-nH-6qG0jdK4tt04pJlvthN86pqQVgjfSSu4kct61TAGXW-G5bDrQXqgt8HJEp0AD8rPqw153msdfi0vZDCFZ1_cY3bgkA1SLloOSuqD1HrXzmNLsvJnmMJR_FMisLppHFw0ws7pY-HcH6WU7uO4ffbStAO8PACaLvZ8x2pD-c22jW2hV4T7vuRBvizdoduMyx-KKCQuuHfd9GV07Pwa0xwIMzrkUbJ3n-ikZe1Rad72u2txDG8tjVpZNFRMGGsFN5zwufTYZZ3P7x6Qi-heyF6w7</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1095631879</pqid></control><display><type>article</type><title>The impact of total antioxidant capacity on pulmonary function in asthma patients</title><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Yoon, S. Y. ; Kim, T-B. ; Baek, S. ; Kim, S. ; Kwon, H-S. ; Lee, Y. S. ; Lee, T. ; Jang, A-S. ; Chang, Y-S. ; Cho, S-H. ; Choi, B. W. ; Park, J. W. ; Nham, D-H. ; Yoon, H-J. ; Cho, Y-J. ; Park, C-S. ; Moon, H-B. ; Cho, Y. S. ; COREA Study Group</creator><creatorcontrib>Yoon, S. Y. ; Kim, T-B. ; Baek, S. ; Kim, S. ; Kwon, H-S. ; Lee, Y. S. ; Lee, T. ; Jang, A-S. ; Chang, Y-S. ; Cho, S-H. ; Choi, B. W. ; Park, J. W. ; Nham, D-H. ; Yoon, H-J. ; Cho, Y-J. ; Park, C-S. ; Moon, H-B. ; Cho, Y. S. ; COREA Study Group ; COREA Study Group</creatorcontrib><description>BACKGROUND: Oxidative stress, mediated by an imbalance between oxidants and antioxidants, contributes significantly to the pathogenesis of asthma.OBJECTIVE: To evaluate the impact of serum total antioxidant capacity (TAC) on the pulmonary function of Korean asthma patients.METHOD:
A total of 104 adult asthma patients enrolled from the COREA (Cohort for Reality and Evolution of Adult Asthma in Korea) programme participated in the study. Baseline clinical parameters at enrolment, and the results of pulmonary function tests at baseline and 1 and 2 years after enrolment
were collected. TAC at baseline was measured using a Trolox-equivalent antioxidant capacity assay. Patients were divided into two groups based on TAC levels, and various clinical parameters were compared.RESULT: Serum TAC levels correlated with forced expiratory volume in 1 second (FEV1)
at baseline (r = 0.22, P = 0.03). The group with higher baseline TAC levels maintained greater mean FEV1 both 1 and 2 years after enrolment, even after adjusting for sex, age, height, weight, body mass index and smoking status.CONCLUSION: These results suggest
an important link between serum TAC levels and pulmonary function, indicating that higher TAC levels may be a biomarker for favourable prognosis in asthma patients.</description><identifier>ISSN: 1027-3719</identifier><identifier>EISSN: 1815-7920</identifier><identifier>DOI: 10.5588/ijtld.12.0842</identifier><identifier>PMID: 23044449</identifier><language>eng</language><publisher>Paris, France: International Union Against Tuberculosis and Lung Disease</publisher><subject>Adult ; Aged ; Antioxidants ; Antioxidants - metabolism ; Antioxidants - pharmacology ; Asthma ; Asthma - physiopathology ; Biological and medical sciences ; Biomarkers - metabolism ; Chromans - pharmacology ; Chronic obstructive pulmonary disease, asthma ; Cohort Studies ; Cross-Sectional Studies ; Female ; Follow-Up Studies ; Forced Expiratory Volume ; Humans ; Longitudinal Studies ; Male ; Medical sciences ; Middle Aged ; Oxidative Stress ; Pneumology ; Prognosis ; Prospective Studies ; Republic of Korea ; Respiratory Function Tests ; Time Factors</subject><ispartof>The international journal of tuberculosis and lung disease, 2012-11, Vol.16 (11), p.1544-1550</ispartof><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-c3ce882769e5fbe287c55347c73e7a33d628137b5f374d19f58b13b135d8191a3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26496168$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23044449$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yoon, S. Y.</creatorcontrib><creatorcontrib>Kim, T-B.</creatorcontrib><creatorcontrib>Baek, S.</creatorcontrib><creatorcontrib>Kim, S.</creatorcontrib><creatorcontrib>Kwon, H-S.</creatorcontrib><creatorcontrib>Lee, Y. S.</creatorcontrib><creatorcontrib>Lee, T.</creatorcontrib><creatorcontrib>Jang, A-S.</creatorcontrib><creatorcontrib>Chang, Y-S.</creatorcontrib><creatorcontrib>Cho, S-H.</creatorcontrib><creatorcontrib>Choi, B. W.</creatorcontrib><creatorcontrib>Park, J. W.</creatorcontrib><creatorcontrib>Nham, D-H.</creatorcontrib><creatorcontrib>Yoon, H-J.</creatorcontrib><creatorcontrib>Cho, Y-J.</creatorcontrib><creatorcontrib>Park, C-S.</creatorcontrib><creatorcontrib>Moon, H-B.</creatorcontrib><creatorcontrib>Cho, Y. S.</creatorcontrib><creatorcontrib>COREA Study Group</creatorcontrib><creatorcontrib>COREA Study Group</creatorcontrib><title>The impact of total antioxidant capacity on pulmonary function in asthma patients</title><title>The international journal of tuberculosis and lung disease</title><addtitle>Int J Tuberc Lung Dis</addtitle><description>BACKGROUND: Oxidative stress, mediated by an imbalance between oxidants and antioxidants, contributes significantly to the pathogenesis of asthma.OBJECTIVE: To evaluate the impact of serum total antioxidant capacity (TAC) on the pulmonary function of Korean asthma patients.METHOD:
A total of 104 adult asthma patients enrolled from the COREA (Cohort for Reality and Evolution of Adult Asthma in Korea) programme participated in the study. Baseline clinical parameters at enrolment, and the results of pulmonary function tests at baseline and 1 and 2 years after enrolment
were collected. TAC at baseline was measured using a Trolox-equivalent antioxidant capacity assay. Patients were divided into two groups based on TAC levels, and various clinical parameters were compared.RESULT: Serum TAC levels correlated with forced expiratory volume in 1 second (FEV1)
at baseline (r = 0.22, P = 0.03). The group with higher baseline TAC levels maintained greater mean FEV1 both 1 and 2 years after enrolment, even after adjusting for sex, age, height, weight, body mass index and smoking status.CONCLUSION: These results suggest
an important link between serum TAC levels and pulmonary function, indicating that higher TAC levels may be a biomarker for favourable prognosis in asthma patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Antioxidants</subject><subject>Antioxidants - metabolism</subject><subject>Antioxidants - pharmacology</subject><subject>Asthma</subject><subject>Asthma - physiopathology</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - metabolism</subject><subject>Chromans - pharmacology</subject><subject>Chronic obstructive pulmonary disease, asthma</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Forced Expiratory Volume</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Oxidative Stress</subject><subject>Pneumology</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Republic of Korea</subject><subject>Respiratory Function Tests</subject><subject>Time Factors</subject><issn>1027-3719</issn><issn>1815-7920</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v1DAQhiMEoqVw5Ip8QeKSxWPHsX1E5VOqVLUqZ2vWsVuvEifETkX59TjdXTh1ZGlG8uN3xu9U1VugGyGU-hh2ue82wDZUNexZdQoKRC01o89LTZmsuQR9Ur1KaUcpAwD5sjphnDYl9Gl1dXPnSBgmtJmMnuQxY08w5jD-Dl3JxGK5C_mBjJFMSz-MEecH4pdoCxNJiARTvhuQTJiDizm9rl547JN7c8hn1c-vX27Ov9cXl99-nH-6qG0jdK4tt04pJlvthN86pqQVgjfSSu4kct61TAGXW-G5bDrQXqgt8HJEp0AD8rPqw153msdfi0vZDCFZ1_cY3bgkA1SLloOSuqD1HrXzmNLsvJnmMJR_FMisLppHFw0ws7pY-HcH6WU7uO4ffbStAO8PACaLvZ8x2pD-c22jW2hV4T7vuRBvizdoduMyx-KKCQuuHfd9GV07Pwa0xwIMzrkUbJ3n-ikZe1Rad72u2txDG8tjVpZNFRMGGsFN5zwufTYZZ3P7x6Qi-heyF6w7</recordid><startdate>20121101</startdate><enddate>20121101</enddate><creator>Yoon, S. Y.</creator><creator>Kim, T-B.</creator><creator>Baek, S.</creator><creator>Kim, S.</creator><creator>Kwon, H-S.</creator><creator>Lee, Y. S.</creator><creator>Lee, T.</creator><creator>Jang, A-S.</creator><creator>Chang, Y-S.</creator><creator>Cho, S-H.</creator><creator>Choi, B. W.</creator><creator>Park, J. W.</creator><creator>Nham, D-H.</creator><creator>Yoon, H-J.</creator><creator>Cho, Y-J.</creator><creator>Park, C-S.</creator><creator>Moon, H-B.</creator><creator>Cho, Y. S.</creator><creator>COREA Study Group</creator><general>International Union Against Tuberculosis and Lung Disease</general><general>International Union against Tuberculosis and Lung Disease</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20121101</creationdate><title>The impact of total antioxidant capacity on pulmonary function in asthma patients</title><author>Yoon, S. Y. ; Kim, T-B. ; Baek, S. ; Kim, S. ; Kwon, H-S. ; Lee, Y. S. ; Lee, T. ; Jang, A-S. ; Chang, Y-S. ; Cho, S-H. ; Choi, B. W. ; Park, J. W. ; Nham, D-H. ; Yoon, H-J. ; Cho, Y-J. ; Park, C-S. ; Moon, H-B. ; Cho, Y. S. ; COREA Study Group</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-c3ce882769e5fbe287c55347c73e7a33d628137b5f374d19f58b13b135d8191a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Antioxidants</topic><topic>Antioxidants - metabolism</topic><topic>Antioxidants - pharmacology</topic><topic>Asthma</topic><topic>Asthma - physiopathology</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - metabolism</topic><topic>Chromans - pharmacology</topic><topic>Chronic obstructive pulmonary disease, asthma</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Forced Expiratory Volume</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Oxidative Stress</topic><topic>Pneumology</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Republic of Korea</topic><topic>Respiratory Function Tests</topic><topic>Time Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yoon, S. Y.</creatorcontrib><creatorcontrib>Kim, T-B.</creatorcontrib><creatorcontrib>Baek, S.</creatorcontrib><creatorcontrib>Kim, S.</creatorcontrib><creatorcontrib>Kwon, H-S.</creatorcontrib><creatorcontrib>Lee, Y. S.</creatorcontrib><creatorcontrib>Lee, T.</creatorcontrib><creatorcontrib>Jang, A-S.</creatorcontrib><creatorcontrib>Chang, Y-S.</creatorcontrib><creatorcontrib>Cho, S-H.</creatorcontrib><creatorcontrib>Choi, B. W.</creatorcontrib><creatorcontrib>Park, J. W.</creatorcontrib><creatorcontrib>Nham, D-H.</creatorcontrib><creatorcontrib>Yoon, H-J.</creatorcontrib><creatorcontrib>Cho, Y-J.</creatorcontrib><creatorcontrib>Park, C-S.</creatorcontrib><creatorcontrib>Moon, H-B.</creatorcontrib><creatorcontrib>Cho, Y. S.</creatorcontrib><creatorcontrib>COREA Study Group</creatorcontrib><creatorcontrib>COREA Study Group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The international journal of tuberculosis and lung disease</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yoon, S. Y.</au><au>Kim, T-B.</au><au>Baek, S.</au><au>Kim, S.</au><au>Kwon, H-S.</au><au>Lee, Y. S.</au><au>Lee, T.</au><au>Jang, A-S.</au><au>Chang, Y-S.</au><au>Cho, S-H.</au><au>Choi, B. W.</au><au>Park, J. W.</au><au>Nham, D-H.</au><au>Yoon, H-J.</au><au>Cho, Y-J.</au><au>Park, C-S.</au><au>Moon, H-B.</au><au>Cho, Y. S.</au><au>COREA Study Group</au><aucorp>COREA Study Group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The impact of total antioxidant capacity on pulmonary function in asthma patients</atitle><jtitle>The international journal of tuberculosis and lung disease</jtitle><addtitle>Int J Tuberc Lung Dis</addtitle><date>2012-11-01</date><risdate>2012</risdate><volume>16</volume><issue>11</issue><spage>1544</spage><epage>1550</epage><pages>1544-1550</pages><issn>1027-3719</issn><eissn>1815-7920</eissn><abstract>BACKGROUND: Oxidative stress, mediated by an imbalance between oxidants and antioxidants, contributes significantly to the pathogenesis of asthma.OBJECTIVE: To evaluate the impact of serum total antioxidant capacity (TAC) on the pulmonary function of Korean asthma patients.METHOD:
A total of 104 adult asthma patients enrolled from the COREA (Cohort for Reality and Evolution of Adult Asthma in Korea) programme participated in the study. Baseline clinical parameters at enrolment, and the results of pulmonary function tests at baseline and 1 and 2 years after enrolment
were collected. TAC at baseline was measured using a Trolox-equivalent antioxidant capacity assay. Patients were divided into two groups based on TAC levels, and various clinical parameters were compared.RESULT: Serum TAC levels correlated with forced expiratory volume in 1 second (FEV1)
at baseline (r = 0.22, P = 0.03). The group with higher baseline TAC levels maintained greater mean FEV1 both 1 and 2 years after enrolment, even after adjusting for sex, age, height, weight, body mass index and smoking status.CONCLUSION: These results suggest
an important link between serum TAC levels and pulmonary function, indicating that higher TAC levels may be a biomarker for favourable prognosis in asthma patients.</abstract><cop>Paris, France</cop><pub>International Union Against Tuberculosis and Lung Disease</pub><pmid>23044449</pmid><doi>10.5588/ijtld.12.0842</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Antioxidants Antioxidants - metabolism Antioxidants - pharmacology Asthma Asthma - physiopathology Biological and medical sciences Biomarkers - metabolism Chromans - pharmacology Chronic obstructive pulmonary disease, asthma Cohort Studies Cross-Sectional Studies Female Follow-Up Studies Forced Expiratory Volume Humans Longitudinal Studies Male Medical sciences Middle Aged Oxidative Stress Pneumology Prognosis Prospective Studies Republic of Korea Respiratory Function Tests Time Factors |
| title | The impact of total antioxidant capacity on pulmonary function in asthma patients |
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