Capsaicin for Neuropathic Pain: Linking Traditional Medicine and Molecular Biology
Capsaicin has long been used as a traditional medicine to treat pain and, recently, its mechanism of analgesic action has been discovered. This review article documents the clinical development of capsaicin to demonstrate that pharmacognosy still has a profound influence on modern-day drug developme...
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| Veröffentlicht in: | European neurology 2012-01, Vol.68 (5), p.264-275 |
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| creator | Haanpää, Maija Treede, Rolf-Detlef |
| description | Capsaicin has long been used as a traditional medicine to treat pain and, recently, its mechanism of analgesic action has been discovered. This review article documents the clinical development of capsaicin to demonstrate that pharmacognosy still has a profound influence on modern-day drug development programs. Capsaicin is a highly selective agonist for the transient receptor potential channel vanilloid-receptor type 1 (TRPV1), which is expressed on central and peripheral terminals of nociceptive primary sensory neurons. Knockout studies have revealed the importance of TRPV1 as a molecular pain integrator and target for novel analgesic agents. Topical application of capsaicin at the peripheral terminal of TRPV1-expressing neurons superficially denervates the epidermis in humans in a highly selective manner and results in hypoalgesia. In three recent randomized controlled trials, a patch containing high-concentration capsaicin demonstrated meaningful efficacy and tolerability relative to a low-concentration capsaicin control patch in patients with peripheral neuropathic pain. Data from clinical practice will determine if the high-concentration capsaicin patch is effective in real-world settings. |
| doi_str_mv | 10.1159/000339944 |
| format | Article |
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This review article documents the clinical development of capsaicin to demonstrate that pharmacognosy still has a profound influence on modern-day drug development programs. Capsaicin is a highly selective agonist for the transient receptor potential channel vanilloid-receptor type 1 (TRPV1), which is expressed on central and peripheral terminals of nociceptive primary sensory neurons. Knockout studies have revealed the importance of TRPV1 as a molecular pain integrator and target for novel analgesic agents. Topical application of capsaicin at the peripheral terminal of TRPV1-expressing neurons superficially denervates the epidermis in humans in a highly selective manner and results in hypoalgesia. In three recent randomized controlled trials, a patch containing high-concentration capsaicin demonstrated meaningful efficacy and tolerability relative to a low-concentration capsaicin control patch in patients with peripheral neuropathic pain. 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| identifier | ISSN: 0014-3022 |
| ispartof | European neurology, 2012-01, Vol.68 (5), p.264-275 |
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| language | eng |
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| source | MEDLINE; Karger Journals Complete; Alma/SFX Local Collection |
| subjects | Analgesics Analgesics - therapeutic use Animals Capsaicin Capsaicin - therapeutic use Capsaicin receptors Clinical trials Data processing Drug development Epidermis Humans Medicine, Traditional Neuralgia - drug therapy Neuralgia - metabolism Neuropathy Pain perception Review Reviews Sensory neurons Topical application transient receptor potential proteins TRPV Cation Channels - agonists |
| title | Capsaicin for Neuropathic Pain: Linking Traditional Medicine and Molecular Biology |
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