Photodynamic therapy activated signaling from epidermal growth factor receptor and STAT3: Targeting survival pathways to increase PDT efficacy in ovarian and lung cancer

Patients with serosal (pleural or peritoneal) spread of malignancy have few definitive treatment options and consequently have a very poor prognosis. We have previously shown that photodynamic therapy (PDT) can be an effective treatment for these patients, but that the therapeutic index is relativel...

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Veröffentlicht in:	Cancer biology & therapy 2012-12, Vol.13 (14), p.1463-1470
Hauptverfasser:	Edmonds, Christine, Hagan, Sarah, Gallagher-Colombo, Shannon M., Busch, Theresa M., Cengel, Keith A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Agents - pharmacology Apoptosis Cell Line, Tumor Dihematoporphyrin Ether - pharmacology EGFR Erlotinib Hydrochloride Female Head and Neck Neoplasms - drug therapy Humans lung cancer Lung Neoplasms - drug therapy ovarian cancer Ovarian Neoplasms - drug therapy PDT peritoneal Photochemotherapy pleural Quinazolines - pharmacology Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - metabolism Research Paper RNA Interference RNA, Small Interfering Signal Transduction - drug effects STAT3 STAT3 Transcription Factor - antagonists & inhibitors STAT3 Transcription Factor - genetics STAT3 Transcription Factor - metabolism
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