A key phosphorylation site in AC8 mediates regulation of Ca(2+)-dependent cAMP dynamics by an AC8-AKAP79-PKA signalling complex

Adenylyl cyclase (AC) isoforms can participate in multimolecular signalling complexes incorporating A-kinase anchoring proteins (AKAPs). We recently identified a direct interaction between Ca(2+)-sensitive AC8 and plasma membrane-targeted AKAP79/150 (in cultured pancreatic insulin-secreting cells an...

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Veröffentlicht in:	Journal of cell science 2012-12, Vol.125 (Pt 23), p.5850
Hauptverfasser:	Willoughby, Debbie, Halls, Michelle L, Everett, Katy L, Ciruela, Antonio, Skroblin, Philipp, Klussmann, Enno, Cooper, Dermot M F
Format:	Artikel
Sprache:	eng
Schlagworte:	A Kinase Anchor Proteins - metabolism Adenylyl Cyclases - metabolism Blotting, Western Cell Line Cyclic AMP - metabolism Cyclic AMP-Dependent Protein Kinases - metabolism Humans Immunoprecipitation Phosphorylation
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