Immunogenicity and immune modulatory effects of in silico predicted L. donovani candidate peptide vaccines

Visceral leishmaniasis (VL) is a serious parasitic disease for which control measures are limited and drug resistance is increasing. First and second generation vaccine candidates have not been successful. The goal of the present study was to select possibly immunogenic L. donovani donovani GP63 pep...

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Veröffentlicht in:	Human vaccines & immunotherapeutics 2012-12, Vol.8 (12), p.1769-1774
Hauptverfasser:	Elfaki, Mona E.E., Khalil, Eltahir A.G., De Groot, Anne S., Musa, Ahmed M., Gutierrez, Andres, Younis, Brima M., Salih, Kawthar A.M., El-Hassan, Ahmed M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Binding Biology Bioscience Calcium Cancer Cell Computational Biology Cycle EpiMatrix Epitopes, T-Lymphocyte - genetics Epitopes, T-Lymphocyte - immunology Female Healthy Volunteers Humans Interferon-gamma - secretion Interleukin-10 - secretion Landes Leishmania donovani - genetics Leishmania donovani - immunology Leishmaniasis Vaccines - administration & dosage Leishmaniasis Vaccines - genetics Leishmaniasis Vaccines - immunology Male Metalloendopeptidases - genetics Metalloendopeptidases - immunology Organogenesis Proteins Research Paper T cell epitopes T-Lymphocytes - immunology vaccine Vaccines, Subunit - administration & dosage Vaccines, Subunit - genetics Vaccines, Subunit - immunology visceral leishmaniasis Young Adult
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