Deficiency of C―C chemokine receptor 5 suppresses tumor development via inactivation of NF―κB and inhibition of monocyte chemoattractant protein-1 in urethane-induced lung tumor model

To evaluate the significance of C-C chemokine receptor type 5 (CCR5) in lung tumor development, we compared carcinogen-induced tumor growth in CCR5 knockout (CCR5(-/-)) mice and wild-type (CCR5(+/+)) mice. CCR5(-/-) mice showed reduced urethane (1g/kg)-induced tumor incidence when compared with thos...

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Veröffentlicht in:	Carcinogenesis (New York) 2012-12, Vol.33 (12), p.2520-2528
Hauptverfasser:	NAM JIN LEE, DONG YOUNG CHOI, DONG CHEUL MOON, KIM, Youngsoo, SANG BAE HAN, JIN TAE HONG, JU KYOUNG SONG, YU YEON JUNG, DAE HAN KIM, TAE MYUNG KIM, DAE JOONG KIM, SUN MI KWON, KYUNG BO KIM, KYUNG EUN CHOI
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Apoptosis Biological and medical sciences Carcinogenesis, carcinogens and anticarcinogens CCR5 Receptor Antagonists CD8-Positive T-Lymphocytes - physiology Chemical agents Chemokine CCL2 - antagonists & inhibitors Dendritic Cells - physiology Disease Models, Animal Humans Lung Neoplasms - chemically induced Lung Neoplasms - pathology Lung Neoplasms - prevention & control Medical sciences Mice Mice, Inbred C57BL NF-kappa B - antagonists & inhibitors NF-kappa B - physiology Pneumology Receptors, CCR5 - physiology STAT3 Transcription Factor - physiology Tumors Tumors of the respiratory system and mediastinum Urethane - toxicity
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