Pore collapse underlies irreversible inactivation of TRPM2 cation channel currents

The Ca ²⁺-permeable cation channel transient receptor potential melastatin 2 (TRPM2) plays a key role in pathogen-evoked phagocyte activation, postischemic neuronal apoptosis, and glucose-evoked insulin secretion, by linking these cellular responses to oxidative stress. TRPM2 channels are coactivate...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-08, Vol.109 (33), p.13440-13445
Hauptverfasser:	Tóth, Balázs, Csanády, László
Format:	Artikel
Sprache:	eng
Schlagworte:	adenosine diphosphate Adenosine Diphosphate Ribose - metabolism Amino Acid Sequence Amino Acid Substitution - genetics Animals apoptosis Binding sites Biochemistry Biological Sciences calcium Calcium - metabolism Cations Cell Membrane Permeability Electric current Electrostatics Extracellular Space - metabolism Female insulin secretion Intracellular Space - metabolism Ion Channel Gating Ions Kinetics Ligands Molecular Sequence Data mutation Mutation - genetics Oxidative stress Patch-Clamp Techniques Pathogens Permeability phagocytes Phosphatidylinositol 4,5-Diphosphate - metabolism Physiological regulation Pipettes Porosity Protein Binding Receptors ribose Sequence Alignment Static Electricity Time constants transient receptor potential channels TRPM Cation Channels - metabolism Xenopus laevis
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