The role of cytokines in angiogenesis

Using the corneal model of neovascularization developed in their laboratory, the authors investigated the angiogenic potential of interleukin-1 (IL-1α and β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor (TNFα), transforming growth factor β (TGFβ), granulocyte macrophage-colony...

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Veröffentlicht in:Ocular immunology and inflammation 1993, Vol.1 (1-2), p.135-142
Hauptverfasser: Aharonov, O., Maftzir, G., Benezra, D.
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container_title Ocular immunology and inflammation
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creator Aharonov, O.
Maftzir, G.
Benezra, D.
description Using the corneal model of neovascularization developed in their laboratory, the authors investigated the angiogenic potential of interleukin-1 (IL-1α and β), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor (TNFα), transforming growth factor β (TGFβ), granulocyte macrophage-colony stimulating factor (GM-CSF), and interferon (IFNγ and IFNγ). Various concentrations of the tested cytokine were sequestered into Elvax-40 and implanted at 2.5 mm from the limbus within the corneal stroma of the rabbit eye. Three distinct groups of cytokines could be observed according to their angiogenic potential in this system. IL-1α was by far the most potent stimulator of neovascularization, inducing this process at concentrations as low as one nanogram per implant. TGFβ, TNFα and GM-CSF induced significant neovascularization only at concentrations of 500 nanograms per implant. IL-2, IL-6, IL-8, IFNα and IFNγ did not induce any significant neovascularization at the concentration tested (0.5 μg to 10 μg per implant).
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source Taylor & Francis:Master (3349 titles); Taylor & Francis Medical Library - CRKN
subjects angiogenesis
GM-CSF
interleukins
TGFβ
TNFα
title The role of cytokines in angiogenesis
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