Pseudomonas aeruginosa Twitching Motility: Type IV Pili in Action
Type IV pili (T4P) are one of the most common forms of bacterial and archaeal surface structures, involved in adherence, motility, competence for DNA uptake, and pathogenesis. Pseudomonas aeruginosa has emerged as one of the key model systems for the investigation of T4P structure and function. Alth...
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| description | Type IV pili (T4P) are one of the most common forms of bacterial and archaeal surface structures, involved in adherence, motility, competence for DNA uptake, and pathogenesis.
Pseudomonas aeruginosa
has emerged as one of the key model systems for the investigation of T4P structure and function. Although its reputation as a serious nosocomial and opportunistic pathogen is well deserved, its facile growth requirements and the ready availability of molecular tools have allowed for rapid advances in our understanding of how T4P are assembled; their contributions to motility, biofilm formation and virulence; and their complex regulation. This review covers recent findings concerning the three different types of T4P found in
P. aeruginosa
(type IVa, type IVb, and Tad) and provides details about the modes of translocation mediated by T4aP, the architecture and function of the T4aP assembly system, and the complex regulation of T4aP biogenesis and function. |
| doi_str_mv | 10.1146/annurev-micro-092611-150055 |
| format | Article |
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Pseudomonas aeruginosa
has emerged as one of the key model systems for the investigation of T4P structure and function. Although its reputation as a serious nosocomial and opportunistic pathogen is well deserved, its facile growth requirements and the ready availability of molecular tools have allowed for rapid advances in our understanding of how T4P are assembled; their contributions to motility, biofilm formation and virulence; and their complex regulation. This review covers recent findings concerning the three different types of T4P found in
P. aeruginosa
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Pseudomonas aeruginosa
has emerged as one of the key model systems for the investigation of T4P structure and function. Although its reputation as a serious nosocomial and opportunistic pathogen is well deserved, its facile growth requirements and the ready availability of molecular tools have allowed for rapid advances in our understanding of how T4P are assembled; their contributions to motility, biofilm formation and virulence; and their complex regulation. This review covers recent findings concerning the three different types of T4P found in
P. aeruginosa
(type IVa, type IVb, and Tad) and provides details about the modes of translocation mediated by T4aP, the architecture and function of the T4aP assembly system, and the complex regulation of T4aP biogenesis and function.</description><subject>assembly system</subject><subject>Bacteriology</subject><subject>Biofilms</subject><subject>Biological and medical sciences</subject><subject>DNA</subject><subject>fimbriae</subject><subject>Fimbriae, Bacterial - physiology</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Hospitals</subject><subject>Locomotion</subject><subject>Microbiology</subject><subject>Miscellaneous</subject><subject>Motility</subject><subject>Nutrient requirements</subject><subject>Opportunist infection</subject><subject>Pathogens</subject><subject>Pili</subject><subject>pilus</subject><subject>Protein Transport</subject><subject>Pseudomonas aeruginosa</subject><subject>Pseudomonas aeruginosa - physiology</subject><subject>Reviews</subject><subject>secretin</subject><subject>Structure-function relationships</subject><subject>Translocation</subject><subject>Twitching</subject><subject>type IVa</subject><subject>type IVb</subject><subject>Virulence</subject><issn>0066-4227</issn><issn>1545-3251</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkF1LwzAUhoMobk7_ghRE8KZ6kjYJ0RvH8Asm7mJ6W7I0mZE2nU3r2L83s1VvlUBCwnPeNzwInWA4xzhlF9K5ttYfcWlVXcUgCMM4xhSA0h00xDSlcUIo3kVDAMbilBA-QAfevwFAykHso0F4SlmS4CEaz7xu86qsnPSR1HW7tK7yMpqvbaNerVtGj1VjC9tsLqP5ZqWjh5doFu6RddFYNbZyh2jPyMLro_4coefbm_nkPp4-3T1MxtNYUuBNzBgorAwoZnKWGwapThnmORFGJbk2iVyEHSBXhDKx0EYQAkwzkackLJGM0FmXu6qr91b7JiutV7oopNNV6zNMKOeUY_wHFJgI4SKhAb3q0ODS-1qbbFXbUtabAGVb3VmvO_vSnXW6s053mD7ui9pFqfOf2W-_ATjtAemVLEwtnbL-l2M84YC3Qdcdt22TReizeu3_9ZdPATSh9Q</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Burrows, Lori L</creator><general>Annual Reviews</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>20120101</creationdate><title>Pseudomonas aeruginosa Twitching Motility: Type IV Pili in Action</title><author>Burrows, Lori L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a507t-660c1cf0c6fd6df604e4617d29fc3def3abdef00dc2569bef92206e69d4242493</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>assembly system</topic><topic>Bacteriology</topic><topic>Biofilms</topic><topic>Biological and medical sciences</topic><topic>DNA</topic><topic>fimbriae</topic><topic>Fimbriae, Bacterial - physiology</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Hospitals</topic><topic>Locomotion</topic><topic>Microbiology</topic><topic>Miscellaneous</topic><topic>Motility</topic><topic>Nutrient requirements</topic><topic>Opportunist infection</topic><topic>Pathogens</topic><topic>Pili</topic><topic>pilus</topic><topic>Protein Transport</topic><topic>Pseudomonas aeruginosa</topic><topic>Pseudomonas aeruginosa - physiology</topic><topic>Reviews</topic><topic>secretin</topic><topic>Structure-function relationships</topic><topic>Translocation</topic><topic>Twitching</topic><topic>type IVa</topic><topic>type IVb</topic><topic>Virulence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Burrows, Lori L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Annual review of microbiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Burrows, Lori L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Pseudomonas aeruginosa Twitching Motility: Type IV Pili in Action</atitle><jtitle>Annual review of microbiology</jtitle><addtitle>Annu Rev Microbiol</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>66</volume><issue>1</issue><spage>493</spage><epage>520</epage><pages>493-520</pages><issn>0066-4227</issn><eissn>1545-3251</eissn><coden>ARMIAZ</coden><abstract>Type IV pili (T4P) are one of the most common forms of bacterial and archaeal surface structures, involved in adherence, motility, competence for DNA uptake, and pathogenesis.
Pseudomonas aeruginosa
has emerged as one of the key model systems for the investigation of T4P structure and function. Although its reputation as a serious nosocomial and opportunistic pathogen is well deserved, its facile growth requirements and the ready availability of molecular tools have allowed for rapid advances in our understanding of how T4P are assembled; their contributions to motility, biofilm formation and virulence; and their complex regulation. This review covers recent findings concerning the three different types of T4P found in
P. aeruginosa
(type IVa, type IVb, and Tad) and provides details about the modes of translocation mediated by T4aP, the architecture and function of the T4aP assembly system, and the complex regulation of T4aP biogenesis and function.</abstract><cop>Palo Alto, CA</cop><pub>Annual Reviews</pub><pmid>22746331</pmid><doi>10.1146/annurev-micro-092611-150055</doi><tpages>28</tpages></addata></record> |
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| ispartof | Annual review of microbiology, 2012-01, Vol.66 (1), p.493-520 |
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| source | Annual Reviews; MEDLINE |
| subjects | assembly system Bacteriology Biofilms Biological and medical sciences DNA fimbriae Fimbriae, Bacterial - physiology Fundamental and applied biological sciences. Psychology Hospitals Locomotion Microbiology Miscellaneous Motility Nutrient requirements Opportunist infection Pathogens Pili pilus Protein Transport Pseudomonas aeruginosa Pseudomonas aeruginosa - physiology Reviews secretin Structure-function relationships Translocation Twitching type IVa type IVb Virulence |
| title | Pseudomonas aeruginosa Twitching Motility: Type IV Pili in Action |
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