Involvement of the cysteine-rich head domain in activation and desensitization of the P2X1 receptor

P2X receptors (P2XRs) are ligand-gated ion channels activated by extracellular ATP. Although the crystal structure of the zebrafish P2X4R has been solved, the exact mode of ATP binding and the conformational changes governing channel opening and desensitization remain unknown. Here, we used voltage...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-07, Vol.109 (28), p.11396-11401
Hauptverfasser:	Lörinczi, Éva, Bhargava, Yogesh, Marino, Stephen F, Taly, Antoine, Kaczmarek-Hájek, Karina, Barrantes-Freer, Alonso, Dutertre, Sébastien, Grutter, Thomas, Rettinger, Jürgen, Nicke, Annette
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine triphosphatase adenosine triphosphate Agonists Amino acids Animals antagonists Binding sites Biochemistry, Molecular Biology Biological Sciences Cations Cell Membrane - metabolism Crystal structure Crystallography, X-Ray - methods cysteine Cysteine - chemistry Danio rerio DNA, Complementary - metabolism Electrophysiology - methods Fluorescence fluorometry Inurement Ion channels Kinetics Life Sciences Ligands Maleimides - chemistry Microscopy, Fluorescence - methods molecular models mutants Mutation Oocytes Oocytes - metabolism Protein Binding Protein Structure, Tertiary Proteins Rats Receptors Receptors, Purinergic P2X1 - metabolism Rhodamines - chemistry ribose Time constants Xenopus - metabolism Xenopus laevis - metabolism Zebrafish
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