Production and characterization of a colon cancer-specific immunotoxin based on the fungal ribotoxin α-sarcin

A single-chain fusion protein that directed the cytolytic activity of α-sarcin to A33 tumor antigen expressing cells was constructed and shown to effectively kill targeted cells. Glycoprotein A33 (GPA33) is a well-known colon cancer marker and a humanized antibody against it was used to target the α...

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Veröffentlicht in:	Protein engineering, design and selection design and selection, 2012-08, Vol.25 (8), p.425-435
Hauptverfasser:	Carreras-Sangrà, Nelson, Tomé-Amat, Jaime, García-Ortega, Lucía, Batt, Carl A., Oñaderra, Mercedes, Martínez-del-Pozo, Álvaro, Gavilanes, José G., Lacadena, Javier
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Line, Tumor Colonic Neoplasms - drug therapy Colonic Neoplasms - immunology Colonic Neoplasms - metabolism Endoribonucleases - chemistry Endoribonucleases - genetics Endoribonucleases - metabolism Flow Cytometry Fungal Proteins - chemistry Fungal Proteins - genetics Fungal Proteins - metabolism Humans Immunotoxins - chemistry Immunotoxins - genetics Immunotoxins - metabolism Membrane Glycoproteins - chemistry Membrane Glycoproteins - genetics Membrane Glycoproteins - metabolism Microscopy, Fluorescence Pichia - genetics Recombinant Fusion Proteins - chemistry Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - isolation & purification Recombinant Fusion Proteins - metabolism Single-Chain Antibodies - chemistry Single-Chain Antibodies - genetics Single-Chain Antibodies - metabolism
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