Interrupting the Early Region of Polyoma Virus DNA Enhances Tumorigenicity

The tumorigenicity of DNA from polyoma virus after cleavage with a variety of restriction enzymes was evaluated in suckling hamsters. Cleavage with enzymes that interrupt the region of the genome coding for the large tumor (T) antigen of polyoma virus markedly enhanced the tumorigenicity above that...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 1979-08, Vol.76 (8), p.3713-3716
Hauptverfasser:	Israel, Mark A., Simmons, Daniel T., Hourihan, Sara L., Rowe, Wallace P., Martin, Malcolm A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antigens, Neoplasm - genetics Base Sequence Cell lines Cell Transformation, Viral Cricetinae DNA DNA, Viral - genetics Enzymes Genes, Viral Hamsters Molecular Weight Neoplasms, Experimental - microbiology Polyomavirus Polyomavirus - genetics Polyomavirus - pathogenicity Transformed cell line Tumor cell line Tumors Viral DNA Viral genomes Viral Proteins - genetics
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