Effect of polyamine oxidase inhibition on the colonic malignant transformation process induced by 1,2-dimethylhydrazine

Recent studies of colon adenocarcinomas in humans and experimentally induced colonic tumors in rodents have demonstrated selective elevations in the level of N1-acetylspermidine in these malignant tissues. The exact relationship of these alterations in acetylated polyamine levels to the malignant tr...

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Veröffentlicht in:	Carcinogenesis (New York) 1990-12, Vol.11 (12), p.2127-2132
Hauptverfasser:	HALLINE, A. G, DUDEJA, P. K, JACOBY, R. F, LLOR, X, BA-BIE TENG, CHOWDHURY, L. N, DAVIDSON, N. O, BRASITUS, T. A
Format:	Artikel
Sprache:	eng
Schlagworte:	1,2-Dimethylhydrazine Acetyltransferases - analysis Adenocarcinoma - chemically induced Adenocarcinoma - prevention & control Animal tumors. Experimental tumors Animals Base Sequence Biological and medical sciences Carcinogens - pharmacology Colon - chemistry Colonic Neoplasms - chemically induced Colonic Neoplasms - prevention & control Dimethylhydrazines - pharmacology Experimental digestive system and abdominal tumors Genes, ras - genetics Male Medical sciences Molecular Sequence Data Neoplasms, Experimental Ornithine Decarboxylase - analysis Oxidoreductases Acting on CH-NH Group Donors - analysis Oxidoreductases Acting on CH-NH Group Donors - antagonists & inhibitors Polyamine Oxidase Polymerase Chain Reaction Putrescine - analogs & derivatives Putrescine - pharmacology Rats Rats, Inbred Strains Tumors
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