Naturally occurring endo-siRNA silences LINE-1 retrotransposons in human cells through DNA methylation

Long interspersed nuclear element 1 (LINE-1) retrotransposons are mutagens that are capable of generating deleterious mutations by inserting themselves into genes and affecting gene function in the human genome. In normal cells, the activity of LINE-1 retrotransposon is mostly repressed, maintaining...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Epigenetics 2012-07, Vol.7 (7), p.758-771
Hauptverfasser:	Chen, Long, Dahlstrom, Jane E., Lee, Sung-Hun, Rangasamy, Danny
Format:	Artikel
Sprache:	eng
Schlagworte:	Binding Biology Bioscience Calcium Cancer Cell Cell Line, Tumor Cycle DNA Methylation endogenous small RNAs Gene Silencing High-Throughput Nucleotide Sequencing human cancer cells Humans Landes Long Interspersed Nucleotide Elements - genetics Organogenesis Proteins retrotransposons RNA, Small Interfering - metabolism RNAi pathway Sequence Analysis, DNA
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!