Mechanisms contributing to central excitability changes during hearing loss

Exposure to loud sound causes cochlear damage resulting in hearing loss and tinnitus. Tinnitus has been related to hyperactivity in the central auditory pathway occurring weeks after loud sound exposure. However, central excitability changes concomitant to hearing loss and preceding those periods of...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-05, Vol.109 (21), p.8292-8297
Hauptverfasser:	Pilati, Nadia, Ison, Matias J, Barker, Matthew, Mulheran, Mike, Large, Charles H, Forsythe, Ian D, Matthias, John, Hamann, Martine
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Auditory Pathways - pathology Auditory Pathways - physiopathology Auditory Threshold - physiology Behavioral neuroscience Biological Sciences Cell membranes Cells Cochlea Cochlea - pathology Cochlea - physiopathology Cochlear Nerve - pathology Cochlear Nerve - physiopathology Cochlear nucleus Cochlear Nucleus - pathology Cochlear Nucleus - physiopathology Ears & hearing Electric potential Excitatory Postsynaptic Potentials - physiology hearing Hearing loss Hearing Loss, Noise-Induced - pathology Hearing Loss, Noise-Induced - physiopathology Humans Inhibitory Postsynaptic Potentials - physiology nerve fibers Nerve Fibers, Myelinated - pathology Nerve Fibers, Myelinated - physiology nerve tissue Neural Inhibition - physiology Neurons Patch-Clamp Techniques Proteins Rats Rats, Wistar Signal transduction Synaptic transmission Tinnitus Tinnitus - pathology Tinnitus - physiopathology Transfer functions
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