Two Crucial Early Steps in RNA Synthesis by the Hepatitis C Virus Polymerase Involve a Dual Role of Residue 405

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Veröffentlicht in:	Journal of Virology 2012-07, Vol.86 (13), p.7107-7117
Hauptverfasser:	Scrima, Nathalie, Caillet-Saguy, Célia, Ventura, Michel, Harrus, Déborah, Astier-Gin, Thérèse, Bressanelli, Stéphane
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Biological and medical sciences Crystallography, X-Ray Fundamental and applied biological sciences. Psychology Genome and Regulation of Viral Gene Expression Hepacivirus Hepacivirus - enzymology Hepacivirus - physiology Hepatitis C virus Humans Life Sciences Microbiology Miscellaneous Models, Molecular Mutagenesis, Site-Directed Mutant Proteins Mutant Proteins - chemistry Mutant Proteins - genetics Mutant Proteins - metabolism Mutation, Missense Protein Conformation RNA, Viral RNA, Viral - biosynthesis RNA-Dependent RNA Polymerase RNA-Dependent RNA Polymerase - chemistry RNA-Dependent RNA Polymerase - genetics RNA-Dependent RNA Polymerase - metabolism Viral Nonstructural Proteins Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - genetics Viral Nonstructural Proteins - metabolism Virology Virus Replication
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