Inhibition of antibody response to Pseudomonas exotoxin and an immunotoxin containing Pseudomonas exotoxin by 15-deoxyspergualin in mice

Immunotoxins are potent cell-killing agents that may be useful in the treatment of cancer. The early production of neutralizing antibodies to immunotoxins is one of the major limiting factors for their use in humans. 15-Deoxyspergualin (DSG), a derivative of spergualin, which is a metabolite of Baci...

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Veröffentlicht in:	Cancer research (Chicago, Ill.) Ill.), 1990-12, Vol.50 (24), p.7750-7753
Hauptverfasser:	PAI, L. H, FITZGERALD, D. J, TEPPER, M, SCHACTER, B, SPITALNY, G, PASTAN, I
Format:	Artikel
Sprache:	eng
Schlagworte:	ADP Ribose Transferases Animals Antibody Formation - drug effects Bacterial Toxins Biological and medical sciences Cell Line Enzyme-Linked Immunosorbent Assay Exotoxins - immunology Exotoxins - toxicity Guanidines - pharmacology Humans Immunoglobulin G - biosynthesis Immunoglobulin M - biosynthesis Immunomodulators Immunosuppressive Agents - pharmacology Immunotoxins - toxicity Male Medical sciences Mice Mice, Inbred Strains Neutralization Tests Pharmacology. Drug treatments Pseudomonas Pseudomonas aeruginosa Exotoxin A Recombinant Proteins - toxicity Virulence Factors
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