Digital Microfluidics

Digital microfluidics (DMF) is an emerging liquid-handling technology that enables individual control over droplets on an open array of electrodes. These picoliter- to microliter-sized droplets, each serving as an isolated vessel for chemical processes, can be made to move, merge, split, and dispens...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Annual review of analytical chemistry (Palo Alto, Calif.) Calif.), 2012-07, Vol.5 (1), p.413-440
Hauptverfasser: Choi, Kihwan, Ng, Alphonsus H.C, Fobel, Ryan, Wheeler, Aaron R
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 440
container_issue 1
container_start_page 413
container_title Annual review of analytical chemistry (Palo Alto, Calif.)
container_volume 5
creator Choi, Kihwan
Ng, Alphonsus H.C
Fobel, Ryan
Wheeler, Aaron R
description Digital microfluidics (DMF) is an emerging liquid-handling technology that enables individual control over droplets on an open array of electrodes. These picoliter- to microliter-sized droplets, each serving as an isolated vessel for chemical processes, can be made to move, merge, split, and dispense from reservoirs. Because of its unique advantages, including simple instrumentation, flexible device geometry, and easy coupling with other technologies, DMF is being applied to a wide range of fields. In this review, we summarize the state of the art of DMF technology from the perspective of analytical chemistry in sections describing the theory of droplet actuation, device fabrication and integration, and applications.
doi_str_mv 10.1146/annurev-anchem-062011-143028
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmed_primary_22524226</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1021256673</sourcerecordid><originalsourceid>FETCH-LOGICAL-a447t-3ea0277df091b8581a95353d24e417964b1515fe169ba04e2d382b3d320ed0653</originalsourceid><addsrcrecordid>eNqVkD1PwzAQhi0EoqUwsiIGBhaD7852EomlKp9SEQvMlhM7YJSkJW6K-PekSunOdDc873unh7ELEFcAUl_bpulav-a2KT58zYVGAcBBksB0j40hI82BSO3vdkxG7CjGTyG0IKJDNkJUKBH1mJ3ehvewstX5cyjaRVl1wYUiHrOD0lbRn2znhL3d373OHvn85eFpNp1zK2Wy4uStwCRxpcggT1UKNlOkyKH0EpJMyxwUqNKDznIrpEdHKebkCIV3QiuasMuhd9kuvjofV6YOsfBVZRu_6KIBgYBK64R69GZA-zdjbH1plm2obfvTQ2YjxmzFmEGMGcSYQUwfP9te6vLau134z0QPTAdgU2Orvij47_i_I79JAnbF</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1021256673</pqid></control><display><type>article</type><title>Digital Microfluidics</title><source>Annual Reviews</source><source>MEDLINE</source><creator>Choi, Kihwan ; Ng, Alphonsus H.C ; Fobel, Ryan ; Wheeler, Aaron R</creator><creatorcontrib>Choi, Kihwan ; Ng, Alphonsus H.C ; Fobel, Ryan ; Wheeler, Aaron R</creatorcontrib><description>Digital microfluidics (DMF) is an emerging liquid-handling technology that enables individual control over droplets on an open array of electrodes. These picoliter- to microliter-sized droplets, each serving as an isolated vessel for chemical processes, can be made to move, merge, split, and dispense from reservoirs. Because of its unique advantages, including simple instrumentation, flexible device geometry, and easy coupling with other technologies, DMF is being applied to a wide range of fields. In this review, we summarize the state of the art of DMF technology from the perspective of analytical chemistry in sections describing the theory of droplet actuation, device fabrication and integration, and applications.</description><identifier>ISSN: 1936-1327</identifier><identifier>EISSN: 1936-1335</identifier><identifier>DOI: 10.1146/annurev-anchem-062011-143028</identifier><identifier>PMID: 22524226</identifier><language>eng</language><publisher>United States: Annual Reviews</publisher><subject>Animals ; bioanalysis ; Cell Culture Techniques - instrumentation ; Chemistry Techniques, Analytical - instrumentation ; diagnosis ; dielectrophoresis ; DNA - analysis ; droplet ; electrowetting on dielectric ; Enzyme Assays - instrumentation ; Equipment Design ; Humans ; Immunoassay - instrumentation ; Microfluidic Analytical Techniques - instrumentation ; proteomics ; Proteomics - instrumentation</subject><ispartof>Annual review of analytical chemistry (Palo Alto, Calif.), 2012-07, Vol.5 (1), p.413-440</ispartof><rights>Copyright © 2012 by Annual Reviews. All rights reserved 2012</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a447t-3ea0277df091b8581a95353d24e417964b1515fe169ba04e2d382b3d320ed0653</citedby><cites>FETCH-LOGICAL-a447t-3ea0277df091b8581a95353d24e417964b1515fe169ba04e2d382b3d320ed0653</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev-anchem-062011-143028?crawler=true&amp;mimetype=application/pdf$$EPDF$$P50$$Gannualreviews$$H</linktopdf><linktohtml>$$Uhttps://www.annualreviews.org/content/journals/10.1146/annurev-anchem-062011-143028$$EHTML$$P50$$Gannualreviews$$H</linktohtml><link.rule.ids>70,314,776,780,4167,27903,27904,78000,78001</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22524226$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Choi, Kihwan</creatorcontrib><creatorcontrib>Ng, Alphonsus H.C</creatorcontrib><creatorcontrib>Fobel, Ryan</creatorcontrib><creatorcontrib>Wheeler, Aaron R</creatorcontrib><title>Digital Microfluidics</title><title>Annual review of analytical chemistry (Palo Alto, Calif.)</title><addtitle>Annu Rev Anal Chem (Palo Alto Calif)</addtitle><description>Digital microfluidics (DMF) is an emerging liquid-handling technology that enables individual control over droplets on an open array of electrodes. These picoliter- to microliter-sized droplets, each serving as an isolated vessel for chemical processes, can be made to move, merge, split, and dispense from reservoirs. Because of its unique advantages, including simple instrumentation, flexible device geometry, and easy coupling with other technologies, DMF is being applied to a wide range of fields. In this review, we summarize the state of the art of DMF technology from the perspective of analytical chemistry in sections describing the theory of droplet actuation, device fabrication and integration, and applications.</description><subject>Animals</subject><subject>bioanalysis</subject><subject>Cell Culture Techniques - instrumentation</subject><subject>Chemistry Techniques, Analytical - instrumentation</subject><subject>diagnosis</subject><subject>dielectrophoresis</subject><subject>DNA - analysis</subject><subject>droplet</subject><subject>electrowetting on dielectric</subject><subject>Enzyme Assays - instrumentation</subject><subject>Equipment Design</subject><subject>Humans</subject><subject>Immunoassay - instrumentation</subject><subject>Microfluidic Analytical Techniques - instrumentation</subject><subject>proteomics</subject><subject>Proteomics - instrumentation</subject><issn>1936-1327</issn><issn>1936-1335</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqVkD1PwzAQhi0EoqUwsiIGBhaD7852EomlKp9SEQvMlhM7YJSkJW6K-PekSunOdDc873unh7ELEFcAUl_bpulav-a2KT58zYVGAcBBksB0j40hI82BSO3vdkxG7CjGTyG0IKJDNkJUKBH1mJ3ehvewstX5cyjaRVl1wYUiHrOD0lbRn2znhL3d373OHvn85eFpNp1zK2Wy4uStwCRxpcggT1UKNlOkyKH0EpJMyxwUqNKDznIrpEdHKebkCIV3QiuasMuhd9kuvjofV6YOsfBVZRu_6KIBgYBK64R69GZA-zdjbH1plm2obfvTQ2YjxmzFmEGMGcSYQUwfP9te6vLau134z0QPTAdgU2Orvij47_i_I79JAnbF</recordid><startdate>20120719</startdate><enddate>20120719</enddate><creator>Choi, Kihwan</creator><creator>Ng, Alphonsus H.C</creator><creator>Fobel, Ryan</creator><creator>Wheeler, Aaron R</creator><general>Annual Reviews</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20120719</creationdate><title>Digital Microfluidics</title><author>Choi, Kihwan ; Ng, Alphonsus H.C ; Fobel, Ryan ; Wheeler, Aaron R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a447t-3ea0277df091b8581a95353d24e417964b1515fe169ba04e2d382b3d320ed0653</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Animals</topic><topic>bioanalysis</topic><topic>Cell Culture Techniques - instrumentation</topic><topic>Chemistry Techniques, Analytical - instrumentation</topic><topic>diagnosis</topic><topic>dielectrophoresis</topic><topic>DNA - analysis</topic><topic>droplet</topic><topic>electrowetting on dielectric</topic><topic>Enzyme Assays - instrumentation</topic><topic>Equipment Design</topic><topic>Humans</topic><topic>Immunoassay - instrumentation</topic><topic>Microfluidic Analytical Techniques - instrumentation</topic><topic>proteomics</topic><topic>Proteomics - instrumentation</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Choi, Kihwan</creatorcontrib><creatorcontrib>Ng, Alphonsus H.C</creatorcontrib><creatorcontrib>Fobel, Ryan</creatorcontrib><creatorcontrib>Wheeler, Aaron R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Annual review of analytical chemistry (Palo Alto, Calif.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Choi, Kihwan</au><au>Ng, Alphonsus H.C</au><au>Fobel, Ryan</au><au>Wheeler, Aaron R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Digital Microfluidics</atitle><jtitle>Annual review of analytical chemistry (Palo Alto, Calif.)</jtitle><addtitle>Annu Rev Anal Chem (Palo Alto Calif)</addtitle><date>2012-07-19</date><risdate>2012</risdate><volume>5</volume><issue>1</issue><spage>413</spage><epage>440</epage><pages>413-440</pages><issn>1936-1327</issn><eissn>1936-1335</eissn><abstract>Digital microfluidics (DMF) is an emerging liquid-handling technology that enables individual control over droplets on an open array of electrodes. These picoliter- to microliter-sized droplets, each serving as an isolated vessel for chemical processes, can be made to move, merge, split, and dispense from reservoirs. Because of its unique advantages, including simple instrumentation, flexible device geometry, and easy coupling with other technologies, DMF is being applied to a wide range of fields. In this review, we summarize the state of the art of DMF technology from the perspective of analytical chemistry in sections describing the theory of droplet actuation, device fabrication and integration, and applications.</abstract><cop>United States</cop><pub>Annual Reviews</pub><pmid>22524226</pmid><doi>10.1146/annurev-anchem-062011-143028</doi><tpages>28</tpages></addata></record>
fulltext fulltext
identifier ISSN: 1936-1327
ispartof Annual review of analytical chemistry (Palo Alto, Calif.), 2012-07, Vol.5 (1), p.413-440
issn 1936-1327
1936-1335
language eng
recordid cdi_pubmed_primary_22524226
source Annual Reviews; MEDLINE
subjects Animals
bioanalysis
Cell Culture Techniques - instrumentation
Chemistry Techniques, Analytical - instrumentation
diagnosis
dielectrophoresis
DNA - analysis
droplet
electrowetting on dielectric
Enzyme Assays - instrumentation
Equipment Design
Humans
Immunoassay - instrumentation
Microfluidic Analytical Techniques - instrumentation
proteomics
Proteomics - instrumentation
title Digital Microfluidics
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-25T00%3A45%3A19IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Digital%20Microfluidics&rft.jtitle=Annual%20review%20of%20analytical%20chemistry%20(Palo%20Alto,%20Calif.)&rft.au=Choi,%20Kihwan&rft.date=2012-07-19&rft.volume=5&rft.issue=1&rft.spage=413&rft.epage=440&rft.pages=413-440&rft.issn=1936-1327&rft.eissn=1936-1335&rft_id=info:doi/10.1146/annurev-anchem-062011-143028&rft_dat=%3Cproquest_pubme%3E1021256673%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1021256673&rft_id=info:pmid/22524226&rfr_iscdi=true