The Polycomb complex PRC2 supports aberrant self-renewal in a mouse model of MLL-AF9;Nras(G12D) acute myeloid leukemia

The Trithorax and Polycomb groups of chromatin regulators are critical for cell-lineage specification during normal development; functions that often become deregulated during tumorigenesis. As an example, oncogenic fusions of the Trithorax-related protein mixed lineage leukemia (MLL) can initiate a...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Oncogene 2013-02, Vol.32 (7), p.930
Hauptverfasser:	Shi, J, Wang, E, Zuber, J, Rappaport, A, Taylor, M, Johns, C, Lowe, S W, Vakoc, C R
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acid Substitution Animals Aspartic Acid - genetics Cell Proliferation Disease Models, Animal Genes, ras - genetics Glycine - genetics Humans Leukemia, Myeloid, Acute - genetics Leukemia, Myeloid, Acute - metabolism Leukemia, Myeloid, Acute - pathology Mice Mice, Transgenic Models, Biological Mutation, Missense - physiology Oncogene Proteins, Fusion - genetics Polycomb Repressive Complex 2 - genetics Polycomb Repressive Complex 2 - metabolism Polycomb Repressive Complex 2 - physiology Polycomb-Group Proteins - genetics Polycomb-Group Proteins - physiology Tumor Cells, Cultured
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!