Effects of a non-selective TRPC channel blocker, SKF-96365, on melittin- induced spontaneous persistent nociception and inflammatory pain hypersensitivity

Objective Melittin is the main peptide in bee venom and causes both persistent spontaneous nociception and pain hypersensitivity. Our recent studies indicated that both transient receptor potential （TRP） vanilloid receptor 1 （TRPV 1） and canonical TRPs （TRPCs） are involved in mediating the melittin-...

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Veröffentlicht in:	Neuroscience bulletin 2012-04, Vol.28 (2), p.173-181
Hauptverfasser:	Ding, Jing, Zhang, Jia-Rui, Wang, Yan, Li, Chun-Li, Lu, Dan, Guan, Su-Min, Chen, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Calcium Channel Blockers - pharmacology Chronic Pain - chemically induced Chronic Pain - drug therapy Chronic Pain - pathology Disease Models, Animal Ganglia, Spinal - drug effects Ganglia, Spinal - pathology Imidazoles - pharmacology Inflammation - complications Inflammation - drug therapy Inflammation - pathology Inflammation Mediators - physiology Male Melitten - pharmacology Nociceptors - drug effects Nociceptors - pathology Rats Rats, Sprague-Dawley TRPC Cation Channels - antagonists & inhibitors TRPC Cation Channels - physiology 伤害性反应蜂毒肽诱导超敏反应辣椒素受体通道阻滞剂非选择性
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