Does Antidepressant Treatment Improve Cognition in Older People with Schizophrenia or Schizoaffective Disorder and Comorbid Subsyndromal Depression?
Background: Subsyndromal symptoms of depression (SSD) in patients with schizophrenia are common and clinically important. While treatment of depression in major depressive disorder may partially ameliorate cognitive deficits, the cognitive effects of antidepressant medications in patients with schiz...
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| Veröffentlicht in: | Neuropsychobiology 2012-04, Vol.65 (3), p.168-172 |
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| creator | Dawes, Sharron E. Palmer, Barton W. Meeks, Thomas Golshan, Shahrokh Kasckow, John Mohamed, Somaia Zisook, Sidney |
| description | Background: Subsyndromal symptoms of depression (SSD) in patients with schizophrenia are common and clinically important. While treatment of depression in major depressive disorder may partially ameliorate cognitive deficits, the cognitive effects of antidepressant medications in patients with schizophrenia or schizoaffective disorder and SSD are unknown. Methods: The goal of this study was to assess the impact of SSD and their treatment on cognition in participants with schizophrenia or schizoaffective disorder aged ≧40 years. Participants were randomly assigned to a flexible dose treatment with citalopram or placebo augmentation of their current medication for 12 weeks. An ANCOVA compared improvement in the cognitive composite scores, and a linear model determined the moderation of cognition on treatment effects based on the Hamilton Depression Rating Scale and the Calgary Depression Rating Scale scores between treatment groups. Results: There were no differences between the citalopram and placebo groups in changes in cognition. Baseline cognitive status did not moderate antidepressant treatment response. Conclusions: Although there are other cogent reasons why SSD in schizophrenia warrant direct intervention, treatment does not substantially affect the level of cognitive functioning. Given the effects of cognitive deficits associated with schizophrenia on functional disability, there remains an ongoing need to identify effective means of directly ameliorating them. |
| doi_str_mv | 10.1159/000331141 |
| format | Article |
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While treatment of depression in major depressive disorder may partially ameliorate cognitive deficits, the cognitive effects of antidepressant medications in patients with schizophrenia or schizoaffective disorder and SSD are unknown. Methods: The goal of this study was to assess the impact of SSD and their treatment on cognition in participants with schizophrenia or schizoaffective disorder aged ≧40 years. Participants were randomly assigned to a flexible dose treatment with citalopram or placebo augmentation of their current medication for 12 weeks. An ANCOVA compared improvement in the cognitive composite scores, and a linear model determined the moderation of cognition on treatment effects based on the Hamilton Depression Rating Scale and the Calgary Depression Rating Scale scores between treatment groups. Results: There were no differences between the citalopram and placebo groups in changes in cognition. Baseline cognitive status did not moderate antidepressant treatment response. Conclusions: Although there are other cogent reasons why SSD in schizophrenia warrant direct intervention, treatment does not substantially affect the level of cognitive functioning. Given the effects of cognitive deficits associated with schizophrenia on functional disability, there remains an ongoing need to identify effective means of directly ameliorating them.</description><identifier>ISSN: 0302-282X</identifier><identifier>EISSN: 1423-0224</identifier><identifier>DOI: 10.1159/000331141</identifier><identifier>PMID: 22456094</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adult ; Aging ; Antidepressants ; Antidepressive Agents - therapeutic use ; citalopram ; Citalopram - therapeutic use ; Cognition Disorders - drug therapy ; Cognition Disorders - etiology ; Cognitive ability ; Comorbidity ; Depression ; Depression - complications ; Depression - epidemiology ; Double-Blind Method ; Female ; Humans ; Male ; Mental disorders ; Middle Aged ; Neuropsychological Tests ; Original Paper ; Psychiatric Status Rating Scales ; Psychotic Disorders - complications ; Psychotic Disorders - epidemiology ; Schizophrenia ; Schizophrenia - complications ; Schizophrenia - epidemiology</subject><ispartof>Neuropsychobiology, 2012-04, Vol.65 (3), p.168-172</ispartof><rights>2012 S. Karger AG, Basel</rights><rights>Copyright © 2012 S. Karger AG, Basel.</rights><rights>Copyright (c) 2012 S. Karger AG, Basel</rights><rights>Copyright © 2012 by S. Karger AG, Basel 2012</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c457t-824fe463bcfe77fa49b606b27a5470118427bed7838e4d0b3ba0a614ac78b1233</citedby><cites>FETCH-LOGICAL-c457t-824fe463bcfe77fa49b606b27a5470118427bed7838e4d0b3ba0a614ac78b1233</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,2423,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22456094$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dawes, Sharron E.</creatorcontrib><creatorcontrib>Palmer, Barton W.</creatorcontrib><creatorcontrib>Meeks, Thomas</creatorcontrib><creatorcontrib>Golshan, Shahrokh</creatorcontrib><creatorcontrib>Kasckow, John</creatorcontrib><creatorcontrib>Mohamed, Somaia</creatorcontrib><creatorcontrib>Zisook, Sidney</creatorcontrib><title>Does Antidepressant Treatment Improve Cognition in Older People with Schizophrenia or Schizoaffective Disorder and Comorbid Subsyndromal Depression?</title><title>Neuropsychobiology</title><addtitle>Neuropsychobiology</addtitle><description>Background: Subsyndromal symptoms of depression (SSD) in patients with schizophrenia are common and clinically important. While treatment of depression in major depressive disorder may partially ameliorate cognitive deficits, the cognitive effects of antidepressant medications in patients with schizophrenia or schizoaffective disorder and SSD are unknown. Methods: The goal of this study was to assess the impact of SSD and their treatment on cognition in participants with schizophrenia or schizoaffective disorder aged ≧40 years. Participants were randomly assigned to a flexible dose treatment with citalopram or placebo augmentation of their current medication for 12 weeks. An ANCOVA compared improvement in the cognitive composite scores, and a linear model determined the moderation of cognition on treatment effects based on the Hamilton Depression Rating Scale and the Calgary Depression Rating Scale scores between treatment groups. Results: There were no differences between the citalopram and placebo groups in changes in cognition. Baseline cognitive status did not moderate antidepressant treatment response. Conclusions: Although there are other cogent reasons why SSD in schizophrenia warrant direct intervention, treatment does not substantially affect the level of cognitive functioning. Given the effects of cognitive deficits associated with schizophrenia on functional disability, there remains an ongoing need to identify effective means of directly ameliorating them.</description><subject>Adult</subject><subject>Aging</subject><subject>Antidepressants</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>citalopram</subject><subject>Citalopram - therapeutic use</subject><subject>Cognition Disorders - drug therapy</subject><subject>Cognition Disorders - etiology</subject><subject>Cognitive ability</subject><subject>Comorbidity</subject><subject>Depression</subject><subject>Depression - complications</subject><subject>Depression - epidemiology</subject><subject>Double-Blind Method</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Mental disorders</subject><subject>Middle Aged</subject><subject>Neuropsychological Tests</subject><subject>Original Paper</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychotic Disorders - complications</subject><subject>Psychotic Disorders - epidemiology</subject><subject>Schizophrenia</subject><subject>Schizophrenia - complications</subject><subject>Schizophrenia - epidemiology</subject><issn>0302-282X</issn><issn>1423-0224</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkstu1DAUhi0EotPCgj1CltjAIuBbbGdTVM1wqVSpSC0Su8hOTmZcEjvYSavyHDwwHs0wAlasbPl8_38uPgg9o-QNpWX1lhDCOaWCPkALKhgvCGPiIVoQTljBNPt6hI5TuiGEikpVj9FRDpeSVGKBfq4CJHzmJ9fCGCEl4yd8HcFMA-Tb-TDGcAt4GdbeTS547Dy-7FuI-DOEsQd856YNvmo27kcYNxG8MzjE_YPpOmgml_Url0Lcqoxvs9kQonUtvpptuvdtDIPp8WqXP-d49wQ96kyf4On-PEFfPry_Xn4qLi4_ni_PLopGlGoqNBMdCMlt04FSnRGVlURapkwpFKFUC6YstEpzDaIllltDjKTCNEpbyjg_Qac733G2A7RN7jiavh6jG0y8r4Nx9d8R7zb1OtzWPNtrXWWDV3uDGL7PkKZ6cKmBvjcewpxqSqiqJCWS_QdKtGa8rGRGX_6D3oQ5-jyJTOWvk6Li2-Jf76gmhpQidIe6Kam3a1Ef1iKzL_5s9ED-3oMMPN8B30xcQzwAe_0v-N-97A</recordid><startdate>201204</startdate><enddate>201204</enddate><creator>Dawes, Sharron E.</creator><creator>Palmer, Barton W.</creator><creator>Meeks, Thomas</creator><creator>Golshan, Shahrokh</creator><creator>Kasckow, John</creator><creator>Mohamed, Somaia</creator><creator>Zisook, Sidney</creator><general>S. 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therapeutic use</topic><topic>citalopram</topic><topic>Citalopram - therapeutic use</topic><topic>Cognition Disorders - drug therapy</topic><topic>Cognition Disorders - etiology</topic><topic>Cognitive ability</topic><topic>Comorbidity</topic><topic>Depression</topic><topic>Depression - complications</topic><topic>Depression - epidemiology</topic><topic>Double-Blind Method</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Mental disorders</topic><topic>Middle Aged</topic><topic>Neuropsychological Tests</topic><topic>Original Paper</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychotic Disorders - complications</topic><topic>Psychotic Disorders - epidemiology</topic><topic>Schizophrenia</topic><topic>Schizophrenia - complications</topic><topic>Schizophrenia - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dawes, Sharron E.</creatorcontrib><creatorcontrib>Palmer, Barton W.</creatorcontrib><creatorcontrib>Meeks, Thomas</creatorcontrib><creatorcontrib>Golshan, Shahrokh</creatorcontrib><creatorcontrib>Kasckow, John</creatorcontrib><creatorcontrib>Mohamed, Somaia</creatorcontrib><creatorcontrib>Zisook, Sidney</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Biology Database (Alumni Edition)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Psychology Database (Alumni)</collection><collection>Science Database (Alumni Edition)</collection><collection>STEM Database</collection><collection>ProQuest Pharma Collection</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest Psychology</collection><collection>Science Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest One Psychology</collection><collection>ProQuest Central Basic</collection><collection>SIRS Editorial</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Neuropsychobiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dawes, Sharron E.</au><au>Palmer, Barton W.</au><au>Meeks, Thomas</au><au>Golshan, Shahrokh</au><au>Kasckow, John</au><au>Mohamed, Somaia</au><au>Zisook, Sidney</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Does Antidepressant Treatment Improve Cognition in Older People with Schizophrenia or Schizoaffective Disorder and Comorbid Subsyndromal Depression?</atitle><jtitle>Neuropsychobiology</jtitle><addtitle>Neuropsychobiology</addtitle><date>2012-04</date><risdate>2012</risdate><volume>65</volume><issue>3</issue><spage>168</spage><epage>172</epage><pages>168-172</pages><issn>0302-282X</issn><eissn>1423-0224</eissn><abstract>Background: Subsyndromal symptoms of depression (SSD) in patients with schizophrenia are common and clinically important. While treatment of depression in major depressive disorder may partially ameliorate cognitive deficits, the cognitive effects of antidepressant medications in patients with schizophrenia or schizoaffective disorder and SSD are unknown. Methods: The goal of this study was to assess the impact of SSD and their treatment on cognition in participants with schizophrenia or schizoaffective disorder aged ≧40 years. Participants were randomly assigned to a flexible dose treatment with citalopram or placebo augmentation of their current medication for 12 weeks. An ANCOVA compared improvement in the cognitive composite scores, and a linear model determined the moderation of cognition on treatment effects based on the Hamilton Depression Rating Scale and the Calgary Depression Rating Scale scores between treatment groups. Results: There were no differences between the citalopram and placebo groups in changes in cognition. Baseline cognitive status did not moderate antidepressant treatment response. Conclusions: Although there are other cogent reasons why SSD in schizophrenia warrant direct intervention, treatment does not substantially affect the level of cognitive functioning. Given the effects of cognitive deficits associated with schizophrenia on functional disability, there remains an ongoing need to identify effective means of directly ameliorating them.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>22456094</pmid><doi>10.1159/000331141</doi><tpages>5</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aging Antidepressants Antidepressive Agents - therapeutic use citalopram Citalopram - therapeutic use Cognition Disorders - drug therapy Cognition Disorders - etiology Cognitive ability Comorbidity Depression Depression - complications Depression - epidemiology Double-Blind Method Female Humans Male Mental disorders Middle Aged Neuropsychological Tests Original Paper Psychiatric Status Rating Scales Psychotic Disorders - complications Psychotic Disorders - epidemiology Schizophrenia Schizophrenia - complications Schizophrenia - epidemiology |
| title | Does Antidepressant Treatment Improve Cognition in Older People with Schizophrenia or Schizoaffective Disorder and Comorbid Subsyndromal Depression? |
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