A new class of powerful inhibitors of monamine oxidase A

It is well established that 1-methyl-4-phenylpyridinium (MPP), the neurotoxic bioactivation product of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and most of its analogs are good competitive inhibitors of monoamine oxidase A, with Ki values in the micromolar range, but they inhibit monoamin...

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Veröffentlicht in:	Biochemical and biophysical research communications 1990-11, Vol.172 (3), p.1338
Hauptverfasser:	Jin, Y Z, Ramsay, R R, Youngster, S K, Singer, T P
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Methyl-4-phenylpyridinium - administration & dosage 1-Methyl-4-phenylpyridinium - analogs & derivatives 1-Methyl-4-phenylpyridinium - pharmacokinetics Binding, Competitive Dose-Response Relationship, Drug Mitochondria - drug effects Monoamine Oxidase Inhibitors - administration & dosage Monoamine Oxidase Inhibitors - pharmacokinetics Placenta - drug effects
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