Fibrinogen residue γAla341 is necessary for calcium binding and ‘A-a’ interactions

The fibrinogen γ-module has several important sites relating to fibrinogen function, which include the high affinity calcium binding site, hole ‘a’ that binds with knob ‘A’, and the D:D interface. Residue γAla341, which is located in the vicinity of these sites, is altered in three variant fibrinoge...

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Veröffentlicht in:	Thrombosis and haemostasis 2012-05, Vol.107 (5), p.875-883
Hauptverfasser:	Park, Rojin, Ping, Lifang, Song, Jaewoo, Hong, Sung-Yu, Choi, Tae-Youn, Choi, Jong-Rak, Gorkun, Oleg V., Lord, Susan T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine Amino Acid Sequence Animals Aspartic Acid Binding Sites Biological and medical sciences Blood Coagulation Blood Coagulation, Fibrinolysis and Cellular Haemostasis Blood coagulation. Blood cells Calcium - metabolism calcium binding CHO Cells Cricetinae Cricetulus dysfibrinogenemia Electrophoresis, Polyacrylamide Gel Factor XIIIa - metabolism Fibrinogen - chemistry Fibrinogen - genetics Fibrinogen - metabolism Fibrinogens, Abnormal - chemistry Fibrinogens, Abnormal - genetics Fibrinogens, Abnormal - metabolism Fibrinolysin - metabolism Fibrinopeptide A - metabolism Fibrinopeptide B - metabolism Fundamental and applied biological sciences. Psychology GPRP binding Hematologic and hematopoietic diseases Humans Kinetics Medical sciences Microscopy, Electron, Scanning Models, Molecular Molecular and cellular biology Molecular Sequence Data Mutation Oligopeptides - metabolism Platelet diseases and coagulopathies Protein Conformation Protein Multimerization Protein Subunits Thrombin - metabolism Transfection Valine γ-module γAla341 ‘A-a’ interaction
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