Prokineticin 2 is an endangering mediator of cerebral ischemic injury

Stroke causes brain dysfunction and neuron death, and the lack of effective therapies heightens the need for new therapeutic targets. Here we identify prokineticin 2 (PK2) as a mediator for cerebral ischemic injury. PK2 is a bioactive peptide initially discovered as a regulator of gastrointestinal m...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-04, Vol.109 (14), p.5475-5480
Hauptverfasser:	Cheng, Michelle Y, Lee, Alex G, Culbertson, Collin, Sun, Guohua, Talati, Rushi K, Manley, Nathan C, Li, Xiaohan, Zhao, Heng, Lyons, David M, Zhou, Qun-Yong, Steinberg, Gary K, Sapolsky, Robert M
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiogenesis Animals antagonists Biological Sciences Brain Brain injury Brain Ischemia Brain Ischemia - physiopathology Calcium Calcium (extracellular) circadian rhythm Circadian rhythms Cortex death Excitotoxicity Gastric motility Gastrointestinal Hormones Gastrointestinal Hormones - genetics Gastrointestinal Hormones - physiology gastrointestinal motility genetics Glutamic acid Glutamic acid receptors (ionotropic) Hypoxia infarction Inflammation Insults Ischemia Messenger RNA mRNA N-Methyl-D-aspartic acid receptors Neostriatum Neurogenesis Neurons Neuropathology Neuropeptides Neuropeptides - genetics Neuropeptides - physiology Pathology physiology physiopathology Rats Reactive oxygen species Receptor mechanisms Receptors Ribonucleic acid RNA RNA interference RNA, Messenger RNA, Messenger - genetics RNA-mediated interference Stroke Strokes Up-Regulation
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