Antiviral Activity and In Vitro Mutation Development Pathways of MK-6186, a Novel Nonnucleoside Reverse Transcriptase Inhibitor

MK-6186 is a novel nonnucleoside reverse transcriptase inhibitor (NNRTI) which displays subnanomolar potency against wild-type (WT) virus and the two most prevalent NNRTI-resistant RT mutants (K103N and Y181C) in biochemical assays. In addition, it showed excellent antiviral potency against K103N an...

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Veröffentlicht in:	Antimicrob. Agents Ch 2012-06, Vol.56 (6), p.3324-3335
Hauptverfasser:	Lu, Meiqing, Felock, Peter J, Munshi, Vandna, Hrin, Renee C, Wang, Ying-Jie, Yan, Youwei, Munshi, Sanjeev, McGaughey, Georgia B, Gomez, Robert, Anthony, Neville J, Williams, Theresa M, Grobler, Jay A, Hazuda, Daria J, McKenna, Philip M, Miller, Michael D, Lai, Ming-Tain
Format:	Artikel
Sprache:	eng
Schlagworte:	antagonists & inhibitors Anti-HIV Agents Anti-HIV Agents - pharmacology Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral activity Antiviral Agents antiviral properties Benzoxazines Benzoxazines - pharmacology Biological and medical sciences Disease resistance drug resistance Efavirenz enzyme inhibitors enzymology genetics HIV Reverse Transcriptase HIV Reverse Transcriptase - antagonists & inhibitors HIV Reverse Transcriptase - genetics HIV-1 HIV-1 - enzymology HIV-1 - genetics Human immunodeficiency virus 1 Medical sciences mutants Mutation non-nucleoside reverse transcriptase inhibitors pharmacology Pharmacology. Drug treatments Reverse Transcriptase Inhibitors Reverse Transcriptase Inhibitors - pharmacology viruses
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