Impact of using linear optimization models in dose planning for HDR brachytherapy

Purpose: Dose plans generated with optimization models hitherto used in high-dose-rate (HDR) brachytherapy have shown a tendency to yield longer dwell times than manually optimized plans. Concern has been raised for the corresponding undesired hot spots, and various methods to mitigate these have be...

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Veröffentlicht in:	Medical physics (Lancaster) 2012-02, Vol.39 (2), p.1021-1028
Hauptverfasser:	Holm, Åsa, Larsson, Torbjörn, Carlsson Tedgren, Åsa
Format:	Artikel
Sprache:	eng
Schlagworte:	BRACHYTHERAPY Brachytherapy - methods cancer COMPARATIVE EVALUATIONS Computer Simulation DOSE RATES Dose‐volume analysis DOSIMETRY Dosimetry/exposure assessment HOT SPOTS Humans Inequalities Linear Models LINEAR PROGRAMMING Male MATEMATIK MATHEMATICS Medical treatment planning Models, Biological NEOPLASMS Numerical modeling optimisation OPTIMIZATION Piecewise linear functions piecewise linear techniques PROSTATE Prostatic Neoplasms - radiotherapy RADIATION DOSES Radiation therapy Radioactive sources RADIOLOGY AND NUCLEAR MEDICINE Radiometry - methods Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted - methods Signal generators Therapeutic applications, including brachytherapy Tissues Treatment planning
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