Tight coevolution of proliferating cell nuclear antigen (PCNA)-partner interaction networks in fungi leads to interspecies network incompatibility

The structure and connectivity of protein-protein interaction (PPI) networks are maintained throughout evolution by coordinated changes (coevolution) of network proteins. Despite extensive research, relatively little is known regarding the molecular basis and functional implications of the coevoluti...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-02, Vol.109 (7), p.E406-E414
Hauptverfasser:	Zamir, Lyad, Zaretsky, Marianna, Fridman, Yearit, Ner-Gaon, Hadas, Rubin, Eitan, Aharoni, Amir
Format:	Artikel
Sprache:	eng
Schlagworte:	Antigens bioinformatics Biological Evolution Biological Sciences cell proliferation Cells coevolution DNA repair DNA replication eukaryotic cells Fungi Fungi - metabolism hybrids Nonnative species PNAS Plus proliferating cell nuclear antigen Proliferating Cell Nuclear Antigen - metabolism protein-protein interactions Proteins Saccharomyces cerevisiae Species Specificity
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