Dickkopf-3, an immune modulator in peripheral CD8 T-cell tolerance

In healthy individuals, T cells react against incoming pathogens, but remain tolerant to self-antigens, thereby preventing autoimmune reactions. CD4 regulatory T cells are major contributors in induction and maintenance of peripheral tolerance, but a regulatory role has been also reported for severa...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2012-01, Vol.109 (5), p.1631-1636
Hauptverfasser:	Papatriantafyllou, Maria, Moldenhauer, Gerhard, Ludwig, Julia, Tafuri, Anna, Garbi, Natalio, Hollmann, Gorana, Küblbeck, Günter, Klevenz, Alexandra, Schmitt, Sabine, Pougialis, Georg, Niehrs, Christof, Gröne, Hermann-Josef, Hämmerling, Gunter J, Arnold, Bernd, Oelert, Thilo
Format:	Artikel
Sprache:	eng
Schlagworte:	adulthood Animal models Animals Antibodies Antigens Autoantigens Autografts Biological Sciences Blotting, Western CD4 antigen CD8 antigen CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - immunology Cell Proliferation Cytotoxicity, Immunologic Exercise tolerance Flow Cytometry Gene expression Immune system Immune tolerance Immune Tolerance - physiology Immunological tolerance Immunomodulation Immunoregulation Intercellular Signaling Peptides and Proteins - physiology Interleukin 2 Lymphocytes T Mice Mice, Inbred C57BL Mice, Transgenic Molecular modelling neoplasms Pathogens Reactivity Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Rodents Skin Splenocytes T cell receptors T lymphocytes Transgenic mice Transplantation tolerance Tumors
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