The HIV-1 Rev response element: An RNA scaffold that directs the cooperative assembly of a homo-oligomeric ribonucleoprotein complex
The HIV-1 Rev response element (RRE) is a ~350 nucleotide, highly structured, cis-acting RNA element essential for viral replication. It is located in the env coding region of the viral genome and is extremely well conserved across different HIV-1 isolates. It is present on all partially spliced and...
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| Veröffentlicht in: | RNA biology 2012-01, Vol.9 (1), p.6-11 |
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| creator | Fernandes, Jason Jayaraman, Bhargavi Frankel, Alan |
| description | The HIV-1 Rev response element (RRE) is a ~350 nucleotide, highly structured, cis-acting RNA element essential for viral replication. It is located in the env coding region of the viral genome and is extremely well conserved across different HIV-1 isolates. It is present on all partially spliced and unspliced viral mRNA transcripts, and serves as an RNA framework onto which multiple molecules of the viral protein Rev assemble. The Rev-RRE oligomeric complex mediates the export of these messages from the nucleus to the cytoplasm, where they are translated to produce essential viral proteins and/or packaged as genomes for new virions. |
| doi_str_mv | 10.4161/rna.9.1.18178 |
| format | Article |
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It is located in the env coding region of the viral genome and is extremely well conserved across different HIV-1 isolates. It is present on all partially spliced and unspliced viral mRNA transcripts, and serves as an RNA framework onto which multiple molecules of the viral protein Rev assemble. The Rev-RRE oligomeric complex mediates the export of these messages from the nucleus to the cytoplasm, where they are translated to produce essential viral proteins and/or packaged as genomes for new virions.</description><subject>assembly</subject><subject>Base Sequence</subject><subject>Binding</subject><subject>Binding Sites</subject><subject>Biology</subject><subject>Bioscience</subject><subject>Calcium</subject><subject>Cancer</subject><subject>Cell</subject><subject>Cycle</subject><subject>Databases, Genetic</subject><subject>export</subject><subject>Gene Expression Regulation, Viral</subject><subject>Genes, rev</subject><subject>HIV</subject><subject>HIV-1 - genetics</subject><subject>HIV-1 - metabolism</subject><subject>HIV-1 - physiology</subject><subject>Landes</subject><subject>Molecular Sequence Data</subject><subject>Multiprotein Complexes - genetics</subject><subject>Multiprotein Complexes - metabolism</subject><subject>Nucleic Acid Conformation</subject><subject>oligomer</subject><subject>Organogenesis</subject><subject>Proteins</subject><subject>Response Elements</subject><subject>Rev</subject><subject>Ribonucleoproteins - genetics</subject><subject>Ribonucleoproteins - metabolism</subject><subject>RNA</subject><subject>RNA Families</subject><subject>RNA, Messenger - genetics</subject><subject>RNA, Messenger - metabolism</subject><subject>RRE</subject><subject>scaffold</subject><subject>Sequence Alignment</subject><subject>virus</subject><subject>Virus Assembly</subject><issn>1547-6286</issn><issn>1555-8584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>0YH</sourceid><sourceid>EIF</sourceid><recordid>eNqFkM9rFDEYhgex2Fo9ei179DJrvvza5CLUonZhsVBaryGTfNNGMpM1mW3Z_97UratCoaeE5Mnzfnmb5h2QOQcJH_Jo53oOc1CwUC-aIxBCtEoo_vJhzxetpEoeNq9L-UEIk0qLV80hpVQo4OKoObm6xdn58nsLs0u8m2Us6zQWnGHEAcfpTXPQ21jw7eN63Fx_-Xx1dt6uLr4uz05XreNcTq1SCwqy877zTDBnhRZggTpOLXpA7nspuXaaK6KE8L63GjXvwDHSSWUdO24-7rzrTTegdzU622jWOQw2b02ywfx_M4Zbc5PuDGOcas6r4P2jIKefGyyTGUJxGKMdMW2KAUK0oFwyXdF2h7qcSsnY72OAmIdOTe3UaAPmd6eVP_l3tj39p8QKqB1QwzyWLqTiAo4O92gV1tOYbrbG5im4iHs3e-YpJQCX304_LS9WBBg1a9__DQxjn_Jg71OO3kx2G1Pusx1dKIY9_ZlfwVSriw</recordid><startdate>20120101</startdate><enddate>20120101</enddate><creator>Fernandes, Jason</creator><creator>Jayaraman, Bhargavi</creator><creator>Frankel, Alan</creator><general>Taylor & Francis</general><general>Landes Bioscience</general><scope>0YH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20120101</creationdate><title>The HIV-1 Rev response element</title><author>Fernandes, Jason ; Jayaraman, Bhargavi ; Frankel, Alan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c446t-887216bddbd353ca5951a12c42aed1e4df6649c9480855ddfa9e94b1c30b68ac3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>assembly</topic><topic>Base Sequence</topic><topic>Binding</topic><topic>Binding Sites</topic><topic>Biology</topic><topic>Bioscience</topic><topic>Calcium</topic><topic>Cancer</topic><topic>Cell</topic><topic>Cycle</topic><topic>Databases, Genetic</topic><topic>export</topic><topic>Gene Expression Regulation, Viral</topic><topic>Genes, rev</topic><topic>HIV</topic><topic>HIV-1 - genetics</topic><topic>HIV-1 - metabolism</topic><topic>HIV-1 - physiology</topic><topic>Landes</topic><topic>Molecular Sequence Data</topic><topic>Multiprotein Complexes - genetics</topic><topic>Multiprotein Complexes - metabolism</topic><topic>Nucleic Acid Conformation</topic><topic>oligomer</topic><topic>Organogenesis</topic><topic>Proteins</topic><topic>Response Elements</topic><topic>Rev</topic><topic>Ribonucleoproteins - genetics</topic><topic>Ribonucleoproteins - metabolism</topic><topic>RNA</topic><topic>RNA Families</topic><topic>RNA, Messenger - genetics</topic><topic>RNA, Messenger - metabolism</topic><topic>RRE</topic><topic>scaffold</topic><topic>Sequence Alignment</topic><topic>virus</topic><topic>Virus Assembly</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fernandes, Jason</creatorcontrib><creatorcontrib>Jayaraman, Bhargavi</creatorcontrib><creatorcontrib>Frankel, Alan</creatorcontrib><collection>Access via Taylor & Francis (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>RNA biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fernandes, Jason</au><au>Jayaraman, Bhargavi</au><au>Frankel, Alan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The HIV-1 Rev response element: An RNA scaffold that directs the cooperative assembly of a homo-oligomeric ribonucleoprotein complex</atitle><jtitle>RNA biology</jtitle><addtitle>RNA Biol</addtitle><date>2012-01-01</date><risdate>2012</risdate><volume>9</volume><issue>1</issue><spage>6</spage><epage>11</epage><pages>6-11</pages><issn>1547-6286</issn><eissn>1555-8584</eissn><abstract>The HIV-1 Rev response element (RRE) is a ~350 nucleotide, highly structured, cis-acting RNA element essential for viral replication. It is located in the env coding region of the viral genome and is extremely well conserved across different HIV-1 isolates. It is present on all partially spliced and unspliced viral mRNA transcripts, and serves as an RNA framework onto which multiple molecules of the viral protein Rev assemble. The Rev-RRE oligomeric complex mediates the export of these messages from the nucleus to the cytoplasm, where they are translated to produce essential viral proteins and/or packaged as genomes for new virions.</abstract><cop>United States</cop><pub>Taylor & Francis</pub><pmid>22258145</pmid><doi>10.4161/rna.9.1.18178</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | RNA biology, 2012-01, Vol.9 (1), p.6-11 |
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| language | eng |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | assembly Base Sequence Binding Binding Sites Biology Bioscience Calcium Cancer Cell Cycle Databases, Genetic export Gene Expression Regulation, Viral Genes, rev HIV HIV-1 - genetics HIV-1 - metabolism HIV-1 - physiology Landes Molecular Sequence Data Multiprotein Complexes - genetics Multiprotein Complexes - metabolism Nucleic Acid Conformation oligomer Organogenesis Proteins Response Elements Rev Ribonucleoproteins - genetics Ribonucleoproteins - metabolism RNA RNA Families RNA, Messenger - genetics RNA, Messenger - metabolism RRE scaffold Sequence Alignment virus Virus Assembly |
| title | The HIV-1 Rev response element: An RNA scaffold that directs the cooperative assembly of a homo-oligomeric ribonucleoprotein complex |
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