Fine-Needle Aspiration Cytology of Metastatic Oligodendroglioma: Case Report and Literature Review
Background: Systemic metastasis of a glial tumor is a rare event. However, metastatic cases are anticipated to increase due to prolongation of survival as a result of the development of new treatment modalities. The possibility of metastasis should be considered in patients with a history of a glial...
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Veröffentlicht in: | Acta cytologica 2012-01, Vol.56 (1), p.97-103 |
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description | Background: Systemic metastasis of a glial tumor is a rare event. However, metastatic cases are anticipated to increase due to prolongation of survival as a result of the development of new treatment modalities. The possibility of metastasis should be considered in patients with a history of a glial tumor rather than a second primary tumor. Fine-needle aspiration cytology is one of the diagnostic procedures primarily applied for confirmation of metastasis in cases with a known primary focus. Therefore, comprehensive knowledge of diagnostic cytomorphologic findings is required in these cases. Case Report: We report a young woman with oligodendroglioma metastasizing to the cervical lymphatic chain 5 years after initial diagnosis. Fine-needle aspiration cytology revealed a highly cellular smear with dispersed single cells and loosely cohesive cell clusters showing rosette-like features on a clean background. The relatively monotonous tumor cells were small sized and had round nuclei with moderate anisonucleosis and scant cytoplasm without extensions. Diagnostic confirmation was made by excisional biopsy and demonstration of 1p19q codeletion on tissue section by fluorescence in situ hybridization. Conclusion: A brief review of the literature with an emphasis on the cytologic features of metastatic oligodendroglioma and differential diagnosis with respect to other metastatic small round cell tumors is provided. |
doi_str_mv | 10.1159/000331769 |
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However, metastatic cases are anticipated to increase due to prolongation of survival as a result of the development of new treatment modalities. The possibility of metastasis should be considered in patients with a history of a glial tumor rather than a second primary tumor. Fine-needle aspiration cytology is one of the diagnostic procedures primarily applied for confirmation of metastasis in cases with a known primary focus. Therefore, comprehensive knowledge of diagnostic cytomorphologic findings is required in these cases. Case Report: We report a young woman with oligodendroglioma metastasizing to the cervical lymphatic chain 5 years after initial diagnosis. Fine-needle aspiration cytology revealed a highly cellular smear with dispersed single cells and loosely cohesive cell clusters showing rosette-like features on a clean background. The relatively monotonous tumor cells were small sized and had round nuclei with moderate anisonucleosis and scant cytoplasm without extensions. Diagnostic confirmation was made by excisional biopsy and demonstration of 1p19q codeletion on tissue section by fluorescence in situ hybridization. Conclusion: A brief review of the literature with an emphasis on the cytologic features of metastatic oligodendroglioma and differential diagnosis with respect to other metastatic small round cell tumors is provided.</description><identifier>ISSN: 0001-5547</identifier><identifier>EISSN: 1938-2650</identifier><identifier>DOI: 10.1159/000331769</identifier><identifier>PMID: 22236753</identifier><language>eng</language><publisher>Basel, Switzerland</publisher><subject>Adult ; Biomarkers, Tumor - analysis ; Biopsy, Fine-Needle ; Brain - pathology ; Brain Neoplasms - genetics ; Brain Neoplasms - pathology ; Brain Neoplasms - surgery ; Chromosome Deletion ; Chromosomes, Human, Pair 1 ; Chromosomes, Human, Pair 19 ; Diagnosis, Differential ; Diagnostic Errors ; Female ; Humans ; In Situ Hybridization, Fluorescence ; Lymph Nodes - pathology ; Magnetic Resonance Imaging ; Neck ; Neuroectodermal Tumors, Primitive - diagnosis ; Novel Insights from Clinical Practice ; Oligodendroglioma - genetics ; Oligodendroglioma - secondary ; Oligodendroglioma - surgery</subject><ispartof>Acta cytologica, 2012-01, Vol.56 (1), p.97-103</ispartof><rights>2012 S. Karger AG, Basel</rights><rights>Copyright © 2012 S. Karger AG, Basel.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c305t-9cb4f5ce16339aa7896af3b71d9bfc650172b048b5c3c7bc38755921cb87e7d83</citedby><cites>FETCH-LOGICAL-c305t-9cb4f5ce16339aa7896af3b71d9bfc650172b048b5c3c7bc38755921cb87e7d83</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,2429,4024,27923,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22236753$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Can, Bilge</creatorcontrib><creatorcontrib>Akpolat, İlkser</creatorcontrib><creatorcontrib>Meydan, Deniz</creatorcontrib><creatorcontrib>Üner, Ayşegül</creatorcontrib><creatorcontrib>Kandemir, Bedri</creatorcontrib><creatorcontrib>Söylemezoğlu, Figen</creatorcontrib><title>Fine-Needle Aspiration Cytology of Metastatic Oligodendroglioma: Case Report and Literature Review</title><title>Acta cytologica</title><addtitle>Acta Cytologica</addtitle><description>Background: Systemic metastasis of a glial tumor is a rare event. However, metastatic cases are anticipated to increase due to prolongation of survival as a result of the development of new treatment modalities. The possibility of metastasis should be considered in patients with a history of a glial tumor rather than a second primary tumor. Fine-needle aspiration cytology is one of the diagnostic procedures primarily applied for confirmation of metastasis in cases with a known primary focus. Therefore, comprehensive knowledge of diagnostic cytomorphologic findings is required in these cases. Case Report: We report a young woman with oligodendroglioma metastasizing to the cervical lymphatic chain 5 years after initial diagnosis. Fine-needle aspiration cytology revealed a highly cellular smear with dispersed single cells and loosely cohesive cell clusters showing rosette-like features on a clean background. The relatively monotonous tumor cells were small sized and had round nuclei with moderate anisonucleosis and scant cytoplasm without extensions. Diagnostic confirmation was made by excisional biopsy and demonstration of 1p19q codeletion on tissue section by fluorescence in situ hybridization. Conclusion: A brief review of the literature with an emphasis on the cytologic features of metastatic oligodendroglioma and differential diagnosis with respect to other metastatic small round cell tumors is provided.</description><subject>Adult</subject><subject>Biomarkers, Tumor - analysis</subject><subject>Biopsy, Fine-Needle</subject><subject>Brain - pathology</subject><subject>Brain Neoplasms - genetics</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain Neoplasms - surgery</subject><subject>Chromosome Deletion</subject><subject>Chromosomes, Human, Pair 1</subject><subject>Chromosomes, Human, Pair 19</subject><subject>Diagnosis, Differential</subject><subject>Diagnostic Errors</subject><subject>Female</subject><subject>Humans</subject><subject>In Situ Hybridization, Fluorescence</subject><subject>Lymph Nodes - pathology</subject><subject>Magnetic Resonance Imaging</subject><subject>Neck</subject><subject>Neuroectodermal Tumors, Primitive - diagnosis</subject><subject>Novel Insights from Clinical Practice</subject><subject>Oligodendroglioma - genetics</subject><subject>Oligodendroglioma - secondary</subject><subject>Oligodendroglioma - surgery</subject><issn>0001-5547</issn><issn>1938-2650</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo90MFLwzAYBfAgis7pwbtIbuKh2jRN03gbxakwHYieS5J-LdG2mUmq7L-3Y3OnwOP3PchD6ILEt4QwcRfHMaWEZ-IATYigeZRkLD5EkzEnEWMpP0Gn3n9uVJbRY3SSJAnNOKMTpOamh-gVoGoBz_zKOBmM7XGxDra1zRrbGr9AkD6MucbL1jS2gr5ytmmN7eQ9LqQH_AYr6wKWfYUXJsBYMrhN-mPg9wwd1bL1cL57p-hj_vBePEWL5eNzMVtEmsYsREKrtGYaSEapkJLnIpM1VZxUQtV6_BDhiYrTXDFNNVea5pwxkRCtcg68yukUXW97V85-D-BD2RmvoW1lD3bwpSAZSVmS81HebKV21nsHdblyppNuXZK43Cxa7hcd7dWudVAdVHv5P-EILrfgS7oG3B7s7v8A1Pt53Q</recordid><startdate>201201</startdate><enddate>201201</enddate><creator>Can, Bilge</creator><creator>Akpolat, İlkser</creator><creator>Meydan, Deniz</creator><creator>Üner, Ayşegül</creator><creator>Kandemir, Bedri</creator><creator>Söylemezoğlu, Figen</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201201</creationdate><title>Fine-Needle Aspiration Cytology of Metastatic Oligodendroglioma: Case Report and Literature Review</title><author>Can, Bilge ; Akpolat, İlkser ; Meydan, Deniz ; Üner, Ayşegül ; Kandemir, Bedri ; Söylemezoğlu, Figen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c305t-9cb4f5ce16339aa7896af3b71d9bfc650172b048b5c3c7bc38755921cb87e7d83</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Adult</topic><topic>Biomarkers, Tumor - analysis</topic><topic>Biopsy, Fine-Needle</topic><topic>Brain - pathology</topic><topic>Brain Neoplasms - genetics</topic><topic>Brain Neoplasms - pathology</topic><topic>Brain Neoplasms - surgery</topic><topic>Chromosome Deletion</topic><topic>Chromosomes, Human, Pair 1</topic><topic>Chromosomes, Human, Pair 19</topic><topic>Diagnosis, Differential</topic><topic>Diagnostic Errors</topic><topic>Female</topic><topic>Humans</topic><topic>In Situ Hybridization, Fluorescence</topic><topic>Lymph Nodes - pathology</topic><topic>Magnetic Resonance Imaging</topic><topic>Neck</topic><topic>Neuroectodermal Tumors, Primitive - diagnosis</topic><topic>Novel Insights from Clinical Practice</topic><topic>Oligodendroglioma - genetics</topic><topic>Oligodendroglioma - secondary</topic><topic>Oligodendroglioma - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Can, Bilge</creatorcontrib><creatorcontrib>Akpolat, İlkser</creatorcontrib><creatorcontrib>Meydan, Deniz</creatorcontrib><creatorcontrib>Üner, Ayşegül</creatorcontrib><creatorcontrib>Kandemir, Bedri</creatorcontrib><creatorcontrib>Söylemezoğlu, Figen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta cytologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Can, Bilge</au><au>Akpolat, İlkser</au><au>Meydan, Deniz</au><au>Üner, Ayşegül</au><au>Kandemir, Bedri</au><au>Söylemezoğlu, Figen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fine-Needle Aspiration Cytology of Metastatic Oligodendroglioma: Case Report and Literature Review</atitle><jtitle>Acta cytologica</jtitle><addtitle>Acta Cytologica</addtitle><date>2012-01</date><risdate>2012</risdate><volume>56</volume><issue>1</issue><spage>97</spage><epage>103</epage><pages>97-103</pages><issn>0001-5547</issn><eissn>1938-2650</eissn><abstract>Background: Systemic metastasis of a glial tumor is a rare event. However, metastatic cases are anticipated to increase due to prolongation of survival as a result of the development of new treatment modalities. The possibility of metastasis should be considered in patients with a history of a glial tumor rather than a second primary tumor. Fine-needle aspiration cytology is one of the diagnostic procedures primarily applied for confirmation of metastasis in cases with a known primary focus. Therefore, comprehensive knowledge of diagnostic cytomorphologic findings is required in these cases. Case Report: We report a young woman with oligodendroglioma metastasizing to the cervical lymphatic chain 5 years after initial diagnosis. Fine-needle aspiration cytology revealed a highly cellular smear with dispersed single cells and loosely cohesive cell clusters showing rosette-like features on a clean background. The relatively monotonous tumor cells were small sized and had round nuclei with moderate anisonucleosis and scant cytoplasm without extensions. Diagnostic confirmation was made by excisional biopsy and demonstration of 1p19q codeletion on tissue section by fluorescence in situ hybridization. Conclusion: A brief review of the literature with an emphasis on the cytologic features of metastatic oligodendroglioma and differential diagnosis with respect to other metastatic small round cell tumors is provided.</abstract><cop>Basel, Switzerland</cop><pmid>22236753</pmid><doi>10.1159/000331769</doi><tpages>7</tpages></addata></record> |
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subjects | Adult Biomarkers, Tumor - analysis Biopsy, Fine-Needle Brain - pathology Brain Neoplasms - genetics Brain Neoplasms - pathology Brain Neoplasms - surgery Chromosome Deletion Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 19 Diagnosis, Differential Diagnostic Errors Female Humans In Situ Hybridization, Fluorescence Lymph Nodes - pathology Magnetic Resonance Imaging Neck Neuroectodermal Tumors, Primitive - diagnosis Novel Insights from Clinical Practice Oligodendroglioma - genetics Oligodendroglioma - secondary Oligodendroglioma - surgery |
title | Fine-Needle Aspiration Cytology of Metastatic Oligodendroglioma: Case Report and Literature Review |
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