Trypanocide, cytotoxic, and antifungal activities of Momordica charantia

Context: Chagas disease, caused by Trypanosoma cruzi, is a public health problem. Currently, chemotherapy is the only available treatment for this disease, and the drugs used, nifurtimox and benzonidazol, present high toxicity levels. An alternative for replacing these drugs are natural extracts fro...

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Veröffentlicht in:	Pharmaceutical biology 2012-02, Vol.50 (2), p.162-166
Hauptverfasser:	Santos, Karla K.A., Matias, Edinardo F.F., Sobral-Souza, Celestina E., Tintino, Saulo R., Morais-Braga, Maria F.B., Guedes, Glaucia M.M., Santos, Francisco A.V., A. Sousa, Ana Carla, Rolón, Miriam, Vega, Celeste, de Arias, Antonieta Rojas, Costa, José G.M., Menezes, Irwin R.A., Coutinho, Henrique D.M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antiepimastigote activity Antifungal Agents - isolation & purification Antifungal Agents - pharmacology Antifungal Agents - toxicity Candida - drug effects Candida spp Cell Line Chagas disease Drug Synergism Inhibitory Concentration 50 Macrophages - drug effects Macrophages - metabolism Medicine, Traditional Metronidazole - administration & dosage Metronidazole - pharmacology Mice Microbial Sensitivity Tests modifying activity Momordica charantia - chemistry Parasitic Sensitivity Tests Plant Extracts - administration & dosage Plant Extracts - pharmacology Plant Extracts - toxicity Plant Leaves Toxicity Tests Trypanocidal Agents - isolation & purification Trypanocidal Agents - pharmacology Trypanocidal Agents - toxicity Trypanosoma cruzi - drug effects
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